Effect of zinc supplementation on trace elements and intestinal metallothionein concentrations in experimental colitis in the rat
Background and Aim. Zinc enhances cell protection against infection and injury and the healing processes themselves. We evaluated the effect of zinc supplementation at different doses on a model of experimental colitis in the rat. Methods. Colitis, induced by intro-rectal instillation of dinitrobenz...
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| Veröffentlicht in: | Digestive and liver disease 2001-03, Vol.33 (2), p.135-139 |
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| creator | Di Leo, V. D'Incà, R. Barollo, M. Tropea, A. Fries, W. Mazzon, E. Irato, P. Cecchetto, A. Sturniolo, G.C. |
| description | Background and Aim. Zinc enhances cell protection against infection and injury and the healing processes themselves. We evaluated the effect of zinc supplementation at different doses on a model of experimental colitis in the rat.
Methods. Colitis, induced by intro-rectal instillation of dinitrobenzen-sulphonic acid, was assessed at 1 week by examining: general outcome and macroscopic damage, myeloperoxidase activity, mucosal zinc, iron and metallothionein concentrations. Rats received zinc sulphate, 2 mg/kg or 30 mg/kg, twice a day by gavage for 9 days, starting 3 days before the induction of colitis, or intrarectal instillation of zinc (20 mg/kg) once daily starting S hours after the induction of colitis and for 6 days thereafter.
Results. Zinc-treated rats had less diarrhoea, higher body weight and lower colonic weight than untreated rats but no effect was observed on macroscopic inflammation, adhesions, colonic distension and neutrophil infiltration of the colonic mucosa. Zinc supplementation did not affect mucosal iron and zinc concentrations or plasma zinc levels in colitic rats. Metallothionein synthesis was induced in control rats and to a lesser extent in colitic rats.
Conclusion. Zinc administration induces metallothionein synthesis but has little effect on the short-term course of experimental colitis. |
| doi_str_mv | 10.1016/S1590-8658(01)80068-2 |
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Methods. Colitis, induced by intro-rectal instillation of dinitrobenzen-sulphonic acid, was assessed at 1 week by examining: general outcome and macroscopic damage, myeloperoxidase activity, mucosal zinc, iron and metallothionein concentrations. Rats received zinc sulphate, 2 mg/kg or 30 mg/kg, twice a day by gavage for 9 days, starting 3 days before the induction of colitis, or intrarectal instillation of zinc (20 mg/kg) once daily starting S hours after the induction of colitis and for 6 days thereafter.
Results. Zinc-treated rats had less diarrhoea, higher body weight and lower colonic weight than untreated rats but no effect was observed on macroscopic inflammation, adhesions, colonic distension and neutrophil infiltration of the colonic mucosa. Zinc supplementation did not affect mucosal iron and zinc concentrations or plasma zinc levels in colitic rats. Metallothionein synthesis was induced in control rats and to a lesser extent in colitic rats.
Conclusion. Zinc administration induces metallothionein synthesis but has little effect on the short-term course of experimental colitis.</description><identifier>ISSN: 1590-8658</identifier><identifier>EISSN: 1878-3562</identifier><identifier>DOI: 10.1016/S1590-8658(01)80068-2</identifier><identifier>PMID: 11346141</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Administration, Oral ; Administration, Rectal ; Analysis of Variance ; Animals ; antioxidants ; Colitis - drug therapy ; Colitis - metabolism ; Colitis - physiopathology ; Dietary Supplements ; Disease Models, Animal ; Dose-Response Relationship, Drug ; inflammation ; Intestinal Mucosa - chemistry ; Intestinal Mucosa - pathology ; Male ; metallothionein ; Metallothionein - analysis ; Metallothionein - biosynthesis ; Peroxidase - analysis ; Peroxidase - biosynthesis ; Probability ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Trace Elements - analysis ; zinc ; Zinc - administration & dosage</subject><ispartof>Digestive and liver disease, 2001-03, Vol.33 (2), p.135-139</ispartof><rights>2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-f228e77532455ab0224355141e1dfdb99fa335ebc0650feb41fead9f87810a833</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1590-8658(01)80068-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11346141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Di Leo, V.</creatorcontrib><creatorcontrib>D'Incà, R.</creatorcontrib><creatorcontrib>Barollo, M.</creatorcontrib><creatorcontrib>Tropea, A.</creatorcontrib><creatorcontrib>Fries, W.</creatorcontrib><creatorcontrib>Mazzon, E.</creatorcontrib><creatorcontrib>Irato, P.</creatorcontrib><creatorcontrib>Cecchetto, A.</creatorcontrib><creatorcontrib>Sturniolo, G.C.</creatorcontrib><title>Effect of zinc supplementation on trace elements and intestinal metallothionein concentrations in experimental colitis in the rat</title><title>Digestive and liver disease</title><addtitle>Dig Liver Dis</addtitle><description>Background and Aim. Zinc enhances cell protection against infection and injury and the healing processes themselves. We evaluated the effect of zinc supplementation at different doses on a model of experimental colitis in the rat.
