Age-related defects in Th1 and Th2 cytokine production by human T cells can be dissociated from altered frequencies of CD45RA + and CD45RO + T cell subsets

The present study investigated whether age-related changes in the production of Th1 and Th2 cytokines by human T cells might be linked to altered frequencies of naive (CD45RA +) and memory (CD45RO +) T cell subsets. T cells from healthy elderly humans ( n=32) stimulated with anti-CD3ε monoclonal ant...

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Veröffentlicht in:	Mechanisms of ageing and development 1999-08, Vol.109 (2), p.97-112
Hauptverfasser:	Karanfilov, Chris I, Liu, Beiqing, Fox, Charity C, Lakshmanan, Romola R, Whisler, Ronald L
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Aging Aging - immunology AIDS/HIV Analysis of the immune response. Humoral and cellular immunity Biological and medical sciences Cells, Cultured Cytokine Female Fundamental and applied biological sciences. Psychology Fundamental immunology Human T cells Humans IFNγ IL-2 IL-4 Immunobiology Interferon-gamma - biosynthesis Interleukin-2 - biosynthesis Interleukin-4 - biosynthesis Leukocyte Common Antigens - immunology Lymphokines, interleukins ( function, expression) Male Regulatory factors and their cellular receptors T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology Th1 and Th2 subsets Th1 Cells - immunology Th2 Cells - immunology
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