Spliceosomal UsnRNP biogenesis, structure and function

Significant advances have been made in elucidating the biogenesis pathway and three-dimensional structure of the UsnRNPs, the building blocks of the spliceosome. U2 and U4/U6•U5 tri-snRNPs functionally associate with the pre-mRNA at an earlier stage of spliceosome assembly than previously thought, a...

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Veröffentlicht in:	Current Opinion in Cell Biology 2001-06, Vol.13 (3), p.290-301
Hauptverfasser:	Will, Cindy L, Lührmann, Reinhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Crystallography Humans Macromolecular Substances pre-mRNA splicing Protein Structure, Tertiary - physiology Protein Transport - physiology Ribonucleoprotein, U1 Small Nuclear - biosynthesis Ribonucleoprotein, U1 Small Nuclear - chemistry Ribonucleoprotein, U1 Small Nuclear - genetics Ribonucleoproteins, Small Nuclear - biosynthesis Ribonucleoproteins, Small Nuclear - chemistry Ribonucleoproteins, Small Nuclear - genetics RNA Splicing - genetics RNA Splicing - physiology RNA, Small Nuclear - chemistry RNA, Small Nuclear - genetics RNA, Small Nuclear - metabolism snRNA snRNA U2 snRNA U4 snRNP snRNP proteins spliceosome Spliceosomes - chemistry Spliceosomes - genetics Spliceosomes - metabolism
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Zusammenfassung:	Significant advances have been made in elucidating the biogenesis pathway and three-dimensional structure of the UsnRNPs, the building blocks of the spliceosome. U2 and U4/U6•U5 tri-snRNPs functionally associate with the pre-mRNA at an earlier stage of spliceosome assembly than previously thought, and additional evidence supporting UsnRNA-mediated catalysis of pre-mRNA splicing has been presented.
ISSN:	0955-0674 1879-0410
DOI:	10.1016/S0955-0674(00)00211-8