Identification of a novel member of the T1R family of putative taste receptors
In the gustatory system, the recognition of sugars, amino acids and bitter‐tasting compounds is the function of specialized G protein‐coupled receptors. Recently, two members of novel subfamily of G protein‐coupled receptors were proposed to function as taste receptors based on their specific expres...
Gespeichert in:
| Veröffentlicht in: | Journal of neurochemistry 2001-05, Vol.77 (3), p.896-903 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 903 |
|---|---|
| container_issue | 3 |
| container_start_page | 896 |
| container_title | Journal of neurochemistry |
| container_volume | 77 |
| creator | Sainz, Eduardo Korley, Julius N. Battey, James F. Sullivan, Susan L. |
| description | In the gustatory system, the recognition of sugars, amino acids and bitter‐tasting compounds is the function of specialized G protein‐coupled receptors. Recently, two members of novel subfamily of G protein‐coupled receptors were proposed to function as taste receptors based on their specific expression in taste receptor cells. Here, we report the identification of a third member, T1R3, of this family of receptors. T1R3 maps near the telomere of mouse chromosome 4 rendering it a candidate for the Sac locus, a primary determinant of sweet preference in mice. Consistent with its candidacy for the Sac locus, T1R3 displays taste receptor cell‐specific expression. In addition, taster and non‐taster strains of mouse harbor different alleles of T1R3. |
| doi_str_mv | 10.1046/j.1471-4159.2001.00292.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70817752</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70817752</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4912-203d2202efa77faad467a1a5e8b94dcf56f49a643c20057afdbfc929a9498cdd3</originalsourceid><addsrcrecordid>eNqNkE1P3DAQhi3UChbav1D5UPWW1OM4cXzgUK2gUCEqIThbs85YzSofi50F9t837q7a3uDk0etnPJ6HMQ4iB6Gqr-sclIZMQWlyKQTkQkgj85cjtvh78Y4t5lRmhVDyhJ3GuJ7BSlVwzE4AigIU1At2e93QMLW-dTi148BHz5EP4xN1vKd-RSEl0y_i93DHPfZtt0vJZjvN_BPxCeNEPJCjzTSG-IG999hF-ng4z9jD5cX98iq7-fn9evntJnPKgMykKBophSSPWnvERlUaAUuqV0Y1zpeVVwYrVbh5u1Kjb1beGWnQKFO7pinO2Jf9u5swPm4pTrZvo6Ouw4HGbbRa1KB1KV8FoRa1FDqB9R50YYwxkLeb0PYYdhaETdLt2ia3Nrm1Sbr9I92-zK2fDjO2q56af40HyzPw-QBgdNj5gINr4_-crEz6wvkee2472r15vv1xu0xV8RvlVpw8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18082072</pqid></control><display><type>article</type><title>Identification of a novel member of the T1R family of putative taste receptors</title><source>Wiley Free Content</source><source>MEDLINE</source><source>IngentaConnect Free/Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Sainz, Eduardo ; Korley, Julius N. ; Battey, James F. ; Sullivan, Susan L.</creator><creatorcontrib>Sainz, Eduardo ; Korley, Julius N. ; Battey, James F. ; Sullivan, Susan L.</creatorcontrib><description>In the gustatory system, the recognition of sugars, amino acids and bitter‐tasting compounds is the function of specialized G protein‐coupled receptors. Recently, two members of novel subfamily of G protein‐coupled receptors were proposed to function as taste receptors based on their specific expression in taste receptor cells. Here, we report the identification of a third member, T1R3, of this family of receptors. T1R3 maps near the telomere of mouse chromosome 4 rendering it a candidate for the Sac locus, a primary determinant of sweet preference in mice. Consistent with its candidacy for the Sac locus, T1R3 displays taste receptor cell‐specific expression. In addition, taster and non‐taster strains of mouse harbor different alleles of T1R3.