Calcitonin reverts pertussis toxin blockade of the opioid analgesia in mice
The aim of this paper is to study the influence of salmon calcitonin (SCT) on opioid analgesia when opioid transduction pathways are functionally uncoupled from G i/o proteins by treatment with pertussis toxin (PTX). The antinociceptive effect of morphine and three selective opioid agonists, [D–Ala...
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| Veröffentlicht in: | Neuroscience letters 1999-10, Vol.273 (3), p.175-178 |
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| creator | Goicoechea, Carlos Ormazábal, M.Jesús Abalo, Raquel Alfaro, M.José Martı́n, M.Isabel |
| description | The aim of this paper is to study the influence of salmon calcitonin (SCT) on opioid analgesia when opioid transduction pathways are functionally uncoupled from G
i/o proteins by treatment with pertussis toxin (PTX). The antinociceptive effect of morphine and three selective opioid agonists, [D–Ala
2,N–Me–Phe
2,Gly
5–ol]enkephalin (DAMGO) (OP
3-μ receptor agonist), [D–Pen
2,5]-enkephalin (OP
1-δ receptor agonist) and trans-(±)-3,4-dichloro-
N-methyl-N-[2–1(–pyrrolidinyl)cyclohexyl]-benzene-acetamide methane sulfonate (U-50, 488H) (OP
1-κreceptor agonist) was evaluated, using the tail flick test, in mice treated with PTX or with PTX and SCT. PTX blocked the antinociceptive effect of the opioids, being the antinociception similar in control animals and in mice treated with PTX and SCT. Thus, SCT prevents the effect of the blockade of G
i/o-proteins. From this it could be suggested that calcitonin activates alternative antinociceptive mechanisms that are not dependent on G
i/o-proteins. |
| doi_str_mv | 10.1016/S0304-3940(99)00640-0 |
| format | Article |
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i/o proteins by treatment with pertussis toxin (PTX). The antinociceptive effect of morphine and three selective opioid agonists, [D–Ala
2,N–Me–Phe
2,Gly
5–ol]enkephalin (DAMGO) (OP
3-μ receptor agonist), [D–Pen
2,5]-enkephalin (OP
1-δ receptor agonist) and trans-(±)-3,4-dichloro-
N-methyl-N-[2–1(–pyrrolidinyl)cyclohexyl]-benzene-acetamide methane sulfonate (U-50, 488H) (OP
1-κreceptor agonist) was evaluated, using the tail flick test, in mice treated with PTX or with PTX and SCT. PTX blocked the antinociceptive effect of the opioids, being the antinociception similar in control animals and in mice treated with PTX and SCT. Thus, SCT prevents the effect of the blockade of G
i/o-proteins. From this it could be suggested that calcitonin activates alternative antinociceptive mechanisms that are not dependent on G
i/o-proteins.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(99)00640-0</identifier><identifier>PMID: 10515187</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Analgesia ; Analgesics - pharmacology ; Analgesics, Opioid ; Animals ; Biological and medical sciences ; Bordetella pertussis ; Calcitonin ; Calcitonin - pharmacology ; Enkephalin, Ala-MePhe-Gly ; Fundamental and applied biological sciences. Psychology ; GTP-Binding Proteins - drug effects ; Male ; Mice ; Morphine ; Opioids ; Pain - drug therapy ; Pertussis Toxin ; Receptors, Opioid - drug effects ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Tail Flick ; Uncoupling Agents - pharmacology ; Vertebrates: nervous system and sense organs ; Virulence Factors, Bordetella - antagonists & inhibitors</subject><ispartof>Neuroscience letters, 1999-10, Vol.273 (3), p.175-178</ispartof><rights>1999 Elsevier Science Ireland Ltd</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-3b846852f0f789863903d3bd4a7db8e5fb7647c7dfdc13bfc23342d80bae4bf23</citedby><cites>FETCH-LOGICAL-c421t-3b846852f0f789863903d3bd4a7db8e5fb7647c7dfdc13bfc23342d80bae4bf23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394099006400$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1963305$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10515187$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goicoechea, Carlos</creatorcontrib><creatorcontrib>Ormazábal, M.Jesús</creatorcontrib><creatorcontrib>Abalo, Raquel</creatorcontrib><creatorcontrib>Alfaro, M.José</creatorcontrib><creatorcontrib>Martı́n, M.Isabel</creatorcontrib><title>Calcitonin reverts pertussis toxin blockade of the opioid analgesia in mice</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>The aim of this paper is to study the influence of salmon calcitonin (SCT) on opioid analgesia when opioid transduction pathways are functionally uncoupled from G
i/o proteins by treatment with pertussis toxin (PTX). The antinociceptive effect of morphine and three selective opioid agonists, [D–Ala
2,N–Me–Phe
2,Gly
5–ol]enkephalin (DAMGO) (OP
3-μ receptor agonist), [D–Pen
2,5]-enkephalin (OP
1-δ receptor agonist) and trans-(±)-3,4-dichloro-
N-methyl-N-[2–1(–pyrrolidinyl)cyclohexyl]-benzene-acetamide methane sulfonate (U-50, 488H) (OP
1-κreceptor agonist) was evaluated, using the tail flick test, in mice treated with PTX or with PTX and SCT. PTX blocked the antinociceptive effect of the opioids, being the antinociception similar in control animals and in mice treated with PTX and SCT. Thus, SCT prevents the effect of the blockade of G
i/o-proteins. From this it could be suggested that calcitonin activates alternative antinociceptive mechanisms that are not dependent on G
