Relaxant effects of pyranocoumarin compounds isolated from a Chinese medical plant, Bai-Hua Qian-Hu, on isolated rabbit tracheas and pulmonary arteries
Qian-Hu is a well-known traditional Chinese medicine used for the treatment of respiratory diseases and pulmonary hypertension. We compared the relaxant effects of pyranocoumarin compounds, including (+)-praeruptorin A (Pra-C), Pd-Ia (=(+/-)-praeruptorin A), pteryxin, peucedanocoumarin II (P-II) and...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 1999, Vol.22 (9), p.984-987 |
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| creator | ZHAO, N.-C JIN, W.-B ZHANG, X.-H GUAN, F.-L SUN, Y.-B ADACHI, H OKUYAMA, T |
| description | Qian-Hu is a well-known traditional Chinese medicine used for the treatment of respiratory diseases and pulmonary hypertension. We compared the relaxant effects of pyranocoumarin compounds, including (+)-praeruptorin A (Pra-C), Pd-Ia (=(+/-)-praeruptorin A), pteryxin, peucedanocoumarin II (P-II) and 8-methoxy-psoralen (8-MOP) purified from Bai-Hua Qian-Hu (BQ) in isolated rabbit tracheas and pulmonary arteries. Pra-C, pteryxin and Pd-Ia produced significant relaxant effects in tracheal preparations constricted with 40 mM KCl or 10 microM acetylcholine. The relaxant response to Pra-C, pteryxin or Pd-Ia in preparations constricted with KCl was significantly more potent than that in preparations constricted with acetylcholine. Pra-C, pteryxin or Pd-Ia at a concentration of 30 microM completely relaxed tracheas constricted with 40 mM KCl, whereas P-II at the same concentration showed only partial relaxation. In pulmonary arterial preparations, 8-MOP produced a significant relaxant effect on contractions by 10 microM phenylephrine, without any effect on the contraction by 40 mM KCl. These results suggest that Pd-Ia, pteryxin and Pra-C for their calcium antagonistic action, and 8-MOP for its inhibitory effect on contraction induced by phenylephrine, may be the active principles of BQ for relaxing the smooth muscle of tracheas and pulmonary arteries, and the principle may produce a synergistic effect. |
| doi_str_mv | 10.1248/bpb.22.984 |
| format | Article |
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We compared the relaxant effects of pyranocoumarin compounds, including (+)-praeruptorin A (Pra-C), Pd-Ia (=(+/-)-praeruptorin A), pteryxin, peucedanocoumarin II (P-II) and 8-methoxy-psoralen (8-MOP) purified from Bai-Hua Qian-Hu (BQ) in isolated rabbit tracheas and pulmonary arteries. Pra-C, pteryxin and Pd-Ia produced significant relaxant effects in tracheal preparations constricted with 40 mM KCl or 10 microM acetylcholine. The relaxant response to Pra-C, pteryxin or Pd-Ia in preparations constricted with KCl was significantly more potent than that in preparations constricted with acetylcholine. Pra-C, pteryxin or Pd-Ia at a concentration of 30 microM completely relaxed tracheas constricted with 40 mM KCl, whereas P-II at the same concentration showed only partial relaxation. In pulmonary arterial preparations, 8-MOP produced a significant relaxant effect on contractions by 10 microM phenylephrine, without any effect on the contraction by 40 mM KCl. These results suggest that Pd-Ia, pteryxin and Pra-C for their calcium antagonistic action, and 8-MOP for its inhibitory effect on contraction induced by phenylephrine, may be the active principles of BQ for relaxing the smooth muscle of tracheas and pulmonary arteries, and the principle may produce a synergistic effect.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.22.984</identifier><identifier>PMID: 10513627</identifier><language>eng</language><publisher>Tokyo: Maruzen</publisher><subject>Animals ; Biological and medical sciences ; Bronchodilator Agents - pharmacology ; Coumarins - isolation & purification ; Coumarins - pharmacology ; Drugs, Chinese Herbal - chemistry ; Drugs, Chinese Herbal - pharmacology ; Female ; General pharmacology ; In Vitro Techniques ; Male ; Medical sciences ; Methoxsalen - pharmacology ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plants, Medicinal - chemistry ; Pulmonary Artery - drug effects ; Pulmonary Artery - physiology ; Rabbits ; Trachea - drug effects ; Trachea - physiology ; Vasodilator Agents - pharmacology</subject><ispartof>Biological & pharmaceutical bulletin, 1999, Vol.22 (9), p.984-987</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-798690cd1ac7d9a622cc2d7eeb00832bed4b5c400597f6d34a3d1cb613d8619d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1993752$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10513627$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZHAO, N.