Non-LTR retrotransposons encoding a restriction enzyme-like endonuclease in vertebrates
All autonomous non-long terminal repeat (non-LTR) retrotransposons reported to date in vertebrates encode an apurinic/apyrimidinic endonuclease-like enzyme necessary for target sequence cleavage and subsequent target-primed reverse transcription. We describe here vertebrate non-LTR retrotransposons...
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| Veröffentlicht in: | Journal of molecular evolution 2001-04, Vol.52 (4), p.351-360 |
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| creator | Volff, J N Körting, C Froschauer, A Sweeney, K Schartl, M |
| description | All autonomous non-long terminal repeat (non-LTR) retrotransposons reported to date in vertebrates encode an apurinic/apyrimidinic endonuclease-like enzyme necessary for target sequence cleavage and subsequent target-primed reverse transcription. We describe here vertebrate non-LTR retrotransposons encoding another type of endonuclease more related to type IIS restriction enzymes. Such retrotransposons have been detected until now only in trypanosomes, nematodes, and arthropods. The retrotransposon Rex6 was identified in the genome of several teleost fish including Xiphophorus maculatus (platyfish), Oryzias latipes (medakafish), Oreochromis niloticus (Nile tilapia), and Fugu rubripes (Japanese pufferfish). Rex6 encodes a reverse transcriptase and a putative restriction enzyme-like endonuclease and is a member of the R4 family of non-LTR retrotransposons containing the Dong and R4 elements found in nematodes and insects. Rex6 was active in many species during teleost evolution and underwent several bursts of retrotransposition (some of them being relatively recent) leading to a high copy number of Rex6 in the genome of numerous fish. Extremely truncated Rex6-related sequences were detected by database screening in reptiles, including the snake Trimeresus flavoviridis and the lizard Anolis carolinensis, but not in sequences from the human genome project, suggesting that this element might have been lost from certain vertebrate lineages. |
| doi_str_mv | 10.1007/s002390010165 |
| format | Article |
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We describe here vertebrate non-LTR retrotransposons encoding another type of endonuclease more related to type IIS restriction enzymes. Such retrotransposons have been detected until now only in trypanosomes, nematodes, and arthropods. The retrotransposon Rex6 was identified in the genome of several teleost fish including Xiphophorus maculatus (platyfish), Oryzias latipes (medakafish), Oreochromis niloticus (Nile tilapia), and Fugu rubripes (Japanese pufferfish). Rex6 encodes a reverse transcriptase and a putative restriction enzyme-like endonuclease and is a member of the R4 family of non-LTR retrotransposons containing the Dong and R4 elements found in nematodes and insects. Rex6 was active in many species during teleost evolution and underwent several bursts of retrotransposition (some of them being relatively recent) leading to a high copy number of Rex6 in the genome of numerous fish. Extremely truncated Rex6-related sequences were detected by database screening in reptiles, including the snake Trimeresus flavoviridis and the lizard Anolis carolinensis, but not in sequences from the human genome project, suggesting that this element might have been lost from certain vertebrate lineages.</description><identifier>ISSN: 0022-2844</identifier><identifier>EISSN: 1432-1432</identifier><identifier>DOI: 10.1007/s002390010165</identifier><identifier>PMID: 11343131</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Amino Acid Sequence ; Animals ; Base Sequence ; deoxyribonuclease ; Enzymes ; Evolution, Molecular ; Evolutionary biology ; Fish ; Fishes - classification ; Fishes - genetics ; Fugu rubripes ; Genomics ; Molecular biology ; Oreochromis niloticus ; Oryzias latipes ; Phylogeny ; Polymerase Chain Reaction ; Reptiles ; Reptiles - genetics ; Retroelements ; Sequence Alignment ; Sequence Homology, Nucleic Acid ; Terminal Repeat Sequences ; transposon Rex6 ; Vertebrates ; Xiphophorus maculatus</subject><ispartof>Journal of molecular evolution, 2001-04, Vol.52 (4), p.351-360</ispartof><rights>Springer-Verlag New York Inc. 