In Vivo Detection of Intervertebral Disk Injury Using a Radiolabeled Monoclonal Antibody Against Keratan Sulfate

In the intervertebral disk, proteoglycans form the major part of the extracellular matrix, surrounding chondrocytelike disk cells. Keratan sulfate is a major constituent of proteoglycans. We have radioiodinated a monoclonal antibody raised against keratan sulfate. This antibody was injected into rat...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2001-03, Vol.42 (3), p.476-482
Hauptverfasser:	Kairemo, Kalevi J.A, Lappalainen, Anu K, Kaapa, Eeva, Laitinen, Outi M, Hyytinen, Timo, Karonen, Sirkka-Liisa, Gronblad, Mats
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacokinetics Biological and medical sciences Contrast media. Radiopharmaceuticals Intervertebral Disc - diagnostic imaging Intervertebral Disc - injuries Investigative techniques, diagnostic techniques (general aspects) Iodine Radioisotopes - pharmacokinetics Keratan Sulfate - immunology Male Medical sciences Osteoarticular system. Muscles Pharmacology. Drug treatments Radioimmunodetection Radionuclide investigations Rats Rats, Wistar Tissue Distribution
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