The Multidrug Resistance Protein 1: A Functionally Important Activation Marker for Murine Th1 Cells

Previously, we described the expression of an energy-dependent pump in resting murine Th2 (but not resting Th1) cells which extruded the fluorescent dye Fluo-3. After stimulation with Ag and APCs, Th1 cells also expressed this pump. Furthermore, expression of the murine multidrug resistance protein...

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Veröffentlicht in:	The Journal of immunology (1950) 2000-01, Vol.164 (2), p.754-761
Hauptverfasser:	Prechtl, Stefan, Roellinghoff, Martin, Scheper, Rik, Cole, Susan P. C, Deeley, Roger G, Lohoff, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Aniline Compounds - metabolism Animals ATP-Binding Cassette Transporters - antagonists & inhibitors ATP-Binding Cassette Transporters - biosynthesis ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - immunology Biological Transport - genetics Biological Transport - immunology Biomarkers CD4-Positive T-Lymphocytes - chemistry Cell Line Cytokines - biosynthesis DNA, Complementary - genetics Drug Resistance, Multiple - genetics Drug Resistance, Multiple - immunology Female Fluorescent Dyes - metabolism Humans Immunosuppressive Agents - pharmacology Ion Pumps - metabolism Lymphocyte Activation - drug effects Lymphocyte Activation - genetics Mice Mice, Inbred BALB C Mice, Inbred C57BL mrp1 protein Multidrug Resistance-Associated Proteins Propionates - pharmacology Quinolines - pharmacology Staining and Labeling Superantigens - pharmacology Th1 Cells - drug effects Th1 Cells - immunology Th1 Cells - metabolism Transfection Up-Regulation - immunology Xanthenes - metabolism
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