Solvent mobility and the protein 'glass' transition

Proteins and other biomolecules undergo a dynamic transition near 200 K to a glass-like solid state with small atomic fluctuations. This dynamic transition can inhibit biological function. To provide a deeper understanding of the relative importance of solvent mobility and the intrinsic protein ener...

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Veröffentlicht in:	Nature Structural Biology 2000, Vol.7 (1), p.34-38
Hauptverfasser:	Vitkup, Dennis, Ringe, Dagmar, Petsko, Gregory A., Karplus, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological Microscopy Biomedical and Life Sciences Computer Simulation Fluctuations Freezing Glass - chemistry Hot Temperature Kinetics letter Life Sciences Low temperature Membrane Biology Myoglobin - chemistry Myoglobin - metabolism Protein Structure Protein Structure, Secondary Solvents Solvents - chemistry Solvents - metabolism Temperature Thermodynamics Viscosity Water - metabolism
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