Transcriptional Regulation of the Leptin Promoter by Insulin-Stimulated Glucose Metabolism in 3T3-L1 Adipocytes

Insulin-stimulated glucose metabolism plays a key role in the regulation of leptin mRNA expression and protein secretion. However, it is not known whether stimulation of leptin production by glucose metabolism is regulated at the level of promoter activation or at a step distal to the promoter. Ther...

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Veröffentlicht in:	Biochemical and biophysical research communications 2001-05, Vol.283 (3), p.544-548
Hauptverfasser:	Moreno-Aliaga, María J., Stanhope, Kimber L., Havel, Peter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-deoxy-D-glucose 3T3 Cells Adipocytes - drug effects Adipocytes - metabolism Animals Deoxyglucose - pharmacology Glucose - metabolism insulin Insulin - pharmacology Leptin - genetics leptin promoter Mice Promoter Regions, Genetic Transcriptional Activation - drug effects
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