Methods. Colitis, induced by intro-rectal instillation of dinitrobenzen-sulphonic acid, was assessed at 1 week by examining: general outcome and macroscopic damage, myeloperoxidase activity, mucosal zinc, iron and metallothionein concentrations. Rats received zinc sulphate, 2 mg/kg or 30 mg/kg, twice a day by gavage for 9 days, starting 3 days before the induction of colitis, or intrarectal instillation of zinc (20 mg/kg) once daily starting S hours after the induction of colitis and for 6 days thereafter.
Results. Zinc-treated rats had less diarrhoea, higher body weight and lower colonic weight than untreated rats but no effect was observed on macroscopic inflammation, adhesions, colonic distension and neutrophil infiltration of the colonic mucosa. Zinc supplementation did not affect mucosal iron and zinc concentrations or plasma zinc levels in colitic rats. Metallothionein synthesis was induced in control rats and to a lesser extent in colitic rats.
Conclusion. Zinc administration induces metallothionein synthesis but has little effect on the short-term course of experimental colitis.</description><subject>Administration, Oral</subject><subject>Administration, Rectal</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>antioxidants</subject><subject>Colitis - drug therapy</subject><subject>Colitis - metabolism</subject><subject>Colitis - physiopathology</subject><subject>Dietary Supplements</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>inflammation</subject><subject>Intestinal Mucosa - chemistry</subject><subject>Intestinal Mucosa - pathology</subject><subject>Male</subject><subject>metallothionein</subject><subject>Metallothionein - analysis</subject><subject>Metallothionein - biosynthesis</subject><subject>Peroxidase - analysis</subject><subject>Peroxidase - biosynthesis</subject><subject>Probability</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Trace Elements - analysis</subject><subject>zinc</subject><subject>Zinc - administration & dosage</subject><issn>1590-8658</issn><issn>1878-3562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctq3DAUhkVpaC7tIzRoVZqFE0m2bM0qhJBLIZBF2rWQ5SNGRSM7kiYk3eXNc8YzIcuCQOKc7z-XX4R85-yUM96ePXC5YJVqpfrJ-IlirFWV-EQOuOpUVctWfMb3O7JPDnP-y5jgrWRfyD7nddPyhh-Q1yvnwBY6OvrPR0vzepoCrCAWU_wYKZ6SjAUK22imJg7UxwK5-GgCXUExIYxliTT4SO0YLXJplmckKTxPkPxcMmA6-OLneFkCRewr2XMmZPi2u4_In-ur35e31d39za_Li7vKNqIrlRNCQdfJWjRSmp4J0dRS4g7ABzf0i4UzdS2htwxXdNA33IEZFg7t4Myouj4iP7Z1pzQ-rnF8vfLZQggmwrjOumNKoLRDUG5Bm8acEzg94fgmvWjO9MZ7PXuvN8ZqxvXsvRaoO941WPcrGD5UO7MRON8CgGs-eUg6Ww9o1-AT_oEeRv-fFm8D25bY</recordid><startdate>20010301</startdate><enddate>20010301</enddate><creator>Di Leo, V.</creator><creator>D'Incà, R.</creator><creator>Barollo, M.</creator><creator>Tropea, A.</creator><creator>Fries, W.</creator><creator>Mazzon, E.</creator><creator>Irato, P.</creator><creator>Cecchetto, A.</creator><creator>Sturniolo, G.C.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010301</creationdate><title>Effect of zinc supplementation on trace elements and intestinal metallothionein concentrations in experimental colitis in the rat</title><author>Di Leo, V. ; D'Incà, R. ; Barollo, M. ; Tropea, A. ; Fries, W. ; Mazzon, E. ; Irato, P. ; Cecchetto, A. ; Sturniolo, G.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-f228e77532455ab0224355141e1dfdb99fa335ebc0650feb41fead9f87810a833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Administration, Oral</topic><topic>Administration, Rectal</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>antioxidants</topic><topic>Colitis - drug therapy</topic><topic>Colitis - metabolism</topic><topic>Colitis - physiopathology</topic><topic>Dietary Supplements</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>inflammation</topic><topic>Intestinal Mucosa - chemistry</topic><topic>Intestinal Mucosa - pathology</topic><topic>Male</topic><topic>metallothionein</topic><topic>Metallothionein - analysis</topic><topic>Metallothionein - biosynthesis</topic><topic>Peroxidase - analysis</topic><topic>Peroxidase - biosynthesis</topic><topic>Probability</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Trace Elements - analysis</topic><topic>zinc</topic><topic>Zinc - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Di Leo, V.