VEGF levels in asthmatic airways do not correlate with plasma extravasation
Background Vascular permeability/vascular endothelial growth factor (VEGF) is a multifunctional cytokine which plays a role in chronic inflammation and angiogenesis. Its expression in bronchoalveolar lavage (BAL) has not been determined although VEGF may be relevant to the pathophysiology of asthma...
Gespeichert in:
| Veröffentlicht in: | Clinical and experimental allergy 1999-10, Vol.29 (10), p.1390-1394 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1394 |
|---|---|
| container_issue | 10 |
| container_start_page | 1390 |
| container_title | Clinical and experimental allergy |
| container_volume | 29 |
| creator | DEMOLY, P MALY, F. E MAUTINO, G GRAD, S GOUGAT, C SAHLA, H GODARD, P BOUSQUET, J |
| description | Background
Vascular permeability/vascular endothelial growth factor (VEGF) is a multifunctional cytokine which plays a role in chronic inflammation and angiogenesis. Its expression in bronchoalveolar lavage (BAL) has not been determined although VEGF may be relevant to the pathophysiology of asthma in which oedema is an important feature.
Methods
We studied VEGF, albumin and IgA immunoreactive levels in the BAL fluids obtained from 27 chronic stable asthmatics, nine untreated chronic bronchitis patients and 15 control subjects.
Results
BAL fluid levels of VEGF and VEGF normalized to IgA were not significantly different in any patient group. Both asthmatic steroid‐ and non‐steroid‐treated groups had significantly lower albumin levels in their BAL fluids explaining most of the 179% increased VEGF normalized to albumin ratios in non‐steroid treated asthmatics. Moreover, VEGF and albumin markers correlated in control subjects (r = 0.73, P = 0.006) and in chronic bronchitics (r = 0.75, P = 0.03, Spearman test), but not in asthmatics. VEGF was inversely correlated with asthma severity (GINA/NHLBI scores) in non‐steroid treated asthmatics (τ = − 0.52, P = 0.009, Kendall test).
Conclusions
Thus, the potential role of VEGF in asthma requires further studies on bronchial biopsies and induced sputum. |
| doi_str_mv | 10.1046/j.1365-2222.1999.00544.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70820270</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70820270</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4874-6b85748cf4ce91b914b331d5d45b47a004eb44f191601e614e838008c0e2d9623</originalsourceid><addsrcrecordid>eNqNkF1v0zAUQC0EYmXwF5CFEG8J1_GNY0u8jKrrJiYQErBHy3EcLSUfnZ2u7b_HIdVAPOEXW_I519YhhDJIGaB4v0kZF3mSxZUypVQKkCOmhydk8XjxlCxA5ZgUUuEZeRHCBgB4ruRzcsYgzwAELMinH6v1JW3dg2sDbXpqwnjXmbGx1DR-b46BVgPth5HawXvXmtHRfTPe0W1rQmeoO4zePJgQjaF_SZ7Vpg3u1Wk_J98vV9-WV8nNl_X18uImsSgLTEQp8wKlrdE6xUrFsOScVXmFeYmFAUBXItZMMQHMCYZOcgkgLbisUiLj5-TdPHfrh_udC6PummBd25reDbugC5AZZAVE8M0_4GbY-T7-TcdqUnLBp2lyhqwfQvCu1lvfdMYfNQM91dYbPUXVU9TJU_p3bX2I6uvT_F3Zueovcc4bgbcnwARr2tqb3jbhD6cEV0xF7MOM7ZvWHf_7fb1cXcRD1JNZb8LoDo-68T-1KHiR69vPa42IH1lx-1Wv-S-Bz6ce</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>199883632</pqid></control><display><type>article</type><title>VEGF levels in asthmatic airways do not correlate with plasma extravasation</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>DEMOLY, P ; MALY, F. E ; MAUTINO, G ; GRAD, S ; GOUGAT, C ; SAHLA, H ; GODARD, P ; BOUSQUET, J</creator><creatorcontrib>DEMOLY, P ; MALY, F. E ; MAUTINO, G ; GRAD, S ; GOUGAT, C ; SAHLA, H ; GODARD, P ; BOUSQUET, J</creatorcontrib><description>Background
Vascular permeability/vascular endothelial growth factor (VEGF) is a multifunctional cytokine which plays a role in chronic inflammation and angiogenesis. Its expression in bronchoalveolar lavage (BAL) has not been determined although VEGF may be relevant to the pathophysiology of asthma in which oedema is an important feature.
