EphA Receptors Regulate Growth Cone Dynamics through the Novel Guanine Nucleotide Exchange Factor Ephexin

Eph receptors transduce short-range repulsive signals for axon guidance by modulating actin dynamics within growth cones. We report the cloning and characterization of ephexin, a novel Eph receptor-interacting protein that is a member of the Dbl family of guanine nucleotide exchange factors (GEFs) f...

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Veröffentlicht in:	Cell 2001-04, Vol.105 (2), p.233-244
Hauptverfasser:	Shamah, Steven M., Lin, Michael Z., Goldberg, Jeffrey L., Estrach, Soline, Sahin, Mustafa, Hu, Linda, Bazalakova, Mihaela, Neve, Rachel L., Corfas, Gabriel, Debant, Anne, Greenberg, Michael E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Amino Acid Sequence Animals Brain Chemistry Cells, Cultured Cloning, Molecular Embryo, Mammalian - physiology Eph receptor-interacting protein ephexin Ephrin-A1 Eye - cytology Fetal Proteins - metabolism Growth Cones - drug effects Growth Cones - metabolism guanine nucleotide exchange factor Guanine Nucleotide Exchange Factors - chemistry Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - metabolism Immunoblotting In Situ Hybridization Mice Molecular Sequence Data Nerve Tissue Proteins - metabolism Phylogeny Protein Structure, Tertiary Proteins - pharmacology Rats Receptor Protein-Tyrosine Kinases - metabolism rho GTP-Binding Proteins - metabolism Signal Transduction - physiology Two-Hybrid System Techniques
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