-C</creatorcontrib><creatorcontrib>JIN, W.-B</creatorcontrib><creatorcontrib>ZHANG, X.-H</creatorcontrib><creatorcontrib>GUAN, F.-L</creatorcontrib><creatorcontrib>SUN, Y.-B</creatorcontrib><creatorcontrib>ADACHI, H</creatorcontrib><creatorcontrib>OKUYAMA, T</creatorcontrib><title>Relaxant effects of pyranocoumarin compounds isolated from a Chinese medical plant, Bai-Hua Qian-Hu, on isolated rabbit tracheas and pulmonary arteries</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Qian-Hu is a well-known traditional Chinese medicine used for the treatment of respiratory diseases and pulmonary hypertension. We compared the relaxant effects of pyranocoumarin compounds, including (+)-praeruptorin A (Pra-C), Pd-Ia (=(+/-)-praeruptorin A), pteryxin, peucedanocoumarin II (P-II) and 8-methoxy-psoralen (8-MOP) purified from Bai-Hua Qian-Hu (BQ) in isolated rabbit tracheas and pulmonary arteries. Pra-C, pteryxin and Pd-Ia produced significant relaxant effects in tracheal preparations constricted with 40 mM KCl or 10 microM acetylcholine. The relaxant response to Pra-C, pteryxin or Pd-Ia in preparations constricted with KCl was significantly more potent than that in preparations constricted with acetylcholine. Pra-C, pteryxin or Pd-Ia at a concentration of 30 microM completely relaxed tracheas constricted with 40 mM KCl, whereas P-II at the same concentration showed only partial relaxation. In pulmonary arterial preparations, 8-MOP produced a significant relaxant effect on contractions by 10 microM phenylephrine, without any effect on the contraction by 40 mM KCl. These results suggest that Pd-Ia, pteryxin and Pra-C for their calcium antagonistic action, and 8-MOP for its inhibitory effect on contraction induced by phenylephrine, may be the active principles of BQ for relaxing the smooth muscle of tracheas and pulmonary arteries, and the principle may produce a synergistic effect.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bronchodilator Agents - pharmacology</subject><subject>Coumarins - isolation & purification</subject><subject>Coumarins - pharmacology</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Female</subject><subject>General pharmacology</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methoxsalen - pharmacology</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plants, Medicinal - chemistry</subject><subject>Pulmonary Artery - drug effects</subject><subject>Pulmonary Artery - physiology</subject><subject>Rabbits</subject><subject>Trachea - drug effects</subject><subject>Trachea - physiology</subject><subject>Vasodilator Agents - pharmacology</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkU2LFDEQhoMo7uzqxR8gOYiHZXvMR6fTOa6DusKCKHpuKkk1G-lO2qQbnF_i3zUyA-up6vDUC_W8hLzibM9F27-zi90LsTd9-4TsuGx1owRXT8mOGd43HVf9Bbks5SdjTDMhn5MLzhSXndA78ucbTvAb4kpxHNGthaaRLscMMbm0zZBDpC7NS9qiLzSUNMGKno45zRTo4SFELEhn9MHBRJepJt3Q9xCauw3o1wCxLjc0xcfTDNaGla4Z3ANCoRA9XbZpThHykUJeMQcsL8izEaaCL8_zivz4-OH74a65__Lp8-H2vnGqZWujTd8Z5jwHp72BTgjnhNeIlrFeCou-tcq1jCmjx87LFqTnznZc-r7jxssr8vaUu-T0a8OyDnMoDqf6CKatDJr1QknGKnh9Al1OpWQchyWH6uc4cDb8q2GoNQxCDLWGCr8-p262uvkPPXmvwJszAKWKG6tvF8ojZ4zUSsi_uR2SPg</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>ZHAO, N.-C</creator><creator>JIN, W.-B</creator><creator>ZHANG, X.-H</creator><creator>GUAN, F.-L</creator><creator>SUN, Y.-B</creator><creator>ADACHI, H</creator><creator>OKUYAMA, T</creator><general>Maruzen</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1999</creationdate><title>Relaxant effects of pyranocoumarin compounds isolated from a Chinese medical plant, Bai-Hua Qian-Hu, on isolated rabbit tracheas and pulmonary arteries</title><author>ZHAO, N.