Methods
We studied VEGF, albumin and IgA immunoreactive levels in the BAL fluids obtained from 27 chronic stable asthmatics, nine untreated chronic bronchitis patients and 15 control subjects.
Results
BAL fluid levels of VEGF and VEGF normalized to IgA were not significantly different in any patient group. Both asthmatic steroid‐ and non‐steroid‐treated groups had significantly lower albumin levels in their BAL fluids explaining most of the 179% increased VEGF normalized to albumin ratios in non‐steroid treated asthmatics. Moreover, VEGF and albumin markers correlated in control subjects (r = 0.73, P = 0.006) and in chronic bronchitics (r = 0.75, P = 0.03, Spearman test), but not in asthmatics. VEGF was inversely correlated with asthma severity (GINA/NHLBI scores) in non‐steroid treated asthmatics (τ = − 0.52, P = 0.009, Kendall test).
Conclusions
Thus, the potential role of VEGF in asthma requires further studies on bronchial biopsies and induced sputum.</description><identifier>ISSN: 0954-7894</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1046/j.1365-2222.1999.00544.x</identifier><identifier>PMID: 10520060</identifier><language>eng</language><publisher>Oxford BSL: Blackwell Science Ltd</publisher><subject>Adult ; Aged ; asthma ; Asthma - blood ; Asthma - immunology ; BAL fluid ; Biological and medical sciences ; Bronchitis - immunology ; Bronchitis - pathology ; Bronchoalveolar Lavage Fluid - immunology ; Capillary Permeability - immunology ; chronic bronchitis ; Chronic Disease ; Chronic obstructive pulmonary disease, asthma ; Endothelial Growth Factors - blood ; Humans ; Immunoglobulin A - metabolism ; Lymphokines - blood ; Medical sciences ; Middle Aged ; Pneumology ; Serum Albumin - metabolism ; vascular endothelial growth factor ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors ; vascular inflammation ; VEGF</subject><ispartof>Clinical and experimental allergy, 1999-10, Vol.29 (10), p.1390-1394</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Oct 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4874-6b85748cf4ce91b914b331d5d45b47a004eb44f191601e614e838008c0e2d9623</citedby><cites>FETCH-LOGICAL-c4874-6b85748cf4ce91b914b331d5d45b47a004eb44f191601e614e838008c0e2d9623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2222.1999.00544.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2222.1999.00544.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1963919$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10520060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DEMOLY, P</creatorcontrib><creatorcontrib>MALY, F. E</creatorcontrib><creatorcontrib>MAUTINO, G</creatorcontrib><creatorcontrib>GRAD, S</creatorcontrib><creatorcontrib>GOUGAT, C</creatorcontrib><creatorcontrib>SAHLA, H</creatorcontrib><creatorcontrib>GODARD, P</creatorcontrib><creatorcontrib>BOUSQUET, J</creatorcontrib><title>VEGF levels in asthmatic airways do not correlate with plasma extravasation</title><title>Clinical and experimental allergy</title><addtitle>Clinical & Experimental Allergy</addtitle><description>Background
Vascular permeability/vascular endothelial growth factor (VEGF) is a multifunctional cytokine which plays a role in chronic inflammation and angiogenesis. Its expression in bronchoalveolar lavage (BAL) has not been determined although VEGF may be relevant to the pathophysiology of asthma in which oedema is an important feature.
Methods
We studied VEGF, albumin and IgA immunoreactive levels in the BAL fluids obtained from 27 chronic stable asthmatics, nine untreated chronic bronchitis patients and 15 control subjects.
