Enhanced Synchronous Spectrofluorometric Determination of Tetracycline in Blood Serum by Chemometric Analysis. Comparison of Partial Least-Squares and Hybrid Linear Analysis Calibrations
Tetracycline has been determined in human serum samples by a combination of: (1) synchronous fluorescence spectra of whole sera treated with Mg2+, and (2) the multivariate calibration methods of partial least-squares (PLS-1) and a variant of the recently introduced hybrid linear analysis (HLA), whi...
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| Veröffentlicht in: | Analytical chemistry (Washington) 1999-10, Vol.71 (19), p.4361-4368 |
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| creator | Goicoechea, Héctor C Olivieri, Alejandro C |
| description | Tetracycline has been determined in human serum samples by a combination of: (1) synchronous fluorescence spectra of whole sera treated with Mg2+, and (2) the multivariate calibration methods of partial least-squares (PLS-1) and a variant of the recently introduced hybrid linear analysis (HLA), which does not require the knowledge of pure-component spectra. The calibration set was designed with 50 sera spiked with concentrations of tetracycline in the range 0.0−4.0 μg mL-1. Studies concerning validation, precision, accuracy and figures of merit (selectivity, sensitivity and limit of determination) were also carried out. A novel wavelength-selection procedure was applied to minimize the effect of nonmodeled interferents present in serum samples containing bilirubin, triglycerides, and salicylate. Overall, the performance of the newly developed HLA approach seems to be better than that of PLS-1. |
| doi_str_mv | 10.1021/ac990374e |
| format | Article |
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Comparison of Partial Least-Squares and Hybrid Linear Analysis Calibrations</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. Chem</addtitle><description>Tetracycline has been determined in human serum samples by a combination of: (1) synchronous fluorescence spectra of whole sera treated with Mg2+, and (2) the multivariate calibration methods of partial least-squares (PLS-1) and a variant of the recently introduced hybrid linear analysis (HLA), which does not require the knowledge of pure-component spectra. The calibration set was designed with 50 sera spiked with concentrations of tetracycline in the range 0.0−4.0 μg mL-1. Studies concerning validation, precision, accuracy and figures of merit (selectivity, sensitivity and limit of determination) were also carried out. A novel wavelength-selection procedure was applied to minimize the effect of nonmodeled interferents present in serum samples containing bilirubin, triglycerides, and salicylate. Overall, the performance of the newly developed HLA approach seems to be better than that of PLS-1.</description><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Calibration</subject><subject>Chemistry</subject><subject>Drugs</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Least-Squares Analysis</subject><subject>Linear Models</subject><subject>Magnesium - blood</subject><subject>Magnesium - chemistry</subject><subject>Magnesium - metabolism</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Pharmacology. Drug treatments</subject><subject>Sensitivity and Specificity</subject><subject>Spectrometry, Fluorescence - methods</subject><subject>Tetracycline - blood</subject><subject>Tetracycline - chemistry</subject><subject>Tetracycline - metabolism</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkcFu1DAQhiMEokvhwAsgCwEShxTb2dibY7stLGglKu0iVVysiTPWuiT21k4k8mo8HYYsWwSnkWe--fWP_yx7zugZo5y9A11VtJBzfJDNWMlpLhYL_jCbUUqLnEtKT7InMd5Syhhl4nF2wmjJJCvZLPtx5XbgNDZkMzq9C975IZLNHnUfvGkHH3yHfbCaXGKPobMOeusd8YZsUx_0qFvrkFhHLlrvkwyGoSP1SJY77P7snjtox2jjGVn6bg_BxkniGkJvoSVrhNjnm7sBAkYCriGrsQ62IeukDeG4T5bQ2jr8thCfZo8MtBGfHepp9uX91Xa5ytefP3xcnq9zmEvW58JUUhSllFygkXNmFiiquaCVqXVdNAhpaDgi0wYKXZumKbBkpaHpVYqSF6fZm0l3H_zdgLFXnY0a2xYcps9Ski44F3ORwJf_gLd-CMl6VJzJhSx4yRL0doJ08DEGNGofbAdhVIyqX2mqY5qJfXEQHOoOm7_IKb4EvDoAEDW0JqQobbzn0uWyKhKWT5iNPX4_jiF8U0IWslTb641aXXy6uVxvb9TXxL-eeNDx_ob__f0EohzGbw</recordid><startdate>19991001</startdate><enddate>19991001</enddate><creator>Goicoechea, Héctor C</creator><creator>Olivieri, Alejandro C</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19991001</creationdate><title>Enhanced Synchronous Spectrofluorometric Determination of Tetracycline in Blood Serum by Chemometric Analysis. Comparison of Partial Least-Squares and Hybrid Linear Analysis Calibrations</title><author>Goicoechea, Héctor C ; Olivieri, Alejandro C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a471t-6f976357726ef741f8e694609fbcb3dea635f2ee1cfa3cbfdd3e515f0a3c56523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Analysis</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Calibration</topic><topic>Chemistry</topic><topic>Drugs</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Least-Squares Analysis</topic><topic>Linear Models</topic><topic>Magnesium - blood</topic><topic>Magnesium - chemistry</topic><topic>Magnesium - metabolism</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Pharmacology. Drug treatments</topic><topic>Sensitivity and Specificity</topic><topic>Spectrometry, Fluorescence - methods</topic><topic>Tetracycline - blood</topic><topic>Tetracycline - chemistry</topic><topic>Tetracycline - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goicoechea, Héctor C</creatorcontrib><creatorcontrib>Olivieri, Alejandro C</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goicoechea, Héctor C</au><au>Olivieri, Alejandro C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced Synchronous Spectrofluorometric Determination of Tetracycline in Blood Serum by Chemometric Analysis. Comparison of Partial Least-Squares and Hybrid Linear Analysis Calibrations</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>1999-10-01</date><risdate>1999</risdate><volume>71</volume><issue>19</issue><spage>4361</spage><epage>4368</epage><pages>4361-4368</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><coden>ANCHAM</coden><abstract>Tetracycline has been determined in human serum samples by a combination of: (1) synchronous fluorescence spectra of whole sera treated with Mg2+, and (2) the multivariate calibration methods of partial least-squares (PLS-1) and a variant of the recently introduced hybrid linear analysis (HLA), which does not require the knowledge of pure-component spectra. The calibration set was designed with 50 sera spiked with concentrations of tetracycline in the range 0.0−4.0 μg mL-1. Studies concerning validation, precision, accuracy and figures of merit (selectivity, sensitivity and limit of determination) were also carried out. A novel wavelength-selection procedure was applied to minimize the effect of nonmodeled interferents present in serum samples containing bilirubin, triglycerides, and salicylate. Overall, the performance of the newly developed HLA approach seems to be better than that of PLS-1.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>10517151</pmid><doi>10.1021/ac990374e</doi><tpages>8</tpages></addata></record> |
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| ispartof | Analytical chemistry (Washington), 1999-10, Vol.71 (19), p.4361-4368 |
| issn | 0003-2700 1520-6882 |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Analysis Biological and medical sciences Blood Calibration Chemistry Drugs General pharmacology Humans Least-Squares Analysis Linear Models Magnesium - blood Magnesium - chemistry Magnesium - metabolism Medical sciences Multivariate Analysis Pharmacology. Drug treatments Sensitivity and Specificity Spectrometry, Fluorescence - methods Tetracycline - blood Tetracycline - chemistry Tetracycline - metabolism |
| title | Enhanced Synchronous Spectrofluorometric Determination of Tetracycline in Blood Serum by Chemometric Analysis. Comparison of Partial Least-Squares and Hybrid Linear Analysis Calibrations |
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