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1046/j.1471-4159.2001.00292.x</identifier><identifier>PMID: 11331418</identifier><identifier>CODEN: JONRA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Amino Acid Sequence ; Animals ; Biological and medical sciences ; Chromosome Mapping ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; gustation ; gustatory system ; G protein‐coupled receptor ; In Situ Hybridization ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; mouse ; Olfactory Mucosa - chemistry ; Olfactory system and olfaction. Gustatory system and gustation ; Protein Sorting Signals ; Rats ; Receptors, Cell Surface - analysis ; Receptors, Cell Surface - chemistry ; Receptors, Cell Surface - genetics ; Receptors, G-Protein-Coupled ; Sac locus ; Sequence Alignment ; taste ; Taste - genetics ; Taste Buds - chemistry ; Tongue - cytology ; Vertebrates: nervous system and sense organs</subject><ispartof>Journal of neurochemistry, 2001-05, Vol.77 (3), p.896-903</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4912-203d2202efa77faad467a1a5e8b94dcf56f49a643c20057afdbfc929a9498cdd3</citedby><cites>FETCH-LOGICAL-c4912-203d2202efa77faad467a1a5e8b94dcf56f49a643c20057afdbfc929a9498cdd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1471-4159.2001.00292.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1471-4159.2001.00292.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1132692$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11331418$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sainz, Eduardo</creatorcontrib><creatorcontrib>Korley, Julius N.</creatorcontrib><creatorcontrib>Battey, James F.</creatorcontrib><creatorcontrib>Sullivan, Susan L.</creatorcontrib><title>Identification of a novel member of the T1R family of putative taste receptors</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>In the gustatory system, the recognition of sugars, amino acids and bitter‐tasting compounds is the function of specialized G protein‐coupled receptors. Recently, two members of novel subfamily of G protein‐coupled receptors were proposed to function as taste receptors based on their specific expression in taste receptor cells. Here, we report the identification of a third member, T1R3, of this family of receptors. T1R3 maps near the telomere of mouse chromosome 4 rendering it a candidate for the Sac locus, a primary determinant of sweet preference in mice. Consistent with its candidacy for the Sac locus, T1R3 displays taste receptor cell‐specific expression. In addition, taster and non‐taster strains of mouse harbor different alleles of T1R3.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chromosome Mapping</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>gustation</subject><subject>gustatory system</subject><subject>G protein‐coupled receptor</subject><subject>In Situ Hybridization</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Molecular Sequence Data</subject><subject>mouse</subject><subject>Olfactory Mucosa - chemistry</subject><subject>Olfactory system and olfaction. Gustatory system and gustation</subject><subject>Protein Sorting Signals</subject><subject>Rats</subject><subject>Receptors, Cell Surface - analysis</subject><subject>Receptors, Cell Surface - chemistry</subject><subject>Receptors, Cell Surface - genetics</subject><subject>Receptors, G-Protein-Coupled</subject><subject>Sac locus</subject><subject>Sequence Alignment</subject><subject>taste</subject><subject>Taste - genetics</subject><subject>Taste Buds - chemistry</subject><subject>Tongue - cytology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1P3DAQhi3UChbav1D5UPWW1OM4cXzgUK2gUCEqIThbs85YzSofi50F9t837q7a3uDk0etnPJ6HMQ4iB6Gqr-sclIZMQWlyKQTkQkgj85cjtvh78Y4t5lRmhVDyhJ3GuJ7BSlVwzE4AigIU1At2e93QMLW-dTi148BHz5EP4xN1vKd-RSEl0y_i93DHPfZtt0vJZjvN_BPxCeNEPJCjzTSG-IG999hF-ng4z9jD5cX98iq7-fn9evntJnPKgMykKBophSSPWnvERlUaAUuqV0Y1zpeVVwYrVbh5u1Kjb1beGWnQKFO7pinO2Jf9u5swPm4pTrZvo6Ouw4HGbbRa1KB1KV8FoRa1FDqB9R50YYwxkLeb0PYYdhaETdLt2ia3Nrm1Sbr9I92-zK2fDjO2q56af40HyzPw-QBgdNj5gINr4_-crEz6wvkee2472r15vv1xu0xV8RvlVpw8</recordid><startdate>200105</startdate><enddate>200105</enddate><creator>Sainz, Eduardo</creator><creator>Korley, Julius N.</creator><creator>Battey, James F.</creator><creator>Sullivan, Susan L.