A quartz crystal resonant sensor (QCRS) study of HSA-drug interactions

Human serum albumin (HSA) was immobilised on the gold surface of a quartz crystal resonance sensor (QCRS) and exposed to warfarin and diazepam. Distinct decreases in frequency of differing magnitudes were observed upon exposure of the protein to each of the compounds suggesting strongly that a ligan...

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Veröffentlicht in:	Analyst (London) 2001-04, Vol.126 (4), p.426-428
Hauptverfasser:	PAVEY, Karl D, LYLE, A. Emma-Louise, OLLIFF, Cedric J, PAUL, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticoagulants - metabolism Binding Sites Biological and medical sciences Cattle Diazepam - metabolism Flow Injection Analysis General pharmacology Gold Humans Hypnotics and Sedatives - metabolism Medical sciences Oscillometry - methods Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Protein Binding Quartz quartz crystal resonance sensor Serum Albumin - metabolism Serum Albumin, Bovine - metabolism warfarin Warfarin - metabolism
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