Leptin concentrations in maternal serum and amniotic fluid during the second trimenon: differential relation to fetal gender and maternal morphometry
Leptin, a hormone produced by adipocytes, provides information on the availability of fat stores to the hypothalamus and acts as an afferent satiety signal regulating appetite and energy expenditure in both rodents and humans [Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positiona...
Gespeichert in:
| Veröffentlicht in: | European journal of obstetrics & gynecology and reproductive biology 1999-10, Vol.86 (2), p.151-157 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 157 |
|---|---|
| container_issue | 2 |
| container_start_page | 151 |
| container_title | European journal of obstetrics & gynecology and reproductive biology |
| container_volume | 86 |
| creator | Schubring, C. Prohaska, F. Prohaska, A. Englaro, P. Blum, W. Siebler, T. Kratzsch, J. Kiess, W. |
| description | Leptin, a hormone produced by adipocytes, provides information on the availability of fat stores to the hypothalamus and acts as an afferent satiety signal regulating appetite and energy expenditure in both rodents and humans [Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425–432; Sinha MK. Human leptin: the hormone of adipose tissue. Eur J Endocrinol 1997;136:461–4; Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995;269:546–9; Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995;269:543–6; Saladin R, De Vos P, Guerre-Millo M, Leturque A, Girard J, Staels B, Auwern J. Transient increase in obese gene expression after food intake or insulin administration. Nature 1995;377:527–9; Campfield LA, Smith FJ, Burn P. The OB protein (leptin) pathway – a link between adipose tissue mass and central neural networks. Horm Metab Res 1996;28:619–632; Blum WF, Kiess W, Rascher W, editors. Leptin – the voice of the adipose tissue. J&J Edition, JA Barth Verlag, Heidelberg, 1997]. In addition, leptin is thought to play an important role for reproduction and during gestation [Kiess W, Blum WF, Aubert ML. Leptin, puberty and reproductive function: lessons from animal studies and observations in humans. Eur J Endocrinol 1997;138:1–4; Barash IA, Cheung CC, Wigle DS, Ren H, Kabitting EB, Kuijer JL, Clifton DK, Steiner RA. Leptin is a metabolic signal to the reproductive system. Endocrinology 1996;133:3144–47; Chehab F, Lim M, Lu R. Correction of the sterility defect in homocygous obese female mice by treatment with the human recombinant leptin. Nature Genetics 1996;12:318–20; Kiess W, Schubring C, Prohaska F, Englaro P, Rascher W, Attanasio A, Blum WF. Leptin in amniotic fluid at term and at midgestation. In: Blum WF, Kiess W, Rascher W, editors. Leptin – the voice of the adipose tissue. J&J Edition, JA Barth Verlag, Heidelberg, 1997]. The purpose of this study was to gain more insight into a putative role of leptin during midgestation. Therefore we have measured leptin concentrations in maternal serum and amniotic fluid using a specific radioimmunoassay (RIA) employing human recombinant leptin for tracer and standard prepa |
| doi_str_mv | 10.1016/S0301-2115(99)00059-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70810636</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0301211599000597</els_id><sourcerecordid>70810636</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-57e05138af33cfa5a57bc1f02a984926810378d4dc73fdcf35b3d13cea81f20a3</originalsourceid><addsrcrecordid>eNqFkcFuEzEQhi1ERUPhEUA-IASHBXsdr9e9IFQBRYrEAThbE3vcGu3awfYi9UH6vrhJVLj1ZGn0zTee-Ql5wdk7zvjw_jsTjHc95_KN1m8ZY1J36hFZ8VH1nRrk-jFZ3SOn5GkpvxrEhNBPyClnkmk1ihW53eCuhkhtihZjzVBDioW2ygwVc4SJFszLTCE6CnMMqQZL_bQER92SQ7yi9Rob0wSO1hxmjCmeUxe8x9yMoRkyTnsvrYl6rK1yhdFh3kvv58wp767TjDXfPCMnHqaCz4_vGfn5-dOPi8tu8-3L14uPm84KzWonFTLJxQheCOtBglRbyz3rQY9r3Q8jZ0KNbu2sEt5ZL-RWOC4swsh9z0CckdcH7y6n3wuWauZQLE4TRExLMYo1xSCGBsoDaHMqJaM3u7Yq5BvDmbnLw-zzMHfHNlqbfR5Gtb6XxwHLdkb3X9chgAa8OgJQLEw-Q7Sh_ON0r_WaN-zDAcN2jT8Bsyk2YIvMhYy2GpfCAz_5CwN2qsA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70810636</pqid></control><display><type>article</type><title>Leptin concentrations in maternal serum and amniotic fluid during the second trimenon: differential relation to fetal gender and maternal morphometry</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Schubring, C. ; Prohaska, F. ; Prohaska, A. ; Englaro, P. ; Blum, W. ; Siebler, T. ; Kratzsch, J. ; Kiess, W.