Results
BAL fluid levels of VEGF and VEGF normalized to IgA were not significantly different in any patient group. Both asthmatic steroid‐ and non‐steroid‐treated groups had significantly lower albumin levels in their BAL fluids explaining most of the 179% increased VEGF normalized to albumin ratios in non‐steroid treated asthmatics. Moreover, VEGF and albumin markers correlated in control subjects (r = 0.73, P = 0.006) and in chronic bronchitics (r = 0.75, P = 0.03, Spearman test), but not in asthmatics. VEGF was inversely correlated with asthma severity (GINA/NHLBI scores) in non‐steroid treated asthmatics (τ = − 0.52, P = 0.009, Kendall test).
Conclusions
Thus, the potential role of VEGF in asthma requires further studies on bronchial biopsies and induced sputum.</description><subject>Adult</subject><subject>Aged</subject><subject>asthma</subject><subject>Asthma - blood</subject><subject>Asthma - immunology</subject><subject>BAL fluid</subject><subject>Biological and medical sciences</subject><subject>Bronchitis - immunology</subject><subject>Bronchitis - pathology</subject><subject>Bronchoalveolar Lavage Fluid - immunology</subject><subject>Capillary Permeability - immunology</subject><subject>chronic bronchitis</subject><subject>Chronic Disease</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Endothelial Growth Factors - blood</subject><subject>Humans</subject><subject>Immunoglobulin A - metabolism</subject><subject>Lymphokines - blood</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pneumology</subject><subject>Serum Albumin - metabolism</subject><subject>vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A</subject><subject>Vascular Endothelial Growth Factors</subject><subject>vascular inflammation</subject><subject>VEGF</subject><issn>0954-7894</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1v0zAUQC0EYmXwF5CFEG8J1_GNY0u8jKrrJiYQErBHy3EcLSUfnZ2u7b_HIdVAPOEXW_I519YhhDJIGaB4v0kZF3mSxZUypVQKkCOmhydk8XjxlCxA5ZgUUuEZeRHCBgB4ruRzcsYgzwAELMinH6v1JW3dg2sDbXpqwnjXmbGx1DR-b46BVgPth5HawXvXmtHRfTPe0W1rQmeoO4zePJgQjaF_SZ7Vpg3u1Wk_J98vV9-WV8nNl_X18uImsSgLTEQp8wKlrdE6xUrFsOScVXmFeYmFAUBXItZMMQHMCYZOcgkgLbisUiLj5-TdPHfrh_udC6PummBd25reDbugC5AZZAVE8M0_4GbY-T7-TcdqUnLBp2lyhqwfQvCu1lvfdMYfNQM91dYbPUXVU9TJU_p3bX2I6uvT_F3Zueovcc4bgbcnwARr2tqb3jbhD6cEV0xF7MOM7ZvWHf_7fb1cXcRD1JNZb8LoDo-68T-1KHiR69vPa42IH1lx-1Wv-S-Bz6ce</recordid><startdate>199910</startdate><enddate>199910</enddate><creator>DEMOLY, P</creator><creator>MALY, F. E</creator><creator>MAUTINO, G</creator><creator>GRAD, S</creator><creator>GOUGAT, C</creator><creator>SAHLA, H</creator><creator>GODARD, P</creator><creator>BOUSQUET, J</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>199910</creationdate><title>VEGF levels in asthmatic airways do not correlate with plasma extravasation</title><author>DEMOLY, P ; MALY, F. E ; MAUTINO, G ; GRAD, S ; GOUGAT, C ; SAHLA, H ; GODARD, P ; BOUSQUET, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4874-6b85748cf4ce91b914b331d5d45b47a004eb44f191601e614e838008c0e2d9623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Aged</topic><topic>asthma</topic><topic>Asthma - blood</topic><topic>Asthma - immunology</topic><topic>BAL fluid</topic><topic>Biological and medical sciences</topic><topic>Bronchitis - immunology</topic><topic>Bronchitis - pathology</topic><topic>Bronchoalveolar Lavage Fluid - immunology</topic><topic>Capillary Permeability - immunology</topic><topic>chronic bronchitis</topic><topic>Chronic Disease</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Endothelial Growth Factors - blood</topic><topic>Humans</topic><topic>Immunoglobulin A - metabolism</topic><topic>Lymphokines - blood</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pneumology</topic><topic>Serum Albumin - metabolism</topic><topic>vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A</topic><topic>Vascular Endothelial Growth Factors</topic><topic>vascular