Regulation of antigen-induced human T-lymphocyte responses by calcineurin antagonists

Background: Cyclosporin A (CS) and tacrolimus (FK506, FK) are calcineurin antagonists used widely as T-cell immunosuppressants; however, their relative efficacy on antigen-stimulated T-cell subsets remains undefined. Objective: We have examined the effects of CS and FK on antigen-driven proliferatio...

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Veröffentlicht in:	Journal of allergy and clinical immunology 1999-10, Vol.104 (4), p.828-835
Hauptverfasser:	Pacocha, Sarah E., Oriente, Alfonso, Huang, Shau-Ku, Essayan, David M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences calcineurin antagonists Calcineurin Inhibitors cyclosporin A cyclosporine Cyclosporine - pharmacology Dose-Response Relationship, Drug FK506 Gene Expression Regulation - drug effects Human Humans Hypersensitivity - immunology IFN-γ IL-13 IL-4 IL-5 Immunomodulators Interferon-gamma - metabolism Interleukins - metabolism Lymphocyte Activation - drug effects Medical sciences Pharmacology. Drug treatments Signal Transduction - drug effects T lymphocyte T-Lymphocytes, Helper-Inducer - drug effects tacrolimus Tacrolimus - pharmacology
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