Extracellular adenosine induces apoptosis of human arterial smooth muscle cells via A(2b)-purinoceptor

Apoptosis of arterial smooth muscle cells (ASMCs) could play an important role in the pathogenesis of atherosclerosis and restenosis. Recent studies have demonstrated that extracellular adenosine induces apoptosis in various cell types. Our aim was to delineate the capacity of this nucleoside to ind...

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Veröffentlicht in:	Circulation research 2000-01, Vol.86 (1), p.76-85
Hauptverfasser:	Peyot, M L, Gadeau, A P, Dandré, F, Belloc, I, Dupuch, F, Desgranges, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - physiology Apoptosis - physiology Arteries - cytology Arteries - metabolism Arteries - physiology Cells, Cultured Cyclic AMP - physiology Extracellular Space - metabolism Humans Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - physiology Receptor, Adenosine A2B Receptors, Purinergic P1 - metabolism Receptors, Purinergic P1 - physiology
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