Multiple Ramp Domains Are Required for Generation of Amylin Receptor Phenotype from the Calcitonin Receptor Gene Product

Calcitonin (CT), calcitonin gene-related peptide (CGRP), amylin, and adrenomedullin constitute a family of structurally related peptides that signal via either the calcitonin receptor-like receptor or the CT receptor, with receptor phenotype determined by coexpression of one of the three receptor ac...

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Veröffentlicht in:	Biochemical and biophysical research communications 2000-01, Vol.267 (1), p.368-372
Hauptverfasser:	Zumpe, Emma T., Tilakaratne, Nanda, Fraser, Neil J., Christopoulos, George, Foord, Steven M., Sexton, Patrick M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid - metabolism Animals Cercopithecus aethiops COS Cells Humans Intracellular Signaling Peptides and Proteins Islet Amyloid Polypeptide Kinetics Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Models, Molecular Phenotype Protein Structure, Secondary Radioligand Assay Rats Receptor Activity-Modifying Protein 1 Receptor Activity-Modifying Protein 2 Receptor Activity-Modifying Proteins Receptors, Calcitonin - chemistry Receptors, Calcitonin - genetics Receptors, Calcitonin - metabolism Receptors, Islet Amyloid Polypeptide Receptors, Peptide - genetics Receptors, Peptide - metabolism Recombinant Fusion Proteins - metabolism Salmon Transfection
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