The Effects of Nucleus Basalis Magnocellularis Lesions in Long-Evans Hooded Rats on Two Learning Set Formation Tasks, Delayed Matching-to-Sample Learning, and Open-Field Activity
Rats with quisqualic acid lesions of the nucleus basalis magnocellularis (nBM) and control rats were compared in discrimination reversal learning set (DRLS) and olfactory discrimination learning set (ODLS) tasks, a delayed matching-to-sample task (DMTS), and open-field activity. Evidence of learning...
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| Veröffentlicht in: | Behavioral neuroscience 2001-04, Vol.115 (2), p.328-340 |
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| creator | Bailey, Aileen M Thomas, Roger K |
| description | Rats with quisqualic acid lesions of the nucleus basalis magnocellularis (nBM) and control rats were compared in discrimination reversal learning set (DRLS) and olfactory discrimination learning set (ODLS) tasks, a delayed matching-to-sample task (DMTS), and open-field activity. Evidence of learning set formation was seen in control rats but not in nBM-lesioned rats in both the DRLS and ODLS tasks. Better-than-chance performances were seen for both groups in DMTS, indicating no impairment after nBM lesions. There were no group differences in open-field activity. These findings suggest that the nBM is important for higher cognitive processing such as "learning to learn" and thus is important for a complex form of reference memory. In addition, perseverational, working memory, and attentional deficits could not explain learning set impairment after nBM lesions. |
| doi_str_mv | 10.1037/0735-7044.115.2.328 |
| format | Article |
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Evidence of learning set formation was seen in control rats but not in nBM-lesioned rats in both the DRLS and ODLS tasks. Better-than-chance performances were seen for both groups in DMTS, indicating no impairment after nBM lesions. There were no group differences in open-field activity. These findings suggest that the nBM is important for higher cognitive processing such as "learning to learn" and thus is important for a complex form of reference memory. 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Psychology ; Learning ; Lesions ; Male ; Matching to Sample ; Memory ; Mental Recall - physiology ; Motor Activity - physiology ; Neurology ; Odor Discrimination ; Problem Solving - physiology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Long-Evans ; Retention (Psychology) - physiology ; Reversal Learning - physiology ; Reversal Shift Learning ; Rodents ; Smell - physiology</subject><ispartof>Behavioral neuroscience, 2001-04, Vol.115 (2), p.328-340</ispartof><rights>2001 American Psychological Association</rights><rights>2001 INIST-CNRS</rights><rights>Copyright American Psychological Association Apr 2001</rights><rights>2001, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a414t-85693bebb97fa0b1907d5e20f9acc1bc3b6e327dbf49a1dfa21d3f234a1718353</citedby><cites>FETCH-LOGICAL-a414t-85693bebb97fa0b1907d5e20f9acc1bc3b6e327dbf49a1dfa21d3f234a1718353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1096099$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11345958$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bailey, Aileen M</creatorcontrib><creatorcontrib>Thomas, Roger K</creatorcontrib><title>The Effects of Nucleus Basalis Magnocellularis Lesions in Long-Evans Hooded Rats on Two Learning Set Formation Tasks, Delayed Matching-to-Sample Learning, and Open-Field Activity</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>Rats with quisqualic acid lesions of the nucleus basalis magnocellularis (nBM) and control rats were compared in discrimination reversal learning set (DRLS) and olfactory discrimination learning set (ODLS) tasks, a delayed matching-to-sample task (DMTS), and open-field activity. Evidence of learning set formation was seen in control rats but not in nBM-lesioned rats in both the DRLS and ODLS tasks. Better-than-chance performances were seen for both groups in DMTS, indicating no impairment after nBM lesions. There were no group differences in open-field activity. These findings suggest that the nBM is important for higher cognitive processing such as "learning to learn" and thus is important for a complex form of reference memory. In addition, perseverational, working memory, and attentional deficits could not explain learning set impairment after nBM lesions.</description><subject>Anatomical correlates of behavior</subject><subject>Animal</subject><subject>Animal behavior</subject><subject>Animal Open Field Behavior</subject><subject>Animals</subject><subject>Attention - physiology</subject><subject>Basal Nucleus of Meynert - physiology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain Mapping</subject><subject>Discrimination Learning</subject><subject>Discrimination Learning - physiology</subject><subject>Forebrain</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Learning</subject><subject>Lesions</subject><subject>Male</subject><subject>Matching to Sample</subject><subject>Memory</subject><subject>Mental Recall - physiology</subject><subject>Motor Activity - physiology</subject><subject>Neurology</subject><subject>Odor Discrimination</subject><subject>Problem Solving - physiology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>Retention (Psychology) - physiology</subject><subject>Reversal Learning - physiology</subject><subject>Reversal Shift Learning</subject><subject>Rodents</subject><subject>Smell - physiology</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kt1uFCEYhomxsWv1CkwMMepRZ4WB-eGw1l1rsrWJXY_JNwxsqbMwhZmavS2vUCa7aRsPPCJfeN4XwgNCbyiZU8KqT6RiRVYRzueUFvN8zvL6GZpRwURGSM2fo9kDcYxexnhLCOGEFy_QMaWMF6KoZ-jP-kbjhTFaDRF7g7-PqtNjxJ8hQmcjvoSN80p33dhBSPNKR-tdxNbhlXebbHEPabrwvtUt_gFTicPr3z6BEJx1G3ytB7z0YQuDnbYg_oqn-IvuYJcSlzCom0Rlg8-uYdt3-iF4isG1-KrXLlta3bX4TA323g67V-jIQBf168N6gn4uF-vzi2x19fXb-dkqA075kNVFKVijm0ZUBkhDBanaQufECFCKNoo1pWZ51TaGC6CtgZy2zOSMA61ozQp2gj7ue_vg70YdB7m1cXoKcNqPUVakzkXB8wS--we89WNw6W6ypJwVhLPyf1BOmKBU8CpBbA-p4GMM2sg-2C2EnaRETtLlpFROSmWSLnOZpKfU20P12Gx1-5g5WE7A-wMAUUFnAjhl45NuURIhEvZhj0EPso87BWGw6TtE2Tj95Ly_pWjBRQ</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>Bailey, Aileen M</creator><creator>Thomas, Roger K</creator><general>American Psychological Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope></search><sort><creationdate>20010401</creationdate><title>The Effects of Nucleus Basalis Magnocellularis Lesions in Long-Evans Hooded Rats on Two Learning Set Formation Tasks, Delayed Matching-to-Sample Learning, and Open-Field Activity</title><author>Bailey, Aileen M ; Thomas, Roger K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a414t-85693bebb97fa0b1907d5e20f9acc1bc3b6e327dbf49a1dfa21d3f234a1718353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Anatomical correlates of behavior</topic><topic>Animal</topic><topic>Animal behavior</topic><topic>Animal Open Field Behavior</topic><topic>Animals</topic><topic>Attention - physiology</topic><topic>Basal Nucleus of Meynert - physiology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain Mapping</topic><topic>Discrimination Learning</topic><topic>Discrimination Learning - physiology</topic><topic>Forebrain</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Learning</topic><topic>Lesions</topic><topic>Male</topic><topic>Matching to Sample</topic><topic>Memory</topic><topic>Mental Recall - physiology</topic><topic>Motor Activity - physiology</topic><topic>Neurology</topic><topic>Odor Discrimination</topic><topic>Problem Solving - physiology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><topic>Retention (Psychology) - physiology</topic><topic>Reversal Learning - physiology</topic><topic>Reversal Shift Learning</topic><topic>Rodents</topic><topic>Smell - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bailey, Aileen M</creatorcontrib><creatorcontrib>Thomas, Roger K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Access via APA PsycArticles® (ProQuest)</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bailey, Aileen M</au><au>Thomas, Roger K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects of Nucleus Basalis Magnocellularis Lesions in Long-Evans Hooded Rats on Two Learning Set Formation Tasks, Delayed Matching-to-Sample Learning, and Open-Field Activity</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>115</volume><issue>2</issue><spage>328</spage><epage>340</epage><pages>328-340</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><coden>BENEDJ</coden><abstract>Rats with quisqualic acid lesions of the nucleus basalis magnocellularis (nBM) and control rats were compared in discrimination reversal learning set (DRLS) and olfactory discrimination learning set (ODLS) tasks, a delayed matching-to-sample task (DMTS), and open-field activity. Evidence of learning set formation was seen in control rats but not in nBM-lesioned rats in both the DRLS and ODLS tasks. Better-than-chance performances were seen for both groups in DMTS, indicating no impairment after nBM lesions. There were no group differences in open-field activity. These findings suggest that the nBM is important for higher cognitive processing such as "learning to learn" and thus is important for a complex form of reference memory. In addition, perseverational, working memory, and attentional deficits could not explain learning set impairment after nBM lesions.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>11345958</pmid><doi>10.1037/0735-7044.115.2.328</doi><tpages>13</tpages></addata></record> |
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| subjects | Anatomical correlates of behavior Animal Animal behavior Animal Open Field Behavior Animals Attention - physiology Basal Nucleus of Meynert - physiology Behavioral psychophysiology Biological and medical sciences Brain Brain Mapping Discrimination Learning Discrimination Learning - physiology Forebrain Fundamental and applied biological sciences. Psychology Learning Lesions Male Matching to Sample Memory Mental Recall - physiology Motor Activity - physiology Neurology Odor Discrimination Problem Solving - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Long-Evans Retention (Psychology) - physiology Reversal Learning - physiology Reversal Shift Learning Rodents Smell - physiology |
| title | The Effects of Nucleus Basalis Magnocellularis Lesions in Long-Evans Hooded Rats on Two Learning Set Formation Tasks, Delayed Matching-to-Sample Learning, and Open-Field Activity |
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