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-5330d90b7daf7b15cc8009ea4c5cb957a728531b2ab418d7da2d54a64be02b6c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11343131$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Volff, J N</creatorcontrib><creatorcontrib>Körting, C</creatorcontrib><creatorcontrib>Froschauer, A</creatorcontrib><creatorcontrib>Sweeney, K</creatorcontrib><creatorcontrib>Schartl, M</creatorcontrib><title>Non-LTR retrotransposons encoding a restriction enzyme-like endonuclease in vertebrates</title><title>Journal of molecular evolution</title><addtitle>J Mol Evol</addtitle><description>All autonomous non-long terminal repeat (non-LTR) retrotransposons reported to date in vertebrates encode an apurinic/apyrimidinic endonuclease-like enzyme necessary for target sequence cleavage and subsequent target-primed reverse transcription. We describe here vertebrate non-LTR retrotransposons encoding another type of endonuclease more related to type IIS restriction enzymes. Such retrotransposons have been detected until now only in trypanosomes, nematodes, and arthropods. The retrotransposon Rex6 was identified in the genome of several teleost fish including Xiphophorus maculatus (platyfish), Oryzias latipes (medakafish), Oreochromis niloticus (Nile tilapia), and Fugu rubripes (Japanese pufferfish). Rex6 encodes a reverse transcriptase and a putative restriction enzyme-like endonuclease and is a member of the R4 family of non-LTR retrotransposons containing the Dong and R4 elements found in nematodes and insects. Rex6 was active in many species during teleost evolution and underwent several bursts of retrotransposition (some of them being relatively recent) leading to a high copy number of Rex6 in the genome of numerous fish. Extremely truncated Rex6-related sequences were detected by database screening in reptiles, including the snake Trimeresus flavoviridis and the lizard Anolis carolinensis, but not in sequences from the human genome project, suggesting that this element might have been lost from certain vertebrate lineages.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>deoxyribonuclease</subject><subject>Enzymes</subject><subject>Evolution, Molecular</subject><subject>Evolutionary biology</subject><subject>Fish</subject><subject>Fishes - classification</subject><subject>Fishes - genetics</subject><subject>Fugu rubripes</subject><subject>Genomics</subject><subject>Molecular biology</subject><subject>Oreochromis niloticus</subject><subject>Oryzias latipes</subject><subject>Phylogeny</subject><subject>Polymerase Chain Reaction</subject><subject>Reptiles</subject><subject>Reptiles - genetics</subject><subject>Retroelements</subject><subject>Sequence Alignment</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Terminal Repeat Sequences</subject><subject>transposon Rex6</subject><subject>Vertebrates</subject><subject>Xiphophorus maculatus</subject><issn>0022-2844</issn><issn>1432-1432</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0c9LwzAUB_AgipvTo1cpHrxVX3416VGGv2AoyMRjSdJMOttkJq0w_3ozNhC9eMkL7314JHwROsVwiQHEVQQgtATAgAu-h8aYUZJvjn00TiOSE8nYCB3FuExI8JIeohHGlFFM8Ri9PnqXz-bPWbB98H1QLq589C5m1hlfN-4tU2kW-9CYvvEutb_Wnc3b5t2me-3dYFqros0al33a0FsdVG_jMTpYqDbak12doJfbm_n0Pp893T1Mr2e5YZj2OacU6hK0qNVCaMyNkQClVcxwo0sulCCSU6yJ0gzLOjFSc6YKpi0QXRg6QRfbvavgP4b0zqprorFtq5z1Q6wESApMFP9CLEFQWtAEz__ApR-CS5-oSiIFk4yIhPItMsHHGOyiWoWmU2FdYag2uVS_ckn-bLd00J2tf_QuCPoNSO6IDQ</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>Volff, J N</creator><creator>Körting, C</creator><creator>Froschauer, A</creator><creator>Sweeney, K</creator><creator>Schartl, M</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>20010401</creationdate><title>Non-LTR retrotransposons encoding a restriction enzyme-like endonuclease in vertebrates</title><author>Volff, J N ; Körting, C ; Froschauer, A ; Sweeney, K ; Schartl, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-5330d90b7daf7b15cc8009ea4c5cb957a728531b2ab418d7da2d54a64be02b6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>deoxyribonuclease</topic><topic>Enzymes</topic><topic>Evolution, Molecular</topic><topic>Evolutionary biology</topic><topic>Fish</topic><topic>Fishes - classification</topic><topic>Fishes - genetics</topic><topic>Fugu rubripes</topic><topic>Genomics</topic><topic>Molecular biology</topic><topic>Oreochromis niloticus</topic><topic>Oryzias latipes</topic><topic>Phylogeny</topic><topic>Polymerase Chain Reaction</topic><topic>Reptiles</topic><topic>Reptiles - genetics</topic><topic>Retroelements</topic><topic>Sequence Alignment</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Terminal Repeat Sequences</topic><topic>transposon Rex6</topic><topic>Vertebrates</topic><topic>Xiphophorus maculatus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Volff, J N</creatorcontrib><creatorcontrib>Körting, C</creatorcontrib><creatorcontrib>Froschauer, A</creatorcontrib><creatorcontrib>Sweeney, K</creatorcontrib><creatorcontrib>Schartl, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of molecular evolution</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Volff, J N</au><au>Körting, C</au><au>Froschauer, A</au><au>Sweeney, K</au><au>Schartl, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-LTR retrotransposons encoding a restriction enzyme-like endonuclease in vertebrates</atitle><jtitle>Journal of molecular evolution</jtitle><addtitle>J Mol Evol</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>52</volume><issue>4</issue><spage>351</spage><epage>360</epage><pages>351-360</pages><issn>0022-2844</issn><eissn>1432-1432</eissn><abstract>All autonomous non-long terminal repeat (non-LTR) retrotransposons reported to date in vertebrates encode an apurinic/apyrimidinic endonuclease-like enzyme necessary for target sequence cleavage and subsequent target-primed reverse transcription. We describe here vertebrate non-LTR retrotransposons encoding another type of endonuclease more related to type IIS restriction enzymes. Such retrotransposons have been detected until now only in trypanosomes, nematodes, and arthropods. The retrotransposon Rex6 was identified in the genome of several teleost fish including Xiphophorus maculatus (platyfish), Oryzias latipes (medakafish), Oreochromis niloticus (Nile tilapia), and Fugu rubripes (Japanese pufferfish). Rex6 encodes a reverse transcriptase and a putative restriction enzyme-like endonuclease and is a member of the R4 family of non-LTR retrotransposons containing the Dong and R4 elements found in nematodes and insects. Rex6 was active in many species during teleost evolution and underwent several bursts of retrotransposition (some of them being relatively recent) leading to a high copy number of Rex6 in the genome of numerous fish. Extremely truncated Rex6-related sequences were detected by database screening in reptiles, including the snake Trimeresus flavoviridis and the lizard Anolis carolinensis, but not in sequences from the human genome project, suggesting that this element might have been lost from certain vertebrate lineages.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>11343131</pmid><doi>10.1007/s002390010165</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0022-2844 |
| ispartof | Journal of molecular evolution, 2001-04, Vol.52 (4), p.351-360 |
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| language | eng |
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| subjects | Amino Acid Sequence Animals Base Sequence deoxyribonuclease Enzymes Evolution, Molecular Evolutionary biology Fish Fishes - classification Fishes - genetics Fugu rubripes Genomics Molecular biology Oreochromis niloticus Oryzias latipes Phylogeny Polymerase Chain Reaction Reptiles Reptiles - genetics Retroelements Sequence Alignment Sequence Homology, Nucleic Acid Terminal Repeat Sequences transposon Rex6 Vertebrates Xiphophorus maculatus |
| title | Non-LTR retrotransposons encoding a restriction enzyme-like endonuclease in vertebrates |
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