SQ22536 and W-7 inhibit forskolin-induced cAMP elevation but not relaxation in newborn ovine pulmonary veins

The role of cAMP in forskolin-induced relaxation was studied in isolated pulmonary veins of newborn lambs (7–12 days). In vessels preconstricted with endothelin-1, forskolin at concentrations ≤10 −7 M had no effect on cAMP content and adenylyl cyclase activity but caused up to 50% relaxation. At hig...

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Veröffentlicht in:	European journal of pharmacology 2001-04, Vol.418 (1), p.111-116
Hauptverfasser:	Gao, Yuansheng, Raj, J.Usha
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Bromo Cyclic Adenosine Monophosphate - metabolism 8-Bromo Cyclic Adenosine Monophosphate - pharmacology Adenine - analogs & derivatives Adenine - pharmacology Adenylyl cyclase Adenylyl Cyclases - metabolism Animals Animals, Newborn Biological and medical sciences cAMP Cardiovascular system Cell Membrane - drug effects Cell Membrane - enzymology Cell Membrane - metabolism Colforsin - antagonists & inhibitors Colforsin - pharmacology Cyclic AMP - biosynthesis Cyclic AMP - metabolism Cyclic GMP - analogs & derivatives Cyclic GMP - pharmacology Endothelin-1 - pharmacology Enzyme Induction - drug effects Female Male Medical sciences Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology Pharmacology. Drug treatments Pulmonary vein Pulmonary Veins - cytology Pulmonary Veins - drug effects Pulmonary Veins - metabolism Pulmonary Veins - physiology Sheep - physiology Smooth muscle Sulfonamides - pharmacology Thionucleotides - pharmacology Time Factors Vascular Vasodilation - drug effects Vasodilator agents. Cerebral vasodilators
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