Enhanced Synchronous Spectrofluorometric Determination of Tetracycline in Blood Serum by Chemometric Analysis. Comparison of Partial Least-Squares and Hybrid Linear Analysis Calibrations

Tetracycline has been determined in human serum samples by a combination of: (1) synchronous fluorescence spectra of whole sera treated with Mg2+, and (2) the multivariate calibration methods of partial least-squares (PLS-1) and a variant of the recently introduced hybrid linear analysis (HLA), whi...

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Veröffentlicht in:	Analytical chemistry (Washington) 1999-10, Vol.71 (19), p.4361-4368
Hauptverfasser:	Goicoechea, Héctor C, Olivieri, Alejandro C
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biological and medical sciences Blood Calibration Chemistry Drugs General pharmacology Humans Least-Squares Analysis Linear Models Magnesium - blood Magnesium - chemistry Magnesium - metabolism Medical sciences Multivariate Analysis Pharmacology. Drug treatments Sensitivity and Specificity Spectrometry, Fluorescence - methods Tetracycline - blood Tetracycline - chemistry Tetracycline - metabolism
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