Dynactin increases the processivity of the cytoplasmic dynein motor

Cytoplasmic dynein supports long-range intracellular movements of cargo in vivo but does not appear to be a processive motor protein by itself. We show here that the dynein activator, dynactin, binds microtubules and increases the average length of cytoplasmic-dynein-driven movements without affecti...

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Veröffentlicht in:	Nature cell biology 2000-01, Vol.2 (1), p.20-24
Hauptverfasser:	Schroer, Trina A, King, Stephen J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Adenosine Triphosphate - metabolism Adenosine Triphosphate - pharmacology Animals Antibodies - pharmacology Binding Sites - physiology Biological Transport - drug effects Biological Transport - physiology Biomedical and Life Sciences Cancer Research Cell Biology Chick Embryo Cytoplasm - enzymology Developmental Biology Dynactin Complex Dyneins - immunology Dyneins - metabolism Kinetics Life Sciences Microspheres Microtubule-Associated Proteins - chemistry Microtubule-Associated Proteins - immunology Microtubule-Associated Proteins - metabolism Microtubules - chemistry Microtubules - metabolism Molecular Motor Proteins - chemistry Molecular Motor Proteins - immunology Molecular Motor Proteins - metabolism Motility Proteins Stem Cells
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