A novel amorphous calcium phosphate polymer ceramic for bone repair: I. Synthesis and characterization
Traditional materials for bone repair or replacements such as autografts and allografts have a limited supply and other complications. Thus, alternative materials need to be explored. Three‐dimensional, porous composites prepared from bioresorbable polymers and hydroxyapatite or other calcium phosph...
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| Veröffentlicht in: | Journal of biomedical materials research 2001, Vol.58 (3), p.295-301 |
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| creator | Ambrosio, Archel M. A. Sahota, Janmeet S. Khan, Yusuf Laurencin, Cato T. |
| description | Traditional materials for bone repair or replacements such as autografts and allografts have a limited supply and other complications. Thus, alternative materials need to be explored. Three‐dimensional, porous composites prepared from bioresorbable polymers and hydroxyapatite or other calcium phosphate ceramics are promising materials for the repair or replacement of diseased or damaged bone. However, in many cases the ceramic component of these composites is crystalline in nature, while bone apatite is made of a poorly crystalline, carbonated phosphate system. In this study, we synthesized a noncrystalline, carbonated calcium phosphate ceramic by carrying out the reaction within bioresorbable PLAGA microspheres using a modified emulsion/solvent evaporation technique, making each individual microsphere a composite. Sintering the composite microspheres together yielded a bioresorbable, porous, 3‐dimensional scaffold that may be ideal for tissue ingrowth, making this composite scaffold potentially suitable for bone repair applications. © 2001 John Wiley & Sons, Inc. J Biomed Mater Res (Appl Biomater) 58: 295–301, 2001 |
| doi_str_mv | 10.1002/1097-4636(2001)58:3<295::AID-JBM1020>3.0.CO;2-8 |
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Synthesis and characterization</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Ambrosio, Archel M. A. ; Sahota, Janmeet S. ; Khan, Yusuf ; Laurencin, Cato T.</creator><creatorcontrib>Ambrosio, Archel M. A. ; Sahota, Janmeet S. ; Khan, Yusuf ; Laurencin, Cato T.</creatorcontrib><description>Traditional materials for bone repair or replacements such as autografts and allografts have a limited supply and other complications. Thus, alternative materials need to be explored. Three‐dimensional, porous composites prepared from bioresorbable polymers and hydroxyapatite or other calcium phosphate ceramics are promising materials for the repair or replacement of diseased or damaged bone. However, in many cases the ceramic component of these composites is crystalline in nature, while bone apatite is made of a poorly crystalline, carbonated phosphate system. In this study, we synthesized a noncrystalline, carbonated calcium phosphate ceramic by carrying out the reaction within bioresorbable PLAGA microspheres using a modified emulsion/solvent evaporation technique, making each individual microsphere a composite. Sintering the composite microspheres together yielded a bioresorbable, porous, 3‐dimensional scaffold that may be ideal for tissue ingrowth, making this composite scaffold potentially suitable for bone repair applications. © 2001 John Wiley & Sons, Inc. J Biomed Mater Res (Appl Biomater) 58: 295–301, 2001</description><identifier>ISSN: 0021-9304</identifier><identifier>EISSN: 1097-4636</identifier><identifier>DOI: 10.1002/1097-4636(2001)58:3<295::AID-JBM1020>3.0.CO;2-8</identifier><identifier>PMID: 11319744</identifier><identifier>CODEN: JBMRBG</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>3-D scaffold ; Biological and medical sciences ; bioresorbable ; bone repair ; Bone Substitutes - chemical synthesis ; Bone Substitutes - chemistry ; Calcium Phosphates - chemical synthesis ; Calcium Phosphates - chemistry ; Ceramics - chemical synthesis ; Ceramics - chemistry ; composite ; Humans ; In Vitro Techniques ; Materials Testing ; Medical sciences ; Microscopy, Electron, Scanning ; microsphere ; Microspheres ; noncrystalline calcium phosphate ; Particle Size ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. 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A.</creatorcontrib><creatorcontrib>Sahota, Janmeet S.</creatorcontrib><creatorcontrib>Khan, Yusuf</creatorcontrib><creatorcontrib>Laurencin, Cato T.</creatorcontrib><title>A novel amorphous calcium phosphate polymer ceramic for bone repair: I. Synthesis and characterization</title><title>Journal of biomedical materials research</title><addtitle>J. Biomed. Mater. Res</addtitle><description>Traditional materials for bone repair or replacements such as autografts and allografts have a limited supply and other complications. Thus, alternative materials need to be explored. Three‐dimensional, porous composites prepared from bioresorbable polymers and hydroxyapatite or other calcium phosphate ceramics are promising materials for the repair or replacement of diseased or damaged bone. However, in many cases the ceramic component of these composites is crystalline in nature, while bone apatite is made of a poorly crystalline, carbonated phosphate system. In this study, we synthesized a noncrystalline, carbonated calcium phosphate ceramic by carrying