Serum Amyloid A Protein (SAA) in Colorectal Carcinoma
The changes in serum levels of serum amyloid A protein were studied in 67 patients suffering from colorectal carcinoma and compared to three other major acute phase proteins: C-reactive protein, α1-antichymotrypsin and α1-acid glycoprotein. Although the presence of colorectal carcinoma caused an inc...
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| Veröffentlicht in: | Clinical chemistry and laboratory medicine 2001-02, Vol.39 (2), p.129-133 |
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| creator | GLOJNARIC, Ines CASL, Martin-Tino SIMIC, Diana LUKAC, Josip |
| description | The changes in serum levels of serum amyloid A protein were studied in 67 patients suffering from colorectal carcinoma and compared to three other major acute phase proteins: C-reactive protein, α1-antichymotrypsin and α1-acid glycoprotein. Although the presence of colorectal carcinoma caused an increase in serum levels of all the acute phase reactants studied, serum amyloid A protein showed the most powerful reaction in pre-operative disease stage, with the mean value of 330 mg/l (range 7–2506 mg/l) as compared to the normal values of |
| doi_str_mv | 10.1515/CCLM.2001.022 |
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Although the presence of colorectal carcinoma caused an increase in serum levels of all the acute phase reactants studied, serum amyloid A protein showed the most powerful reaction in pre-operative disease stage, with the mean value of 330 mg/l (range 7–2506 mg/l) as compared to the normal values of <1.2 mg/l obtained in 30 healthy adults. The mean serum amyloid A protein concentration increased to 487 mg/l after surgery, declining during the post-operative clinical course until the sixth chemotherapy cycle (from 167mg/l to 64 mg/l), but never returned to the normal range. In the later chemotherapy cycles, mean serum amyloid A protein increased to 163 mg/l, probably as a result of the disease relapse. According to the statistical relations among exact confidence intervals for proportions, serum amyloid A protein showed the best specificity for colorectal carcinoma of all the acute phase proteins studied (83–100%) and also a sensitivity of 100%. We concluded that serum amyloid A protein seems to be a reliable parameter, which could be recommended for clinical routine as a non-specific tumour marker for colorectal carcinoma.</description><identifier>ISSN: 1434-6621</identifier><identifier>EISSN: 1437-4331</identifier><identifier>DOI: 10.1515/CCLM.2001.022</identifier><identifier>PMID: 11341746</identifier><language>eng</language><publisher>Berlin: Walter de Gruyter</publisher><subject>alpha 1-Antichymotrypsin - blood ; Biological and medical sciences ; Biomarkers, Tumor - blood ; C-Reactive Protein - metabolism ; Case-Control Studies ; Colorectal Neoplasms - blood ; Colorectal Neoplasms - drug therapy ; Colorectal Neoplasms - surgery ; Confidence Intervals ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Medical sciences ; Orosomucoid - metabolism ; Serum Amyloid A Protein - metabolism ; Stomach. Duodenum. Small intestine. Colon. Rectum. 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Although the presence of colorectal carcinoma caused an increase in serum levels of all the acute phase reactants studied, serum amyloid A protein showed the most powerful reaction in pre-operative disease stage, with the mean value of 330 mg/l (range 7–2506 mg/l) as compared to the normal values of <1.2 mg/l obtained in 30 healthy adults. The mean serum amyloid A protein concentration increased to 487 mg/l after surgery, declining during the post-operative clinical course until the sixth chemotherapy cycle (from 167mg/l to 64 mg/l), but never returned to the normal range. In the later chemotherapy cycles, mean serum amyloid A protein increased to 163 mg/l, probably as a result of the disease relapse. According to the statistical relations among exact confidence intervals for proportions, serum amyloid A protein showed the best specificity for colorectal carcinoma of all the acute phase proteins studied (83–100%) and also a sensitivity of 100%. We concluded that serum amyloid A protein seems to be a reliable parameter, which could be recommended for clinical routine as a non-specific tumour marker for colorectal carcinoma.</description><subject>alpha 1-Antichymotrypsin - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - blood</subject><subject>C-Reactive Protein - metabolism</subject><subject>Case-Control Studies</subject><subject>Colorectal Neoplasms - blood</subject><subject>Colorectal Neoplasms - drug therapy</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Confidence Intervals</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Orosomucoid - metabolism</subject><subject>Serum Amyloid A Protein - metabolism</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Orosomucoid - metabolism</topic><topic>Serum Amyloid A Protein - metabolism</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GLOJNARIC, Ines</creatorcontrib><creatorcontrib>CASL, Martin-Tino</creatorcontrib><creatorcontrib>SIMIC, Diana</creatorcontrib><creatorcontrib>LUKAC, Josip</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical chemistry and laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GLOJNARIC, Ines</au><au>CASL, Martin-Tino</au><au>SIMIC, Diana</au><au>LUKAC, Josip</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Amyloid A Protein (SAA) in Colorectal Carcinoma</atitle><jtitle>Clinical chemistry and laboratory medicine</jtitle><addtitle>Clinical Chemistry and Laboratory Medicine</addtitle><date>2001-02-01</date><risdate>2001</risdate><volume>39</volume><issue>2</issue><spage>129</spage><epage>133</epage><pages>129-133</pages><issn>1434-6621</issn><eissn>1437-4331</eissn><abstract>The changes in serum levels of serum amyloid A protein were studied in 67 patients suffering from colorectal carcinoma and compared to three other major acute phase proteins: C-reactive protein, α1-antichymotrypsin and α1-acid glycoprotein. Although the presence of colorectal carcinoma caused an increase in serum levels of all the acute phase reactants studied, serum amyloid A protein showed the most powerful reaction in pre-operative disease stage, with the mean value of 330 mg/l (range 7–2506 mg/l) as compared to the normal values of <1.2 mg/l obtained in 30 healthy adults. The mean serum amyloid A protein concentration increased to 487 mg/l after surgery, declining during the post-operative clinical course until the sixth chemotherapy cycle (from 167mg/l to 64 mg/l), but never returned to the normal range. In the later chemotherapy cycles, mean serum amyloid A protein increased to 163 mg/l, probably as a result of the disease relapse. According to the statistical relations among exact confidence intervals for proportions, serum amyloid A protein showed the best specificity for colorectal carcinoma of all the acute phase proteins studied (83–100%) and also a sensitivity of 100%. 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| source | MEDLINE; De Gruyter journals |
| subjects | alpha 1-Antichymotrypsin - blood Biological and medical sciences Biomarkers, Tumor - blood C-Reactive Protein - metabolism Case-Control Studies Colorectal Neoplasms - blood Colorectal Neoplasms - drug therapy Colorectal Neoplasms - surgery Confidence Intervals Gastroenterology. Liver. Pancreas. Abdomen Humans Medical sciences Orosomucoid - metabolism Serum Amyloid A Protein - metabolism Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Serum Amyloid A Protein (SAA) in Colorectal Carcinoma |
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