Synthesis and in-vitro Evaluation of Novel Low Molecular Weight Thiocarbamates as Inhibitors of Human Leukocyte Elastase

A series of novel low molecular weight thiocarbamate esters (1e-6e) were synthesized and evaluated as inhibitors of human leukocyte elastase (HLE). The thiocarbamate esters studied consist of a substituted primary or secondary aliphatic or aromatic amine and a 1-phenyl-1H-tetrazole-5-thiol (Table I)...

Ausführliche Beschreibung