Calcitonin reverts pertussis toxin blockade of the opioid analgesia in mice

The aim of this paper is to study the influence of salmon calcitonin (SCT) on opioid analgesia when opioid transduction pathways are functionally uncoupled from G i/o proteins by treatment with pertussis toxin (PTX). The antinociceptive effect of morphine and three selective opioid agonists, [D–Ala...

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Veröffentlicht in:	Neuroscience letters 1999-10, Vol.273 (3), p.175-178
Hauptverfasser:	Goicoechea, Carlos, Ormazábal, M.Jesús, Abalo, Raquel, Alfaro, M.José, Martı́n, M.Isabel
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Analgesics - pharmacology Analgesics, Opioid Animals Biological and medical sciences Bordetella pertussis Calcitonin Calcitonin - pharmacology Enkephalin, Ala-MePhe-Gly Fundamental and applied biological sciences. Psychology GTP-Binding Proteins - drug effects Male Mice Morphine Opioids Pain - drug therapy Pertussis Toxin Receptors, Opioid - drug effects Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Tail Flick Uncoupling Agents - pharmacology Vertebrates: nervous system and sense organs Virulence Factors, Bordetella - antagonists & inhibitors
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