TNF-alpha receptor signaling and IL-10 gene therapy regulate the innate and humoral immune responses to recombinant adenovirus in the lung

Recombinant adenovirus-mediated gene therapy has demonstrated great promise for the delivery of genes to the pulmonary epithelium. However, dose-dependent inflammation and local immune responses abbreviate transgene expression. The purpose of these studies was to determine the role of TNF-alpha and...

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Veröffentlicht in:	The Journal of immunology (1950) 2000-01, Vol.164 (1), p.443-451
Hauptverfasser:	Minter, R M, Rectenwald, J E, Fukuzuka, K, Tannahill, C L, La Face, D, Tsai, V, Ahmed, I, Hutchins, E, Moyer, R, Copeland, 3rd, E M, Moldawer, L L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviridae - immunology adenovirus Animals Antibodies, Viral - biosynthesis Antigens, CD - genetics Antigens, CD - metabolism beta-Galactosidase - biosynthesis beta-Galactosidase - genetics Female Genetic Therapy - methods Genetic Vectors - administration & dosage Genetic Vectors - therapeutic use Humans Immunity, Innate - genetics Interleukin-10 - administration & dosage Interleukin-10 - genetics Intubation, Intratracheal Lung - immunology Lung - virology Male Mice Mice, Inbred C57BL Mice, Knockout Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor - metabolism Receptors, Tumor Necrosis Factor, Type I Receptors, Tumor Necrosis Factor, Type II Recombinant Fusion Proteins - administration & dosage Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Signal Transduction - genetics Signal Transduction - immunology Time Factors Tumor necrosis factor-^a receptors Tumor Necrosis Factor-alpha - deficiency Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - physiology
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