Hypertrophic osteoarthropathy can indicate recurrence of Whipple's disease
We report the case of a patient with Whipple's disease (WD) who developed hypertrophic osteoarthropathy (HOA) characterized by digital clubbing, periostosis of the tubular bones, and polysynovitis. The HOA disclosed the recurrence of the patient's WD, since polymerase chain reaction (PCR)...
Gespeichert in:
| Veröffentlicht in: | Arthritis and rheumatism 1999-09, Vol.42 (9), p.2002-2006 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2006 |
|---|---|
| container_issue | 9 |
| container_start_page | 2002 |
| container_title | Arthritis and rheumatism |
| container_volume | 42 |
| creator | Marie, Isabelle Levesque, Herv´e Levade, Marc‐Henri Cailleux, Nicole Lecomte, Fŕed´eric François, Arnaud M´etayer, Josette Lerebours, Eric Courtois, Hubert |
| description | We report the case of a patient with Whipple's disease (WD) who developed hypertrophic osteoarthropathy (HOA) characterized by digital clubbing, periostosis of the tubular bones, and polysynovitis. The HOA disclosed the recurrence of the patient's WD, since polymerase chain reaction (PCR) analysis clearly demonstrated the presence of Tropheryma whippelii in the synovial fluid from the patient's left knee. Initiation of appropriate antibiotic therapy resulted in complete healing of all clinical rheumatologic manifestations within 2 months and in disappearance of radiographic bone changes at 7‐month followup. We suggest that HOA be included within the spectrum of rheumatologic manifestations of WD, and that an evaluation for WD should be considered in patients, especially middle‐aged men, presenting with HOA even without gastrointestinal symptoms. PCR analysis may be useful in accurate diagnosis and management of early WD with unusual clinical manifestations, and may contribute to decreased morbidity and mortality. |
| doi_str_mv | 10.1002/1529-0131(199909)42:9<2002::AID-ANR29>3.0.CO;2-C |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70818096</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70818096</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4579-c30e7b8f14325afb21c7a6234cdc9aef181289474105a28b405abdcb49e0fdb93</originalsourceid><addsrcrecordid>eNqVkE1v1DAQhi1ERbeFv4ByQFAOWcYf2cTbqtIqUFpUsagCcRw5zkRrlE2CnRXaf4-XrIADF06jsR_PvH4YKzjMOYB4wzOhU-CSX3CtNejXSiz1lYhXy-Xq7m26-vgg9LWcw7xcX4q0fMRmv588ZjMAUKnMND9lZyF8i62QmXzCTjlkXBa8mLEPt_uB_Oj7YeNs0oeReuPHTezNuNkn1nSJ62pnzUiJJ7vznjpLSd8kXzduGFp6FZLaBTKBnrKTxrSBnh3rOfty8-5zeZver9_flav71Kos16mVQHlVNFxJkZmmEtzmZiGksrXVhhpecFFolasY0oiiUrFUta2UJmjqSstz9nKaO_j--47CiFsXLLWt6ajfBcwh_gz0IoKfJtD6PgRPDQ7ebY3fIwc8-MWDLDzIwskvKoEaD34Ro1_85RclApZrFFjGkc-Pu3fVluq_Bk5CI_DiCJhgTdt401kX_nA6XywyiNjDhP1wLe3_J9e_Yk0H8icrKqAA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70818096</pqid></control><display><type>article</type><title>Hypertrophic osteoarthropathy can indicate recurrence of Whipple's disease</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Marie, Isabelle ; Levesque, Herv´e ; Levade, Marc‐Henri ; Cailleux, Nicole ; Lecomte, Fŕed´eric ; François, Arnaud ; M´etayer, Josette ; Lerebours, Eric ; Courtois, Hubert</creator><creatorcontrib>Marie, Isabelle ; Levesque, Herv´e ; Levade, Marc‐Henri ; Cailleux, Nicole ; Lecomte, Fŕed´eric ; François, Arnaud ; M´etayer, Josette ; Lerebours, Eric ; Courtois, Hubert</creatorcontrib><description>We report the case of a patient with Whipple's disease (WD) who developed hypertrophic osteoarthropathy (HOA) characterized by digital clubbing, periostosis of the tubular bones, and polysynovitis. The HOA disclosed the recurrence of the patient's WD, since polymerase chain reaction (PCR) analysis clearly demonstrated the presence of Tropheryma whippelii in the synovial fluid from the patient's left knee. Initiation of appropriate antibiotic therapy resulted in complete healing of all clinical rheumatologic manifestations within 2 months and in disappearance of radiographic bone changes at 7‐month followup. We suggest that HOA be included within the spectrum of rheumatologic manifestations of WD, and that an evaluation for WD should be considered in patients, especially middle‐aged men, presenting with HOA even without gastrointestinal symptoms. PCR analysis may be useful in accurate diagnosis and management of early WD with unusual clinical manifestations, and may contribute to decreased morbidity and mortality.