Cell cycle–associated proteins in melanotic neuroectodermal tumor of infancy
Objective. The purpose of the present study was to compare the immunohistochemical expression of cell cycle–associated proteins in neuroblastic and melanocytic cell populations of melanotic neuroectodermal tumor of infancy. Study design. Three cases of melanotic neuroectodermal tumor of infancy were...
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| Veröffentlicht in: | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 1999-10, Vol.88 (4), p.466-468 |
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| container_title | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics |
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| creator | de Souza, Paulo Eduardo Alencar Merly, Flávio Maia, Daniele Maria Fonseca Castro, Wagner Henriques Gomez, Ricardo Santiago |
| description | Objective. The purpose of the present study was to compare the immunohistochemical expression of cell cycle–associated proteins in neuroblastic and melanocytic cell populations of melanotic neuroectodermal tumor of infancy.
Study design. Three cases of melanotic neuroectodermal tumor of infancy were selected. The immunohistochemical expression of MDM-2, p53, proliferating cell nuclear antigen, cyclin D1, and cyclin A was assessed through use of the streptavidin-biotin-peroxidase complex technique.
Results. Positive immunostaining for MDM-2, proliferating cell nuclear antigen, cyclin D1, and cyclin A was occasionally observed in the large melanin-containing epithelioid cells.
Conclusions. These data suggest that MDM-2 expression may be important for the development of melanotic neuroectodermal tumor of infancy and that the melanocytic cell population, not the neuroblastic one, is the proliferative component of the tumor.
(Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;88:466-8) |
| doi_str_mv | 10.1016/S1079-2104(99)70063-6 |
| format | Article |
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Study design. Three cases of melanotic neuroectodermal tumor of infancy were selected. The immunohistochemical expression of MDM-2, p53, proliferating cell nuclear antigen, cyclin D1, and cyclin A was assessed through use of the streptavidin-biotin-peroxidase complex technique.
Results. Positive immunostaining for MDM-2, proliferating cell nuclear antigen, cyclin D1, and cyclin A was occasionally observed in the large melanin-containing epithelioid cells.
Conclusions. These data suggest that MDM-2 expression may be important for the development of melanotic neuroectodermal tumor of infancy and that the melanocytic cell population, not the neuroblastic one, is the proliferative component of the tumor.
(Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;88:466-8)</description><identifier>ISSN: 1079-2104</identifier><identifier>EISSN: 1528-395X</identifier><identifier>DOI: 10.1016/S1079-2104(99)70063-6</identifier><identifier>PMID: 10519756</identifier><language>eng</language><publisher>St. Louis, MO: Mosby, Inc</publisher><subject>Biological and medical sciences ; Cell Cycle Proteins - metabolism ; Dentistry ; Ent. Stomatology ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; Female ; Humans ; Immunohistochemistry ; Infant ; Investigative techniques, diagnostic techniques (general aspects) ; Maxillary Neoplasms - metabolism ; Medical sciences ; Neuroectodermal Tumor, Melanotic - metabolism ; Otorhinolaryngology. Stomatology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Proliferating Cell Nuclear Antigen - metabolism ; Tumors</subject><ispartof>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 1999-10, Vol.88 (4), p.466-468</ispartof><rights>1999 Mosby, Inc.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-d98951661924954ca8455921ac1543e2a675029b5b085364f9da08e2a7e0c8013</citedby><cites>FETCH-LOGICAL-c390t-d98951661924954ca8455921ac1543e2a675029b5b085364f9da08e2a7e0c8013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1079210499700636$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1974405$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10519756$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Souza, Paulo Eduardo Alencar</creatorcontrib><creatorcontrib>Merly, Flávio</creatorcontrib><creatorcontrib>Maia, Daniele Maria Fonseca</creatorcontrib><creatorcontrib>Castro, Wagner Henriques</creatorcontrib><creatorcontrib>Gomez, Ricardo Santiago</creatorcontrib><title>Cell cycle–associated proteins in melanotic neuroectodermal tumor of infancy</title><title>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</title><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><description>Objective. The purpose of the present study was to compare the immunohistochemical expression of cell cycle–associated proteins in neuroblastic and melanocytic cell populations of melanotic neuroectodermal tumor of infancy.
Study design. Three cases of melanotic neuroectodermal tumor of infancy were selected. The immunohistochemical expression of MDM-2, p53, proliferating cell nuclear antigen, cyclin D1, and cyclin A was assessed through use of the streptavidin-biotin-peroxidase complex technique.
Results. Positive immunostaining for MDM-2, proliferating cell nuclear antigen, cyclin D1, and cyclin A was occasionally observed in the large melanin-containing epithelioid cells.
Conclusions. These data suggest that MDM-2 expression may be important for the development of melanotic neuroectodermal tumor of infancy and that the melanocytic cell population, not the neuroblastic one, is the proliferative component of the tumor.
(Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;88:466-8)</description><subject>Biological and medical sciences</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Dentistry</subject><subject>Ent. Stomatology</subject><subject>Facial bones, jaws, teeth, parodontium: diseases, semeiology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Infant</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Maxillary Neoplasms - metabolism</subject><subject>Medical sciences</subject><subject>Neuroectodermal Tumor, Melanotic - metabolism</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Proliferating Cell Nuclear Antigen - metabolism</subject><subject>Tumors</subject><issn>1079-2104</issn><issn>1528-395X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1K7TAQgIMo6lUfQelC5N5FddI2aWclcvAPRBcquAs56RQibaNJe-HsfAff0Ccx50d052qG4Zu_j7F9DsccuDy551BimnEo_iL-KwFknso1ts1FVqU5iqf1mH8hW-xPCM8whxA32RYHwbEUcpvdTqhtEzMzLX28vesQnLF6oDp58W4g24fE9klHre7dYE3S0-gdmcHV5DvdJsPYOZ-4JlKN7s1sl200ug20t4o77PHi_GFyld7cXV5Pzm5SkyMMaY0VCi4lx6xAURhdFUJgxrXhosgp07IUkOFUTKESuSwarDVUsV4SmAp4vsOOlnPjma8jhUF1Npj4iu7JjUGVUOVZWRQRFEvQeBeCp0a9eNtpP1Mc1FykWohUc0sKUS1EKhn7DlYLxmlH9Y-upbkIHK4AHYxuGx_ft-Gbw7gdRMROlxhFG_8teRWMpd5QbX30qGpnf7nkE66tj5U</recordid><startdate>19991001</startdate><enddate>19991001</enddate><creator>de Souza, Paulo Eduardo Alencar</creator><creator>Merly, Flávio</creator><creator>Maia, Daniele Maria Fonseca</creator><creator>Castro, Wagner Henriques</creator><creator>Gomez, Ricardo Santiago</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991001</creationdate><title>Cell cycle–associated proteins in melanotic neuroectodermal tumor of infancy</title><author>de Souza, Paulo Eduardo Alencar ; Merly, Flávio ; Maia, Daniele Maria Fonseca ; Castro, Wagner Henriques ; Gomez, Ricardo Santiago</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-d98951661924954ca8455921ac1543e2a675029b5b085364f9da08e2a7e0c8013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Biological and medical sciences</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>Dentistry</topic><topic>Ent. Stomatology</topic><topic>Facial bones, jaws, teeth, parodontium: diseases, semeiology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Infant</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Maxillary Neoplasms - metabolism</topic><topic>Medical sciences</topic><topic>Neuroectodermal Tumor, Melanotic - metabolism</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Proliferating Cell Nuclear Antigen - metabolism</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Souza, Paulo Eduardo Alencar</creatorcontrib><creatorcontrib>Merly, Flávio</creatorcontrib><creatorcontrib>Maia, Daniele Maria Fonseca</creatorcontrib><creatorcontrib>Castro, Wagner Henriques</creatorcontrib><creatorcontrib>Gomez, Ricardo Santiago</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Souza, Paulo Eduardo Alencar</au><au>Merly, Flávio</au><au>Maia, Daniele Maria Fonseca</au><au>Castro, Wagner Henriques</au><au>Gomez, Ricardo Santiago</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cell cycle–associated proteins in melanotic neuroectodermal tumor of infancy</atitle><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><date>1999-10-01</date><risdate>1999</risdate><volume>88</volume><issue>4</issue><spage>466</spage><epage>468</epage><pages>466-468</pages><issn>1079-2104</issn><eissn>1528-395X</eissn><abstract>Objective. The purpose of the present study was to compare the immunohistochemical expression of cell cycle–associated proteins in neuroblastic and melanocytic cell populations of melanotic neuroectodermal tumor of infancy.
Study design. Three cases of melanotic neuroectodermal tumor of infancy were selected. The immunohistochemical expression of MDM-2, p53, proliferating cell nuclear antigen, cyclin D1, and cyclin A was assessed through use of the streptavidin-biotin-peroxidase complex technique.
Results. Positive immunostaining for MDM-2, proliferating cell nuclear antigen, cyclin D1, and cyclin A was occasionally observed in the large melanin-containing epithelioid cells.
Conclusions. These data suggest that MDM-2 expression may be important for the development of melanotic neuroectodermal tumor of infancy and that the melanocytic cell population, not the neuroblastic one, is the proliferative component of the tumor.
(Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;88:466-8)</abstract><cop>St. Louis, MO</cop><pub>Mosby, Inc</pub><pmid>10519756</pmid><doi>10.1016/S1079-2104(99)70063-6</doi><tpages>3</tpages></addata></record> |
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| subjects | Biological and medical sciences Cell Cycle Proteins - metabolism Dentistry Ent. Stomatology Facial bones, jaws, teeth, parodontium: diseases, semeiology Female Humans Immunohistochemistry Infant Investigative techniques, diagnostic techniques (general aspects) Maxillary Neoplasms - metabolism Medical sciences Neuroectodermal Tumor, Melanotic - metabolism Otorhinolaryngology. Stomatology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Proliferating Cell Nuclear Antigen - metabolism Tumors |
| title | Cell cycle–associated proteins in melanotic neuroectodermal tumor of infancy |
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