Effects of ovarian input on GnRH and LH secretion immediately postovulation in pony mares
The potential involvement of ovarian factors in regulating GnRH and LH postovulation was studied in ovarian intact (Group 1; n=3) and ovariectomized (OVX; Group 2; n=3) mares (OVX within 12 hr of ovulation). Blood samples were collected every 10 min for 6 hr from jugular vein (JV) and intercavernous...
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| Veröffentlicht in: | Theriogenology 2001-03, Vol.55 (5), p.1095-1106 |
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| container_title | Theriogenology |
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| creator | Greaves, H.E. Kalariotes, V. Cleaver, B.D. Porter, M.B. Sharp, D.C. |
| description | The potential involvement of ovarian factors in regulating GnRH and LH postovulation was studied in ovarian intact (Group 1; n=3) and ovariectomized (OVX; Group 2; n=3) mares (OVX within 12 hr of ovulation). Blood samples were collected every 10 min for 6 hr from jugular vein (JV) and intercavernous sinus (ICS) during estrus and on Day 8 postovulation for LH and GnRH analysis. Additionally, JV samples were collected twice daily (12-hr intervals) for 30 days for LH and progesterone (P
4) analysis. A significant treatment × day effect (P |
| doi_str_mv | 10.1016/S0093-691X(01)00469-1 |
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4) analysis. A significant treatment × day effect (P<0.0001) describes declining plasma LH concentration in intact mares, and regression analysis indicated that response curves were not parallel (P<0.001). Plasma LH concentrations remained elevated in OVX mares. LH increased further in OVX mares by Day 8 post-OVX (P<0.06), reflecting the increased (P<0.07) LH episode amplitude. GnRH decreased from estrus to Day 8 in both groups reflecting an effect of sampling period (P<0.03). GnRH episode amplitude declined (P<0.08) from estrus (62.8±3.1 pg/mL) to Day 8 (46.3±3.1 pg/mL) in OVX mares, but not in control mares (intact estrus, 36.5±6.4; intact Day 8, 37.5±7.3; OVX estrus, 62.8±3.1; OVX Day 8, 46.3±3.1 pg/mL). In conclusion, we propose that postovulatory LH decline requires ovarian feedback in mares, and that OVX alters GnRH secretory dynamics such that LH concentrations does not decline postovulation and, in fact, is further elevated with time after OVX.]]></description><identifier>ISSN: 0093-691X</identifier><identifier>EISSN: 1879-3231</identifier><identifier>DOI: 10.1016/S0093-691X(01)00469-1</identifier><identifier>PMID: 11322237</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Feedback ; Female ; GnRH ; Gonadotropin-Releasing Hormone - blood ; Gonadotropin-Releasing Hormone - metabolism ; Horses - physiology ; Least-Squares Analysis ; LH secretion ; Luteinizing Hormone - blood ; Luteinizing Hormone - metabolism ; Ovariectomy - veterinary ; ovary ; Ovary - physiology ; Ovulation - physiology ; Progesterone - blood ; Random Allocation</subject><ispartof>Theriogenology, 2001-03, Vol.55 (5), p.1095-1106</ispartof><rights>2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c309t-964bea4dd2369cb4af50b25a525683da4b77a5b013023a48064e3d2ed71e3c2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0093-691X(01)00469-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11322237$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Greaves, H.E.</creatorcontrib><creatorcontrib>Kalariotes, V.</creatorcontrib><creatorcontrib>Cleaver, B.D.</creatorcontrib><creatorcontrib>Porter, M.B.</creatorcontrib><creatorcontrib>Sharp, D.C.</creatorcontrib><title>Effects of ovarian input on GnRH and LH secretion immediately postovulation in pony mares</title><title>Theriogenology</title><addtitle>Theriogenology</addtitle><description><![CDATA[The potential involvement of ovarian factors in regulating GnRH and LH postovulation was studied in ovarian intact (Group 1; n=3) and ovariectomized (OVX; Group 2; n=3) mares (OVX within 12 hr of ovulation). Blood samples were collected every 10 min for 6 hr from jugular vein (JV) and intercavernous sinus (ICS) during estrus and on Day 8 postovulation for LH and GnRH analysis. Additionally, JV samples were collected twice daily (12-hr intervals) for 30 days for LH and progesterone (P
4) analysis. A significant treatment × day effect (P<0.0001) describes declining plasma LH concentration in intact mares, and regression analysis indicated that response curves were not parallel (P<0.001). Plasma LH concentrations remained elevated in OVX mares. LH increased further in OVX mares by Day 8 post-OVX (P<0.06), reflecting the increased (P<0.07) LH episode amplitude. GnRH decreased from estrus to Day 8 in both groups reflecting an effect of sampling period (P<0.03). GnRH episode amplitude declined (P<0.08) from estrus (62.8±3.1 pg/mL) to Day 8 (46.3±3.1 pg/mL) in OVX mares, but not in control mares (intact estrus, 36.5±6.4; intact Day 8, 37.5±7.3; OVX estrus, 62.8±3.1; OVX Day 8, 46.3±3.1 pg/mL). In conclusion, we propose that postovulatory LH decline requires ovarian feedback in mares, and that OVX alters GnRH secretory dynamics such that LH concentrations does not decline postovulation and, in fact, is further elevated with time after OVX.]]