</description><identifier>ISSN: 0004-3591</identifier><identifier>EISSN: 1529-0131</identifier><identifier>DOI: 10.1002/1529-0131(199909)42:9<2002::AID-ANR29>3.0.CO;2-C</identifier><identifier>PMID: 10513818</identifier><identifier>CODEN: ARHEAW</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Anti-Bacterial Agents - therapeutic use ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Biological and medical sciences ; Biopsy ; Bone and Bones - diagnostic imaging ; Duodenum - pathology ; Human bacterial diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Osteoarthropathy, Primary Hypertrophic - complications ; Osteoarthropathy, Primary Hypertrophic - diagnostic imaging ; Osteoarthropathy, Primary Hypertrophic - drug therapy ; Radiography ; Whipple Disease - complications ; Whipple Disease - pathology</subject><ispartof>Arthritis and rheumatism, 1999-09, Vol.42 (9), p.2002-2006</ispartof><rights>Copyright © 1999 by the American College of Rheumatology</rights><rights>1999 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4579-c30e7b8f14325afb21c7a6234cdc9aef181289474105a28b405abdcb49e0fdb93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F1529-0131%28199909%2942%3A9%3C2002%3A%3AAID-ANR29%3E3.0.CO%3B2-C$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F1529-0131%28199909%2942%3A9%3C2002%3A%3AAID-ANR29%3E3.0.CO%3B2-C$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1976650$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10513818$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marie, Isabelle</creatorcontrib><creatorcontrib>Levesque, Herv´e</creatorcontrib><creatorcontrib>Levade, Marc‐Henri</creatorcontrib><creatorcontrib>Cailleux, Nicole</creatorcontrib><creatorcontrib>Lecomte, Fŕed´eric</creatorcontrib><creatorcontrib>François, Arnaud</creatorcontrib><creatorcontrib>M´etayer, Josette</creatorcontrib><creatorcontrib>Lerebours, Eric</creatorcontrib><creatorcontrib>Courtois, Hubert</creatorcontrib><title>Hypertrophic osteoarthropathy can indicate recurrence of Whipple's disease</title><title>Arthritis and rheumatism</title><addtitle>Arthritis Rheum</addtitle><description>We report the case of a patient with Whipple's disease (WD) who developed hypertrophic osteoarthropathy (HOA) characterized by digital clubbing, periostosis of the tubular bones, and polysynovitis. The HOA disclosed the recurrence of the patient's WD, since polymerase chain reaction (PCR) analysis clearly demonstrated the presence of Tropheryma whippelii in the synovial fluid from the patient's left knee. Initiation of appropriate antibiotic therapy resulted in complete healing of all clinical rheumatologic manifestations within 2 months and in disappearance of radiographic bone changes at 7‐month followup. We suggest that HOA be included within the spectrum of rheumatologic manifestations of WD, and that an evaluation for WD should be considered in patients, especially middle‐aged men, presenting with HOA even without gastrointestinal symptoms. PCR analysis may be useful in accurate diagnosis and management of early WD with unusual clinical manifestations, and may contribute to decreased morbidity and mortality.</description><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Bone and Bones - diagnostic imaging</subject><subject>Duodenum - pathology</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Osteoarthropathy, Primary Hypertrophic - complications</subject><subject>Osteoarthropathy, Primary Hypertrophic - diagnostic imaging</subject><subject>Osteoarthropathy, Primary Hypertrophic - drug therapy</subject><subject>Radiography</subject><subject>Whipple Disease - complications</subject><subject>Whipple Disease - pathology</subject><issn>0004-3591</issn><issn>1529-0131</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE1v1DAQhi1ERbeFv4ByQFAOWcYf2cTbqtIqUFpUsagCcRw5zkRrlE2CnRXaf4-XrIADF06jsR_PvH4YKzjMOYB4wzOhU-CSX3CtNejXSiz1lYhXy-Xq7m26-vgg9LWcw7xcX4q0fMRmv588ZjMAUKnMND9lZyF8i62QmXzCTjlkXBa8mLEPt_uB_Oj7YeNs0oeReuPHTezNuNkn1nSJ62pnzUiJJ7vznjpLSd8kXzduGFp6FZLaBTKBnrKTxrSBnh3rOfty8-5zeZver9_flav71Kos16mVQHlVNFxJkZmmEtzmZiGksrXVhhpecFFolasY0oiiUrFUta2UJmjqSstz9nKaO_j--47CiFsXLLWt6ajfBcwh_gz0IoKfJtD6PgRPDQ7ebY3fIwc8-MWDLDzIwskvKoEaD34Ro1_85RclApZrFFjGkc-Pu3fVluq_Bk5CI_DiCJhgTdt401kX_nA6XywyiNjDhP1wLe3_J9e_Yk0H8icrKqAA</recordid><startdate>199909</startdate><enddate>199909</enddate><creator>Marie, Isabelle</creator><creator>Levesque, Herv´e</creator><creator>Levade, Marc‐Henri</creator><creator>Cailleux, Nicole</creator><creator>Lecomte, Fŕed´eric</creator><creator>François, Arnaud</creator><creator>M´etayer, Josette</creator><creator>Lerebours, Eric</creator><creator>Courtois, Hubert</creator><general>John Wiley & Sons, Inc</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199909</creationdate><title>Hypertrophic osteoarthropathy can indicate recurrence of Whipple's disease</title><author>Marie, Isabelle ; Levesque, Herv´e ; Levade, Marc‐Henri ; Cailleux, Nicole ; Lecomte, Fŕed´eric ; François, Arnaud ; M´etayer, Josette ; Lerebours, Eric ; Courtois, Hubert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4579-c30e7b8f14325afb21c7a6234cdc9aef181289474105a28b405abdcb49e0fdb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the digestive system and abdomen</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Bone and Bones - diagnostic imaging</topic><topic>Duodenum - pathology</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Osteoarthropathy, Primary Hypertrophic - complications</topic><topic>Osteoarthropathy, Primary Hypertrophic - diagnostic imaging</topic><topic>Osteoarthropathy, Primary Hypertrophic - drug therapy</topic><topic>Radiography</topic><topic>Whipple Disease - complications</topic><topic>Whipple Disease - pathology</topic><toplevel>online_resources</toplevel><creatorcontrib>Marie, Isabelle</creatorcontrib><creatorcontrib>Levesque, Herv´e</creatorcontrib><creatorcontrib>Levade, Marc‐Henri</creatorcontrib><creatorcontrib>Cailleux, Nicole</creatorcontrib><creatorcontrib>Lecomte, Fŕed´eric</creatorcontrib><creatorcontrib>François, Arnaud</creatorcontrib><creatorcontrib>M´etayer, Josette</creatorcontrib><creatorcontrib>Lerebours, Eric</creatorcontrib><creatorcontrib>Courtois, Hubert</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marie, Isabelle</au><au>Levesque, Herv´e</au><au>Levade, Marc‐Henri</au><au>Cailleux, Nicole</au><au>Lecomte, Fŕed´eric</au><au>François, Arnaud</au><au>M´etayer, Josette</au><au>Lerebours, Eric</au><au>Courtois, Hubert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypertrophic osteoarthropathy can indicate recurrence of Whipple's disease</atitle><jtitle>Arthritis and rheumatism</jtitle><addtitle>Arthritis Rheum</addtitle><date>1999-09</date><risdate>1999</risdate><volume>42</volume><issue>9</issue><spage>2002</spage><epage>2006</epage><pages>2002-2006</pages><issn>0004-3591</issn><eissn>1529-0131</eissn><coden>ARHEAW</coden><abstract>We report the case of a patient with Whipple's disease (WD) who developed hypertrophic osteoarthropathy (HOA) characterized by digital clubbing, periostosis of the tubular bones, and polysynovitis. The HOA disclosed the recurrence of the patient's WD, since polymerase chain reaction (PCR) analysis clearly demonstrated the presence of Tropheryma whippelii in the synovial fluid from the patient's left knee. Initiation of appropriate antibiotic therapy resulted in complete healing of all clinical rheumatologic manifestations within 2 months and in disappearance of radiographic bone changes at 7‐month followup. We suggest that HOA be included within the spectrum of rheumatologic manifestations of WD, and that an evaluation for WD should be considered in patients, especially middle‐aged men, presenting with HOA even without gastrointestinal symptoms. PCR analysis may be useful in accurate diagnosis and management of early WD with unusual clinical manifestations, and may contribute to decreased morbidity and mortality.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>10513818</pmid><doi>10.1002/1529-0131(199909)42:9<2002::AID-ANR29>3.0.CO;2-C</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0004-3591 |
| ispartof | Arthritis and rheumatism, 1999-09, Vol.42 (9), p.2002-2006 |
| issn | 0004-3591 1529-0131 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70818096 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Anti-Bacterial Agents - therapeutic use Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Biopsy Bone and Bones - diagnostic imaging Duodenum - pathology Human bacterial diseases Humans Infectious diseases Male Medical sciences Middle Aged Osteoarthropathy, Primary Hypertrophic - complications Osteoarthropathy, Primary Hypertrophic - diagnostic imaging Osteoarthropathy, Primary Hypertrophic - drug therapy Radiography Whipple Disease - complications Whipple Disease - pathology |
| title | Hypertrophic osteoarthropathy can indicate recurrence of Whipple's disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T21%3A16%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hypertrophic%20osteoarthropathy%20can%20indicate%20recurrence%20of%20Whipple's%20disease&rft.jtitle=Arthritis%20and%20rheumatism&rft.au=Marie,%20Isabelle&rft.date=1999-09&rft.volume=42&rft.issue=9&rft.spage=2002&rft.epage=2006&rft.pages=2002-2006&rft.issn=0004-3591&rft.eissn=1529-0131&rft.coden=ARHEAW&rft_id=info:doi/10.1002/1529-0131(199909)42:9%3C2002::AID-ANR29%3E3.0.CO;2-C&rft_dat=%3Cproquest_cross%3E70818096%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70818096&rft_id=info:pmid/10513818&rfr_iscdi=true |