Cytokine induction in fetal rat brains and brain injury in neonatal rats after maternal lipopolysaccharide administration

Induction of proinflammatory cytokines has been proposed to be a link between prenatal maternal intrauterine infection and neonatal brain damage. It is known that the endotoxin, lipopolysaccharide (LPS), released during bacterial infection crosses the placenta. Cytokine induction in the fetal rat br...

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Veröffentlicht in:	Pediatric research 2000, Vol.47 (1), p.64-72
Hauptverfasser:	ZHENGWEI CAI, PAN, Z.-L, YI PANG, EVANS, O. B, RHODES, P. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Blotting, Western Brain - drug effects Brain - embryology Brain - metabolism Diseases of mother, fetus and pregnancy DNA Primers Female Fetus - drug effects Glial Fibrillary Acidic Protein - metabolism Gynecology. Andrology. Obstetrics Immunohistochemistry Interleukin-1 - biosynthesis Interleukin-1 - genetics Lipopolysaccharides - pharmacology Medical sciences Pregnancy Pregnancy. Fetus. Placenta Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Messenger - genetics Survival Rate Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics
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