inflammation</topic><topic>VEGF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DEMOLY, P</creatorcontrib><creatorcontrib>MALY, F. E</creatorcontrib><creatorcontrib>MAUTINO, G</creatorcontrib><creatorcontrib>GRAD, S</creatorcontrib><creatorcontrib>GOUGAT, C</creatorcontrib><creatorcontrib>SAHLA, H</creatorcontrib><creatorcontrib>GODARD, P</creatorcontrib><creatorcontrib>BOUSQUET, J</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DEMOLY, P</au><au>MALY, F. E</au><au>MAUTINO, G</au><au>GRAD, S</au><au>GOUGAT, C</au><au>SAHLA, H</au><au>GODARD, P</au><au>BOUSQUET, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>VEGF levels in asthmatic airways do not correlate with plasma extravasation</atitle><jtitle>Clinical and experimental allergy</jtitle><addtitle>Clinical & Experimental Allergy</addtitle><date>1999-10</date><risdate>1999</risdate><volume>29</volume><issue>10</issue><spage>1390</spage><epage>1394</epage><pages>1390-1394</pages><issn>0954-7894</issn><eissn>1365-2222</eissn><abstract>Background
Vascular permeability/vascular endothelial growth factor (VEGF) is a multifunctional cytokine which plays a role in chronic inflammation and angiogenesis. Its expression in bronchoalveolar lavage (BAL) has not been determined although VEGF may be relevant to the pathophysiology of asthma in which oedema is an important feature.
Methods
We studied VEGF, albumin and IgA immunoreactive levels in the BAL fluids obtained from 27 chronic stable asthmatics, nine untreated chronic bronchitis patients and 15 control subjects.
Results
BAL fluid levels of VEGF and VEGF normalized to IgA were not significantly different in any patient group. Both asthmatic steroid‐ and non‐steroid‐treated groups had significantly lower albumin levels in their BAL fluids explaining most of the 179% increased VEGF normalized to albumin ratios in non‐steroid treated asthmatics. Moreover, VEGF and albumin markers correlated in control subjects (r = 0.73, P = 0.006) and in chronic bronchitics (r = 0.75, P = 0.03, Spearman test), but not in asthmatics. VEGF was inversely correlated with asthma severity (GINA/NHLBI scores) in non‐steroid treated asthmatics (τ = − 0.52, P = 0.009, Kendall test).
Conclusions
Thus, the potential role of VEGF in asthma requires further studies on bronchial biopsies and induced sputum.</abstract><cop>Oxford BSL</cop><pub>Blackwell Science Ltd</pub><pmid>10520060</pmid><doi>10.1046/j.1365-2222.1999.00544.x</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-7894 |
| ispartof | Clinical and experimental allergy, 1999-10, Vol.29 (10), p.1390-1394 |
| issn | 0954-7894 1365-2222 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70820270 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Aged asthma Asthma - blood Asthma - immunology BAL fluid Biological and medical sciences Bronchitis - immunology Bronchitis - pathology Bronchoalveolar Lavage Fluid - immunology Capillary Permeability - immunology chronic bronchitis Chronic Disease Chronic obstructive pulmonary disease, asthma Endothelial Growth Factors - blood Humans Immunoglobulin A - metabolism Lymphokines - blood Medical sciences Middle Aged Pneumology Serum Albumin - metabolism vascular endothelial growth factor Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors vascular inflammation VEGF |
| title | VEGF levels in asthmatic airways do not correlate with plasma extravasation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T11%3A14%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=VEGF%20levels%20in%20asthmatic%20airways%20do%20not%20correlate%20with%20plasma%20extravasation&rft.jtitle=Clinical%20and%20experimental%20allergy&rft.au=DEMOLY,%20P&rft.date=1999-10&rft.volume=29&rft.issue=10&rft.spage=1390&rft.epage=1394&rft.pages=1390-1394&rft.issn=0954-7894&rft.eissn=1365-2222&rft_id=info:doi/10.1046/j.1365-2222.1999.00544.x&rft_dat=%3Cproquest_cross%3E70820270%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=199883632&rft_id=info:pmid/10520060&rfr_iscdi=true |