Secretion of Surfactant Protein C, an Integral Membrane Protein, Requires the N-terminal Propeptide

Proteolytic processing of surfactant protein C (SP-C) proprotein in multivesicular bodies of alveolar type II cells results in a 35-residue mature peptide, consisting of a transmembrane domain and a 10-residue extramembrane domain. SP-C mature peptide is stored in lamellar bodies (a lysosomal-like o...

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Veröffentlicht in:	The Journal of biological chemistry 2001-05, Vol.276 (18), p.14658-14664
Hauptverfasser:	Conkright, Juliana Johnson, Bridges, James P., Na, Cheng-Lun, Voorhout, Wim F., Trapnell, Bruce, Glasser, Stephan W., Weaver, Timothy E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Endocytosis Humans Membrane Proteins - chemistry Membrane Proteins - metabolism PC12 Cells Proteolipids - chemistry Proteolipids - metabolism Pulmonary Surfactants - chemistry Pulmonary Surfactants - metabolism Rats
Online-Zugang:	Volltext
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