out the reaction within bioresorbable PLAGA microspheres using a modified emulsion/solvent evaporation technique, making each individual microsphere a composite. Sintering the composite microspheres together yielded a bioresorbable, porous, 3‐dimensional scaffold that may be ideal for tissue ingrowth, making this composite scaffold potentially suitable for bone repair applications. © 2001 John Wiley & Sons, Inc. J Biomed Mater Res (Appl Biomater) 58: 295–301, 2001</description><subject>3-D scaffold</subject><subject>Biological and medical sciences</subject><subject>bioresorbable</subject><subject>bone repair</subject><subject>Bone Substitutes - chemical synthesis</subject><subject>Bone Substitutes - chemistry</subject><subject>Calcium Phosphates - chemical synthesis</subject><subject>Calcium Phosphates - chemistry</subject><subject>Ceramics - chemical synthesis</subject><subject>Ceramics - chemistry</subject><subject>composite</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Materials Testing</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>microsphere</subject><subject>Microspheres</subject><subject>noncrystalline calcium phosphate</subject><subject>Particle Size</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology. Biomaterials. Equipments</subject><subject>X-Ray Diffraction</subject><issn>0021-9304</issn><issn>1097-4636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU2P0zAQhi0EYkvhLyBfQHBIsT1JHBeEVAoshV0qsQscR47jqIZ8YadA-fW4atm9IMHFlkePX4_nIURyNuOMiSecKZmkOeSPBGP8cVbM4ZlQ2Xy-WL1M3r4450yw5zBjs-X6qUiKG2RydeMmmcQEnihg6Qm5E8IXxphSwG-TE86BK5mmE1IvaNd_tw3Vbe-HTb8N1OjGuG1L4ykMGz1aOvTNrrWeGut16wyte0_LvrPU20E7P6erGb3YdePGBheo7ipqNtprM1rvfunR9d1dcqvWTbD3jvuUfHz96nL5Jjlbn66Wi7PEpJCxRMdFA6iyKnPBZVVxycEymYJiaZHnKpUgSllXVSmULOsSFGcmy0plSp5BBVPy8JA7-P7b1oYRWxeMbRrd2fg3lKzgQmTwT1DkhQQlVQTXB9D4PgRvaxy8a7XfIWe4d4T7ieN-4rh3hFmBgNERYnSER0exxHC5RoFFTLx_fHpbtra6zjtKicCDI6BDlFF73RkXrrmUpwziYKbk4sD9cI3d_Xdff2_rTymmJodUF0b78ypV-6-YS5AZfn5_inL56cO7c7hEgN9rGsTa</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>Ambrosio, Archel M. A.</creator><creator>Sahota, Janmeet S.</creator><creator>Khan, Yusuf</creator><creator>Laurencin, Cato T.</creator><general>John Wiley & Sons, Inc</general><general>John Wiley & Sons</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope></search><sort><creationdate>2001</creationdate><title>A novel amorphous calcium phosphate polymer ceramic for bone repair: I. Synthesis and characterization</title><author>Ambrosio, Archel M. A. ; Sahota, Janmeet S. ; Khan, Yusuf ; Laurencin, Cato T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4350-a350a339bdb6217dd1713e074390486694732b7fddb297bfb3910c55b9cb153d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>3-D scaffold</topic><topic>Biological and medical sciences</topic><topic>bioresorbable</topic><topic>bone repair</topic><topic>Bone Substitutes - chemical synthesis</topic><topic>Bone Substitutes - chemistry</topic><topic>Calcium Phosphates - chemical synthesis</topic><topic>Calcium Phosphates - chemistry</topic><topic>Ceramics - chemical synthesis</topic><topic>Ceramics - chemistry</topic><topic>composite</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Materials Testing</topic><topic>Medical sciences</topic><topic>Microscopy, Electron, Scanning</topic><topic>microsphere</topic><topic>Microspheres</topic><topic>noncrystalline calcium phosphate</topic><topic>Particle Size</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Technology. Biomaterials. Equipments</topic><topic>X-Ray Diffraction</topic><toplevel>online_resources</toplevel><creatorcontrib>Ambrosio, Archel M. 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However, in many cases the ceramic component of these composites is crystalline in nature, while bone apatite is made of a poorly crystalline, carbonated phosphate system. In this study, we synthesized a noncrystalline, carbonated calcium phosphate ceramic by carrying out the reaction within bioresorbable PLAGA microspheres using a modified emulsion/solvent evaporation technique, making each individual microsphere a composite. Sintering the composite microspheres together yielded a bioresorbable, porous, 3‐dimensional scaffold that may be ideal for tissue ingrowth, making this composite scaffold potentially suitable for bone repair applications. © 2001 John Wiley & Sons, Inc. J Biomed Mater Res (Appl Biomater) 58: 295–301, 2001</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>11319744</pmid><doi>10.1002/1097-4636(2001)58:3<295::AID-JBM1020>3.0.CO;2-8</doi><tpages>7</tpages></addata></record> |
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| subjects | 3-D scaffold Biological and medical sciences bioresorbable bone repair Bone Substitutes - chemical synthesis Bone Substitutes - chemistry Calcium Phosphates - chemical synthesis Calcium Phosphates - chemistry Ceramics - chemical synthesis Ceramics - chemistry composite Humans In Vitro Techniques Materials Testing Medical sciences Microscopy, Electron, Scanning microsphere Microspheres noncrystalline calcium phosphate Particle Size Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments X-Ray Diffraction |
| title | A novel amorphous calcium phosphate polymer ceramic for bone repair: I. Synthesis and characterization |
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