i/o-proteins.</description><subject>Analgesia</subject><subject>Analgesics - pharmacology</subject><subject>Analgesics, Opioid</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bordetella pertussis</subject><subject>Calcitonin</subject><subject>Calcitonin - pharmacology</subject><subject>Enkephalin, Ala-MePhe-Gly</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GTP-Binding Proteins - drug effects</subject><subject>Male</subject><subject>Mice</subject><subject>Morphine</subject><subject>Opioids</subject><subject>Pain - drug therapy</subject><subject>Pertussis Toxin</subject><subject>Receptors, Opioid - drug effects</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Tail Flick</subject><subject>Uncoupling Agents - pharmacology</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Virulence Factors, Bordetella - antagonists & inhibitors</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1P3DAQBmCrApUF-hNa5YBQewgdx04cnxBalYJA6qH0bPljXFyy8WJnEfz7etkVcOPisUbPjK2XkM8UTijQ7vtvYMBrJjl8lfIbQMehhg9kRnvR1EKKZofMXsge2c_5HwC0tOUfyR5dX4qckau5HmyY4hjGKuEDpilXy3Kucg65muJj6Zsh2jvtsIq-mm5LWYYYXKVHPfzFHHRVzCJYPCS7Xg8ZP23rAflz_uNmflFf__p5OT-7ri1v6FQz0_OubxsPXvSy75gE5phxXAtnemy9ER0XVjjvLGXG24Yx3rgejEZufMMOyPFm7zLF-xXmSS1CtjgMesS4ykpAT2Un6buQCi5azqHAdgNtijkn9GqZwkKnJ0VBreNWz3GrdZZKSvUct1rPfdk-sDILdG-mNvkWcLQFOls9-KRHG_Krkx1j0BZ2umFYYnsImFS2AUeLLiS0k3IxvPOT_7FNm9o</recordid><startdate>19991008</startdate><enddate>19991008</enddate><creator>Goicoechea, Carlos</creator><creator>Ormazábal, M.Jesús</creator><creator>Abalo, Raquel</creator><creator>Alfaro, M.José</creator><creator>Martı́n, M.Isabel</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19991008</creationdate><title>Calcitonin reverts pertussis toxin blockade of the opioid analgesia in mice</title><author>Goicoechea, Carlos ; Ormazábal, M.Jesús ; Abalo, Raquel ; Alfaro, M.José ; Martı́n, M.Isabel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-3b846852f0f789863903d3bd4a7db8e5fb7647c7dfdc13bfc23342d80bae4bf23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Analgesia</topic><topic>Analgesics - pharmacology</topic><topic>Analgesics, Opioid</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bordetella pertussis</topic><topic>Calcitonin</topic><topic>Calcitonin - pharmacology</topic><topic>Enkephalin, Ala-MePhe-Gly</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GTP-Binding Proteins - drug effects</topic><topic>Male</topic><topic>Mice</topic><topic>Morphine</topic><topic>Opioids</topic><topic>Pain - drug therapy</topic><topic>Pertussis Toxin</topic><topic>Receptors, Opioid - drug effects</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Tail Flick</topic><topic>Uncoupling Agents - pharmacology</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Virulence Factors, Bordetella - antagonists & inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goicoechea, Carlos</creatorcontrib><creatorcontrib>Ormazábal, M.Jesús</creatorcontrib><creatorcontrib>Abalo, Raquel</creatorcontrib><creatorcontrib>Alfaro, M.José</creatorcontrib><creatorcontrib>Martı́n, M.Isabel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goicoechea, Carlos</au><au>Ormazábal, M.Jesús</au><au>Abalo, Raquel</au><au>Alfaro, M.José</au><au>Martı́n, M.Isabel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Calcitonin reverts pertussis toxin blockade of the opioid analgesia in mice</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1999-10-08</date><risdate>1999</risdate><volume>273</volume><issue>3</issue><spage>175</spage><epage>178</epage><pages>175-178</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The aim of this paper is to study the influence of salmon calcitonin (SCT) on opioid analgesia when opioid transduction pathways are functionally uncoupled from G
i/o proteins by treatment with pertussis toxin (PTX). The antinociceptive effect of morphine and three selective opioid agonists, [D–Ala
2,N–Me–Phe
2,Gly
5–ol]enkephalin (DAMGO) (OP
3-μ receptor agonist), [D–Pen
2,5]-enkephalin (OP
1-δ receptor agonist) and trans-(±)-3,4-dichloro-
N-methyl-N-[2–1(–pyrrolidinyl)cyclohexyl]-benzene-acetamide methane sulfonate (U-50, 488H) (OP
1-κreceptor agonist) was evaluated, using the tail flick test, in mice treated with PTX or with PTX and SCT. PTX blocked the antinociceptive effect of the opioids, being the antinociception similar in control animals and in mice treated with PTX and SCT. Thus, SCT prevents the effect of the blockade of G
i/o-proteins. From this it could be suggested that calcitonin activates alternative antinociceptive mechanisms that are not dependent on G
i/o-proteins.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10515187</pmid><doi>10.1016/S0304-3940(99)00640-0</doi><tpages>4</tpages></addata></record> |
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| issn | 0304-3940 1872-7972 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Analgesia Analgesics - pharmacology Analgesics, Opioid Animals Biological and medical sciences Bordetella pertussis Calcitonin Calcitonin - pharmacology Enkephalin, Ala-MePhe-Gly Fundamental and applied biological sciences. Psychology GTP-Binding Proteins - drug effects Male Mice Morphine Opioids Pain - drug therapy Pertussis Toxin Receptors, Opioid - drug effects Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Tail Flick Uncoupling Agents - pharmacology Vertebrates: nervous system and sense organs Virulence Factors, Bordetella - antagonists & inhibitors |
| title | Calcitonin reverts pertussis toxin blockade of the opioid analgesia in mice |
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