></description><subject>Animals</subject><subject>Feedback</subject><subject>Female</subject><subject>GnRH</subject><subject>Gonadotropin-Releasing Hormone - blood</subject><subject>Gonadotropin-Releasing Hormone - metabolism</subject><subject>Horses - physiology</subject><subject>Least-Squares Analysis</subject><subject>LH secretion</subject><subject>Luteinizing Hormone - blood</subject><subject>Luteinizing Hormone - metabolism</subject><subject>Ovariectomy - veterinary</subject><subject>ovary</subject><subject>Ovary - physiology</subject><subject>Ovulation - physiology</subject><subject>Progesterone - blood</subject><subject>Random Allocation</subject><issn>0093-691X</issn><issn>1879-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rGzEQQEVJaZy0P6FBp5Actp2RdrXeUwgmiQuGQpNCexJa7SworCVH2jX430eOTXrsaWDmzddj7CvCNwRU3x8BGlmoBv9cAV4DlKop8AOb4bxuCikknrDZO3LKzlJ6BgCpFH5ip4hSCCHrGft71_dkx8RDz8PWRGc8d34zjTx4_uB_LbnxHV8teSIbaXQ569Zr6pwZadjxTUhj2E6DOVR8TvgdX5tI6TP72Jsh0ZdjPGe_7--eFsti9fPhx-J2VVgJzVg0qmzJlF0npGpsW5q-glZUphKVmsvOlG1dm6oFlCCkKeegSpKdoK5GklZYec4uD3M3MbxMlEa9dsnSMBhPYUq6hrnARmAGqwNoY0gpUq830eVTdxpB753qN6d6L0wD6jenet93cVwwtfnzf11HiRm4OQCU39w6ijpZR95mSzG71V1w_1nxCvKyhrg</recordid><startdate>20010315</startdate><enddate>20010315</enddate><creator>Greaves, H.E.</creator><creator>Kalariotes, V.</creator><creator>Cleaver, B.D.</creator><creator>Porter, M.B.</creator><creator>Sharp, D.C.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010315</creationdate><title>Effects of ovarian input on GnRH and LH secretion immediately postovulation in pony mares</title><author>Greaves, H.E. ; Kalariotes, V. ; Cleaver, B.D. ; Porter, M.B. ; Sharp, D.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-964bea4dd2369cb4af50b25a525683da4b77a5b013023a48064e3d2ed71e3c2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Feedback</topic><topic>Female</topic><topic>GnRH</topic><topic>Gonadotropin-Releasing Hormone - blood</topic><topic>Gonadotropin-Releasing Hormone - metabolism</topic><topic>Horses - physiology</topic><topic>Least-Squares Analysis</topic><topic>LH secretion</topic><topic>Luteinizing Hormone - blood</topic><topic>Luteinizing Hormone - metabolism</topic><topic>Ovariectomy - veterinary</topic><topic>ovary</topic><topic>Ovary - physiology</topic><topic>Ovulation - physiology</topic><topic>Progesterone - blood</topic><topic>Random Allocation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Greaves, H.E.</creatorcontrib><creatorcontrib>Kalariotes, V.</creatorcontrib><creatorcontrib>Cleaver, B.D.</creatorcontrib><creatorcontrib>Porter, M.B.</creatorcontrib><creatorcontrib>Sharp, D.C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Theriogenology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Greaves, H.E.</au><au>Kalariotes, V.</au><au>Cleaver, B.D.</au><au>Porter, M.B.</au><au>Sharp, D.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of ovarian input on GnRH and LH secretion immediately postovulation in pony mares</atitle><jtitle>Theriogenology</jtitle><addtitle>Theriogenology</addtitle><date>2001-03-15</date><risdate>2001</risdate><volume>55</volume><issue>5</issue><spage>1095</spage><epage>1106</epage><pages>1095-1106</pages><issn>0093-691X</issn><eissn>1879-3231</eissn><abstract><![CDATA[The potential involvement of ovarian factors in regulating GnRH and LH postovulation was studied in ovarian intact (Group 1; n=3) and ovariectomized (OVX; Group 2; n=3) mares (OVX within 12 hr of ovulation). Blood samples were collected every 10 min for 6 hr from jugular vein (JV) and intercavernous sinus (ICS) during estrus and on Day 8 postovulation for LH and GnRH analysis. Additionally, JV samples were collected twice daily (12-hr intervals) for 30 days for LH and progesterone (P
4) analysis. A significant treatment × day effect (P<0.0001) describes declining plasma LH concentration in intact mares, and regression analysis indicated that response curves were not parallel (P<0.001). Plasma LH concentrations remained elevated in OVX mares. LH increased further in OVX mares by Day 8 post-OVX (P<0.06), reflecting the increased (P<0.07) LH episode amplitude. GnRH decreased from estrus to Day 8 in both groups reflecting an effect of sampling period (P<0.03). GnRH episode amplitude declined (P<0.08) from estrus (62.8±3.1 pg/mL) to Day 8 (46.3±3.1 pg/mL) in OVX mares, but not in control mares (intact estrus, 36.5±6.4; intact Day 8, 37.5±7.3; OVX estrus, 62.8±3.1; OVX Day 8, 46.3±3.1 pg/mL). In conclusion, we propose that postovulatory LH decline requires ovarian feedback in mares, and that OVX alters GnRH secretory dynamics such that LH concentrations does not decline postovulation and, in fact, is further elevated with time after OVX.]]></abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11322237</pmid><doi>10.1016/S0093-691X(01)00469-1</doi><tpages>12</tpages></addata></record> |
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| subjects | Animals Feedback Female GnRH Gonadotropin-Releasing Hormone - blood Gonadotropin-Releasing Hormone - metabolism Horses - physiology Least-Squares Analysis LH secretion Luteinizing Hormone - blood Luteinizing Hormone - metabolism Ovariectomy - veterinary ovary Ovary - physiology Ovulation - physiology Progesterone - blood Random Allocation |
| title | Effects of ovarian input on GnRH and LH secretion immediately postovulation in pony mares |
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