Effects of Reactive Oxygen and Nitrogen Metabolites on Eotaxin-Induced Eosinophil Chemotactic Activity In Vitro

Peroxynitrite, an oxidant generated by the interaction between superoxide and nitric oxide (NO), has been implicated in the etiology of numerous disease processes. Several studies have shown that peroxynitrite-induced protein nitration may compromise enzyme and protein function. We hypothesized that...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2000-01, Vol.22 (1), p.61-67
Hauptverfasser:	Sato, Etsuro, Simpson, Keith L, Grisham, Matthew B, Koyama, Sekiya, Robbins, Richard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites - drug effects Chemokine CCL11 Chemokines, CC Chemotactic Factors, Eosinophil - metabolism Chemotactic Factors, Eosinophil - physiology Chemotaxis, Leukocyte - drug effects Cytokines - metabolism Cytokines - physiology Eosinophils - drug effects Eosinophils - metabolism Eosinophils - physiology Humans Hydrazines - pharmacology Nitrates - pharmacology Nitric Oxide - pharmacology Nitrogen - metabolism Nitrogen - physiology Reactive Oxygen Species - metabolism Reactive Oxygen Species - physiology Reducing Agents - pharmacology Superoxides - metabolism Superoxides - pharmacology Xanthine - metabolism Xanthine Oxidase - metabolism
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