</creatorcontrib><creatorcontrib>D'Incà, R.</creatorcontrib><creatorcontrib>Barollo, M.</creatorcontrib><creatorcontrib>Tropea, A.</creatorcontrib><creatorcontrib>Fries, W.</creatorcontrib><creatorcontrib>Mazzon, E.</creatorcontrib><creatorcontrib>Irato, P.</creatorcontrib><creatorcontrib>Cecchetto, A.</creatorcontrib><creatorcontrib>Sturniolo, G.C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive and liver disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Di Leo, V.</au><au>D'Incà, R.</au><au>Barollo, M.</au><au>Tropea, A.</au><au>Fries, W.</au><au>Mazzon, E.</au><au>Irato, P.</au><au>Cecchetto, A.</au><au>Sturniolo, G.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of zinc supplementation on trace elements and intestinal metallothionein concentrations in experimental colitis in the rat</atitle><jtitle>Digestive and liver disease</jtitle><addtitle>Dig Liver Dis</addtitle><date>2001-03-01</date><risdate>2001</risdate><volume>33</volume><issue>2</issue><spage>135</spage><epage>139</epage><pages>135-139</pages><issn>1590-8658</issn><eissn>1878-3562</eissn><abstract>Background and Aim. Zinc enhances cell protection against infection and injury and the healing processes themselves. We evaluated the effect of zinc supplementation at different doses on a model of experimental colitis in the rat.
Methods. Colitis, induced by intro-rectal instillation of dinitrobenzen-sulphonic acid, was assessed at 1 week by examining: general outcome and macroscopic damage, myeloperoxidase activity, mucosal zinc, iron and metallothionein concentrations. Rats received zinc sulphate, 2 mg/kg or 30 mg/kg, twice a day by gavage for 9 days, starting 3 days before the induction of colitis, or intrarectal instillation of zinc (20 mg/kg) once daily starting S hours after the induction of colitis and for 6 days thereafter.
Results. Zinc-treated rats had less diarrhoea, higher body weight and lower colonic weight than untreated rats but no effect was observed on macroscopic inflammation, adhesions, colonic distension and neutrophil infiltration of the colonic mucosa. Zinc supplementation did not affect mucosal iron and zinc concentrations or plasma zinc levels in colitic rats. Metallothionein synthesis was induced in control rats and to a lesser extent in colitic rats.
Conclusion. Zinc administration induces metallothionein synthesis but has little effect on the short-term course of experimental colitis.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>11346141</pmid><doi>10.1016/S1590-8658(01)80068-2</doi><tpages>5</tpages></addata></record> |
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| subjects | Administration, Oral Administration, Rectal Analysis of Variance Animals antioxidants Colitis - drug therapy Colitis - metabolism Colitis - physiopathology Dietary Supplements Disease Models, Animal Dose-Response Relationship, Drug inflammation Intestinal Mucosa - chemistry Intestinal Mucosa - pathology Male metallothionein Metallothionein - analysis Metallothionein - biosynthesis Peroxidase - analysis Peroxidase - biosynthesis Probability Random Allocation Rats Rats, Sprague-Dawley Trace Elements - analysis zinc Zinc - administration & dosage |
| title | Effect of zinc supplementation on trace elements and intestinal metallothionein concentrations in experimental colitis in the rat |
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