Antiviral B Cell Memory in the Absence of Mature Follicular Dendritic Cell Networks and Classical Germinal Centers in TNFR1-/- Mice

TNFR1-/- mice have been shown to lack networks of mature follicular dendritic cells (FDCs) and they do not form germinal centers. With nonreplicating Ags, IgG titers were inefficiently induced and not maintained. In this study, the neutralizing Ab response and the establishment of B cell memory in T...

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Veröffentlicht in:	The Journal of immunology (1950) 2000-01, Vol.164 (2), p.768-778
Hauptverfasser:	Karrer, U, Lopez-Macias, C, Oxenius, A, Odermatt, B, Bachmann, M. F, Kalinke, U, Bluethmann, H, Hengartner, H, Zinkernagel, R. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Antibody Affinity Antigens, CD - genetics Antigens, CD - metabolism Antigens, Viral - immunology B-Lymphocytes - immunology B-Lymphocytes - metabolism B-Lymphocytes - pathology B-Lymphocytes - virology Bone Marrow - immunology Bone Marrow - metabolism Bone Marrow - pathology Cell Communication - genetics Cell Communication - immunology Cell Differentiation - genetics Cell Differentiation - immunology Cell Line Cricetinae Dendritic Cells, Follicular - immunology Dendritic Cells, Follicular - metabolism Dendritic Cells, Follicular - pathology Freund's Adjuvant - administration & dosage Freund's Adjuvant - immunology Immunoglobulin Class Switching - genetics Immunoglobulin G - biosynthesis Immunoglobulin G - blood Immunoglobulin M - biosynthesis Immunologic Memory - genetics Injections, Subcutaneous Kinetics Lymph Nodes - immunology Lymph Nodes - metabolism Lymph Nodes - pathology Mesentery Mice Mice, Inbred C57BL Mice, Knockout Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor - metabolism Receptors, Tumor Necrosis Factor, Type I Spleen - immunology Spleen - metabolism Spleen - pathology Vesicular stomatitis Indiana virus - immunology Vesicular stomatitis Indiana virus - physiology Viral Vaccines - administration & dosage Viral Vaccines - immunology Virus Replication - genetics Virus Replication - immunology
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