-C ; JIN, W.-B ; ZHANG, X.-H ; GUAN, F.-L ; SUN, Y.-B ; ADACHI, H ; OKUYAMA, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-798690cd1ac7d9a622cc2d7eeb00832bed4b5c400597f6d34a3d1cb613d8619d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bronchodilator Agents - pharmacology</topic><topic>Coumarins - isolation & purification</topic><topic>Coumarins - pharmacology</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Female</topic><topic>General pharmacology</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methoxsalen - pharmacology</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plants, Medicinal - chemistry</topic><topic>Pulmonary Artery - drug effects</topic><topic>Pulmonary Artery - physiology</topic><topic>Rabbits</topic><topic>Trachea - drug effects</topic><topic>Trachea - physiology</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ZHAO, N.-C</creatorcontrib><creatorcontrib>JIN, W.-B</creatorcontrib><creatorcontrib>ZHANG, X.-H</creatorcontrib><creatorcontrib>GUAN, F.-L</creatorcontrib><creatorcontrib>SUN, Y.-B</creatorcontrib><creatorcontrib>ADACHI, H</creatorcontrib><creatorcontrib>OKUYAMA, T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ZHAO, N.-C</au><au>JIN, W.-B</au><au>ZHANG, X.-H</au><au>GUAN, F.-L</au><au>SUN, Y.-B</au><au>ADACHI, H</au><au>OKUYAMA, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relaxant effects of pyranocoumarin compounds isolated from a Chinese medical plant, Bai-Hua Qian-Hu, on isolated rabbit tracheas and pulmonary arteries</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>1999</date><risdate>1999</risdate><volume>22</volume><issue>9</issue><spage>984</spage><epage>987</epage><pages>984-987</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Qian-Hu is a well-known traditional Chinese medicine used for the treatment of respiratory diseases and pulmonary hypertension. We compared the relaxant effects of pyranocoumarin compounds, including (+)-praeruptorin A (Pra-C), Pd-Ia (=(+/-)-praeruptorin A), pteryxin, peucedanocoumarin II (P-II) and 8-methoxy-psoralen (8-MOP) purified from Bai-Hua Qian-Hu (BQ) in isolated rabbit tracheas and pulmonary arteries. Pra-C, pteryxin and Pd-Ia produced significant relaxant effects in tracheal preparations constricted with 40 mM KCl or 10 microM acetylcholine. The relaxant response to Pra-C, pteryxin or Pd-Ia in preparations constricted with KCl was significantly more potent than that in preparations constricted with acetylcholine. Pra-C, pteryxin or Pd-Ia at a concentration of 30 microM completely relaxed tracheas constricted with 40 mM KCl, whereas P-II at the same concentration showed only partial relaxation. In pulmonary arterial preparations, 8-MOP produced a significant relaxant effect on contractions by 10 microM phenylephrine, without any effect on the contraction by 40 mM KCl. These results suggest that Pd-Ia, pteryxin and Pra-C for their calcium antagonistic action, and 8-MOP for its inhibitory effect on contraction induced by phenylephrine, may be the active principles of BQ for relaxing the smooth muscle of tracheas and pulmonary arteries, and the principle may produce a synergistic effect.</abstract><cop>Tokyo</cop><pub>Maruzen</pub><pmid>10513627</pmid><doi>10.1248/bpb.22.984</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Biological and medical sciences Bronchodilator Agents - pharmacology Coumarins - isolation & purification Coumarins - pharmacology Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacology Female General pharmacology In Vitro Techniques Male Medical sciences Methoxsalen - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Pulmonary Artery - drug effects Pulmonary Artery - physiology Rabbits Trachea - drug effects Trachea - physiology Vasodilator Agents - pharmacology |
| title | Relaxant effects of pyranocoumarin compounds isolated from a Chinese medical plant, Bai-Hua Qian-Hu, on isolated rabbit tracheas and pulmonary arteries |
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