Expression of interleukin-15 in human endometrium and decidua
In human endometrium, cytokines and growth factors that vary periodically during the menstrual cycles have been suggested to play various roles in uterine function. In the present study, differential gene expression in human endometrium between the proliferative and the secretory phases was investig...
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| Veröffentlicht in: | Molecular human reproduction 2000-01, Vol.6 (1), p.75-80 |
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| container_title | Molecular human reproduction |
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| creator | Okada, Sonoko Okada, Hidetaka Sanezumi, Mayumi Nakajima, Tatsuya Yasuda, Katsuhiko Kanzaki, Hideharu |
| description | In human endometrium, cytokines and growth factors that vary periodically during the menstrual cycles have been suggested to play various roles in uterine function. In the present study, differential gene expression in human endometrium between the proliferative and the secretory phases was investigated by using a human cDNA expression array system. Human interleukin (IL)-15 was identified as an up-regulated transcription product during the secretory phase, in comparison with the proliferative phase, and therefore its expression in human uterus was examined by Northern blot analysis. In human endometrium, expression of IL-15 mRNA significantly increased during the secretory phase compared with the proliferative phase (P < 0.01). The most abundant expression of IL-15 mRNA during the menstrual cycle was observed in the midsecretory phase. In the first trimester pregnancy, the expression of IL-15 mRNA in the decidua was significantly higher than that in the chorionic villi (P < 0.01). By using an in-vitro decidualization with human endometrial stromal cells, it was demonstrated that the expression of IL-15 mRNA is up-regulated during progesterone-induced decidualization. These results suggest that IL-15 plays a role in uterine function during pregnancy, as well as during the menstrual cycle. |
| doi_str_mv | 10.1093/molehr/6.1.75 |
| format | Article |
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In the present study, differential gene expression in human endometrium between the proliferative and the secretory phases was investigated by using a human cDNA expression array system. Human interleukin (IL)-15 was identified as an up-regulated transcription product during the secretory phase, in comparison with the proliferative phase, and therefore its expression in human uterus was examined by Northern blot analysis. In human endometrium, expression of IL-15 mRNA significantly increased during the secretory phase compared with the proliferative phase (P < 0.01). The most abundant expression of IL-15 mRNA during the menstrual cycle was observed in the midsecretory phase. In the first trimester pregnancy, the expression of IL-15 mRNA in the decidua was significantly higher than that in the chorionic villi (P < 0.01). By using an in-vitro decidualization with human endometrial stromal cells, it was demonstrated that the expression of IL-15 mRNA is up-regulated during progesterone-induced decidualization. These results suggest that IL-15 plays a role in uterine function during pregnancy, as well as during the menstrual cycle.</description><identifier>ISSN: 1360-9947</identifier><identifier>ISSN: 1460-2407</identifier><identifier>EISSN: 1460-2407</identifier><identifier>DOI: 10.1093/molehr/6.1.75</identifier><identifier>PMID: 10611264</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adaptor Proteins, Signal Transducing ; Adult ; Biological and medical sciences ; Calcium-Binding Proteins - genetics ; Cells, Cultured ; chorion ; decidua ; Decidua - metabolism ; Decidua - pathology ; decidualization ; endometrium ; Endometrium - metabolism ; Endometrium - pathology ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; Hormone metabolism and regulation ; Humans ; IL-15 ; Interleukin-15 - biosynthesis ; Interleukin-15 - genetics ; Intracellular Signaling Peptides and Proteins ; Mammalian female genital system ; Middle Aged ; Phosphoproteins - genetics ; Pregnancy ; Vertebrates: reproduction</subject><ispartof>Molecular human reproduction, 2000-01, Vol.6 (1), p.75-80</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Jan 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-d0818a3913029747490f376b01879cd7764dec2653d226c597861aa4b438ffa23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1305964$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10611264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okada, Sonoko</creatorcontrib><creatorcontrib>Okada, Hidetaka</creatorcontrib><creatorcontrib>Sanezumi, Mayumi</creatorcontrib><creatorcontrib>Nakajima, Tatsuya</creatorcontrib><creatorcontrib>Yasuda, Katsuhiko</creatorcontrib><creatorcontrib>Kanzaki, Hideharu</creatorcontrib><title>Expression of interleukin-15 in human endometrium and decidua</title><title>Molecular human reproduction</title><addtitle>Mol. Hum. Reprod</addtitle><description>In human endometrium, cytokines and growth factors that vary periodically during the menstrual cycles have been suggested to play various roles in uterine function. In the present study, differential gene expression in human endometrium between the proliferative and the secretory phases was investigated by using a human cDNA expression array system. Human interleukin (IL)-15 was identified as an up-regulated transcription product during the secretory phase, in comparison with the proliferative phase, and therefore its expression in human uterus was examined by Northern blot analysis. In human endometrium, expression of IL-15 mRNA significantly increased during the secretory phase compared with the proliferative phase (P < 0.01). The most abundant expression of IL-15 mRNA during the menstrual cycle was observed in the midsecretory phase. In the first trimester pregnancy, the expression of IL-15 mRNA in the decidua was significantly higher than that in the chorionic villi (P < 0.01). By using an in-vitro decidualization with human endometrial stromal cells, it was demonstrated that the expression of IL-15 mRNA is up-regulated during progesterone-induced decidualization. These results suggest that IL-15 plays a role in uterine function during pregnancy, as well as during the menstrual cycle.</description><subject>Adaptor Proteins, Signal Transducing</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Calcium-Binding Proteins - genetics</subject><subject>Cells, Cultured</subject><subject>chorion</subject><subject>decidua</subject><subject>Decidua - metabolism</subject><subject>Decidua - pathology</subject><subject>decidualization</subject><subject>endometrium</subject><subject>Endometrium - metabolism</subject><subject>Endometrium - pathology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>Hormone metabolism and regulation</subject><subject>Humans</subject><subject>IL-15</subject><subject>Interleukin-15 - biosynthesis</subject><subject>Interleukin-15 - genetics</subject><subject>Intracellular Signaling Peptides and Proteins</subject><subject>Mammalian female genital system</subject><subject>Middle Aged</subject><subject>Phosphoproteins - genetics</subject><subject>Pregnancy</subject><subject>Vertebrates: reproduction</subject><issn>1360-9947</issn><issn>1460-2407</issn><issn>1460-2407</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0M1LHDEYBvAgFr_ao1cZRLzNmjdf7-TgQRZ124pS2kLpJWRnMhidyazJDNj_3sgurXjpKW_Ij-clDyGHQGdANT_rh87dxzM1gxnKLbIHQtGSCYrbeeZ51lrgLtlP6YFSQCarHbILVAEwJfbI-eXzKrqU_BCKoS18GF3s3PToQwkyX4v7qbehcKEZejdGP_WFDU3RuNo3k_1IPrS2S-7T5jwgP68uf8wX5c3d9ef5xU1ZS9Bj2dAKKss1cMo0ChSathzVkkKFum4QlciBTEneMKZqqbFSYK1YCl61rWX8gJyuc1dxeJpcGk3vU-26zgY3TMlgXoCa8f9CRoWQvJIZHr-DD8MUQ_6EYUwyoMhFRuUa1XFIKbrWrKLvbfxjgJrX9s26faMMGHwNPdqETsveNW_0uu4MTjbAptp2bbSh9umf41Rq9WavT6N7_vts46NRyFGaxa_fZnE7_zK_-vrdfOMvufiaUg</recordid><startdate>200001</startdate><enddate>200001</enddate><creator>Okada, Sonoko</creator><creator>Okada, Hidetaka</creator><creator>Sanezumi, Mayumi</creator><creator>Nakajima, Tatsuya</creator><creator>Yasuda, Katsuhiko</creator><creator>Kanzaki, Hideharu</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200001</creationdate><title>Expression of interleukin-15 in human endometrium and decidua</title><author>Okada, Sonoko ; Okada, Hidetaka ; Sanezumi, Mayumi ; Nakajima, Tatsuya ; Yasuda, Katsuhiko ; Kanzaki, Hideharu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-d0818a3913029747490f376b01879cd7764dec2653d226c597861aa4b438ffa23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adaptor Proteins, Signal Transducing</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Calcium-Binding Proteins - genetics</topic><topic>Cells, Cultured</topic><topic>chorion</topic><topic>decidua</topic><topic>Decidua - metabolism</topic><topic>Decidua - pathology</topic><topic>decidualization</topic><topic>endometrium</topic><topic>Endometrium - metabolism</topic><topic>Endometrium - pathology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>Hormone metabolism and regulation</topic><topic>Humans</topic><topic>IL-15</topic><topic>Interleukin-15 - biosynthesis</topic><topic>Interleukin-15 - genetics</topic><topic>Intracellular Signaling Peptides and Proteins</topic><topic>Mammalian female genital system</topic><topic>Middle Aged</topic><topic>Phosphoproteins - genetics</topic><topic>Pregnancy</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okada, Sonoko</creatorcontrib><creatorcontrib>Okada, Hidetaka</creatorcontrib><creatorcontrib>Sanezumi, Mayumi</creatorcontrib><creatorcontrib>Nakajima, Tatsuya</creatorcontrib><creatorcontrib>Yasuda, Katsuhiko</creatorcontrib><creatorcontrib>Kanzaki, Hideharu</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular human reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okada, Sonoko</au><au>Okada, Hidetaka</au><au>Sanezumi, Mayumi</au><au>Nakajima, Tatsuya</au><au>Yasuda, Katsuhiko</au><au>Kanzaki, Hideharu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of interleukin-15 in human endometrium and decidua</atitle><jtitle>Molecular human reproduction</jtitle><addtitle>Mol. Hum. Reprod</addtitle><date>2000-01</date><risdate>2000</risdate><volume>6</volume><issue>1</issue><spage>75</spage><epage>80</epage><pages>75-80</pages><issn>1360-9947</issn><issn>1460-2407</issn><eissn>1460-2407</eissn><abstract>In human endometrium, cytokines and growth factors that vary periodically during the menstrual cycles have been suggested to play various roles in uterine function. In the present study, differential gene expression in human endometrium between the proliferative and the secretory phases was investigated by using a human cDNA expression array system. Human interleukin (IL)-15 was identified as an up-regulated transcription product during the secretory phase, in comparison with the proliferative phase, and therefore its expression in human uterus was examined by Northern blot analysis. In human endometrium, expression of IL-15 mRNA significantly increased during the secretory phase compared with the proliferative phase (P < 0.01). The most abundant expression of IL-15 mRNA during the menstrual cycle was observed in the midsecretory phase. In the first trimester pregnancy, the expression of IL-15 mRNA in the decidua was significantly higher than that in the chorionic villi (P < 0.01). By using an in-vitro decidualization with human endometrial stromal cells, it was demonstrated that the expression of IL-15 mRNA is up-regulated during progesterone-induced decidualization. These results suggest that IL-15 plays a role in uterine function during pregnancy, as well as during the menstrual cycle.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>10611264</pmid><doi>10.1093/molehr/6.1.75</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptor Proteins, Signal Transducing Adult Biological and medical sciences Calcium-Binding Proteins - genetics Cells, Cultured chorion decidua Decidua - metabolism Decidua - pathology decidualization endometrium Endometrium - metabolism Endometrium - pathology Female Fundamental and applied biological sciences. Psychology Gene Expression Hormone metabolism and regulation Humans IL-15 Interleukin-15 - biosynthesis Interleukin-15 - genetics Intracellular Signaling Peptides and Proteins Mammalian female genital system Middle Aged Phosphoproteins - genetics Pregnancy Vertebrates: reproduction |
| title | Expression of interleukin-15 in human endometrium and decidua |
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