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200105</creationdate><title>Identification of a novel member of the T1R family of putative taste receptors</title><author>Sainz, Eduardo ; Korley, Julius N. ; Battey, James F. ; Sullivan, Susan L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4912-203d2202efa77faad467a1a5e8b94dcf56f49a643c20057afdbfc929a9498cdd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chromosome Mapping</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>gustation</topic><topic>gustatory system</topic><topic>G protein‐coupled receptor</topic><topic>In Situ Hybridization</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Molecular Sequence Data</topic><topic>mouse</topic><topic>Olfactory Mucosa - chemistry</topic><topic>Olfactory system and olfaction. Gustatory system and gustation</topic><topic>Protein Sorting Signals</topic><topic>Rats</topic><topic>Receptors, Cell Surface - analysis</topic><topic>Receptors, Cell Surface - chemistry</topic><topic>Receptors, Cell Surface - genetics</topic><topic>Receptors, G-Protein-Coupled</topic><topic>Sac locus</topic><topic>Sequence Alignment</topic><topic>taste</topic><topic>Taste - genetics</topic><topic>Taste Buds - chemistry</topic><topic>Tongue - cytology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sainz, Eduardo</creatorcontrib><creatorcontrib>Korley, Julius N.</creatorcontrib><creatorcontrib>Battey, James F.</creatorcontrib><creatorcontrib>Sullivan, Susan L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sainz, Eduardo</au><au>Korley, Julius N.</au><au>Battey, James F.</au><au>Sullivan, Susan L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of a novel member of the T1R family of putative taste receptors</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>2001-05</date><risdate>2001</risdate><volume>77</volume><issue>3</issue><spage>896</spage><epage>903</epage><pages>896-903</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><coden>JONRA9</coden><abstract>In the gustatory system, the recognition of sugars, amino acids and bitter‐tasting compounds is the function of specialized G protein‐coupled receptors. Recently, two members of novel subfamily of G protein‐coupled receptors were proposed to function as taste receptors based on their specific expression in taste receptor cells. Here, we report the identification of a third member, T1R3, of this family of receptors. T1R3 maps near the telomere of mouse chromosome 4 rendering it a candidate for the Sac locus, a primary determinant of sweet preference in mice. Consistent with its candidacy for the Sac locus, T1R3 displays taste receptor cell‐specific expression. In addition, taster and non‐taster strains of mouse harbor different alleles of T1R3.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>11331418</pmid><doi>10.1046/j.1471-4159.2001.00292.x</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3042 |
| ispartof | Journal of neurochemistry, 2001-05, Vol.77 (3), p.896-903 |
| issn | 0022-3042 1471-4159 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70817752 |
| source | Wiley Free Content; MEDLINE; IngentaConnect Free/Open Access Journals; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Amino Acid Sequence Animals Biological and medical sciences Chromosome Mapping Fundamental and applied biological sciences. Psychology Gene Expression gustation gustatory system G protein‐coupled receptor In Situ Hybridization Mice Mice, Inbred C57BL Molecular Sequence Data mouse Olfactory Mucosa - chemistry Olfactory system and olfaction. Gustatory system and gustation Protein Sorting Signals Rats Receptors, Cell Surface - analysis Receptors, Cell Surface - chemistry Receptors, Cell Surface - genetics Receptors, G-Protein-Coupled Sac locus Sequence Alignment taste Taste - genetics Taste Buds - chemistry Tongue - cytology Vertebrates: nervous system and sense organs |
| title | Identification of a novel member of the T1R family of putative taste receptors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T10%3A41%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Identification%20of%20a%20novel%20member%20of%20the%20T1R%20family%20of%20putative%20taste%20receptors&rft.jtitle=Journal%20of%20neurochemistry&rft.au=Sainz,%20Eduardo&rft.date=2001-05&rft.volume=77&rft.issue=3&rft.spage=896&rft.epage=903&rft.pages=896-903&rft.issn=0022-3042&rft.eissn=1471-4159&rft.coden=JONRA9&rft_id=info:doi/10.1046/j.1471-4159.2001.00292.x&rft_dat=%3Cproquest_cross%3E70817752%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18082072&rft_id=info:pmid/11331418&rfr_iscdi=true |