</creator><creatorcontrib>Schubring, C. ; Prohaska, F. ; Prohaska, A. ; Englaro, P. ; Blum, W. ; Siebler, T. ; Kratzsch, J. ; Kiess, W.</creatorcontrib><description><![CDATA[Leptin, a hormone produced by adipocytes, provides information on the availability of fat stores to the hypothalamus and acts as an afferent satiety signal regulating appetite and energy expenditure in both rodents and humans [Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425–432; Sinha MK. Human leptin: the hormone of adipose tissue. Eur J Endocrinol 1997;136:461–4; Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995;269:546–9; Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995;269:543–6; Saladin R, De Vos P, Guerre-Millo M, Leturque A, Girard J, Staels B, Auwern J. Transient increase in obese gene expression after food intake or insulin administration. Nature 1995;377:527–9; Campfield LA, Smith FJ, Burn P. The OB protein (leptin) pathway – a link between adipose tissue mass and central neural networks. Horm Metab Res 1996;28:619–632; Blum WF, Kiess W, Rascher W, editors. Leptin – the voice of the adipose tissue. J&J Edition, JA Barth Verlag, Heidelberg, 1997]. In addition, leptin is thought to play an important role for reproduction and during gestation [Kiess W, Blum WF, Aubert ML. Leptin, puberty and reproductive function: lessons from animal studies and observations in humans. Eur J Endocrinol 1997;138:1–4; Barash IA, Cheung CC, Wigle DS, Ren H, Kabitting EB, Kuijer JL, Clifton DK, Steiner RA. Leptin is a metabolic signal to the reproductive system. Endocrinology 1996;133:3144–47; Chehab F, Lim M, Lu R. Correction of the sterility defect in homocygous obese female mice by treatment with the human recombinant leptin. Nature Genetics 1996;12:318–20; Kiess W, Schubring C, Prohaska F, Englaro P, Rascher W, Attanasio A, Blum WF. Leptin in amniotic fluid at term and at midgestation. In: Blum WF, Kiess W, Rascher W, editors. Leptin – the voice of the adipose tissue. J&J Edition, JA Barth Verlag, Heidelberg, 1997]. The purpose of this study was to gain more insight into a putative role of leptin during midgestation. Therefore we have measured leptin concentrations in maternal serum and amniotic fluid using a specific radioimmunoassay (RIA) employing human recombinant leptin for tracer and standard preparation [Blum WF, Kiess W, Rascher W, editors, Leptin – The voice of the adipose tissue. J&J Edition, JA Barth Verlag, Heidelberg, 1997; Blum WF, Englaro P, Heiman M, Attanasio Am, Kiess W, Rascher W. Clinical studies of serum leptin. In: Blum WF, Kiess W, Rascher W. Leptin – The voice of the adipose tissue. J&J Edition, JA Barth Verlag, Heidelberg, 1997; Blum WF, Englaro P, Heiman M, Attanasio AM, Kiess W, Rascher W. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage and testosterone. J Clin Endocrinol Metab 1997;82:2904–2910]. In addition, estriol, hCG and alphafetoprotein were measured in maternal serum. We have asked whether or not leptin concentrations in maternal serum and amniotic fluid were related to maternal BMI and skinfold thickness. Sixty-three healthy pregnant women who were later found to deliver healthy, term children and as a control group 39 healthy non-pregnant women were included in the study. Maternal age was 35 years (median, range 24–46) and gestational age at amniocentesis 14–17 weeks (range). Leptin concentrations in maternal serum at amniocentesis were 3.2–51.9 ng/ml (range) and in amniotic fluid 2.3–30.2 ng/ml (range). Serum leptin levels from non-pregnant women were 2.7–55.4 ng/ml (range). Maternal leptin serum concentrations at the time of amniocentesis correlated significantly with BMI (r=0.54, P<0.001), and with maternal skinfold measurements (iliac r=0.53, P<0.001, subscapular r=0.44, P<0.001; triceps r=0.39, P<0.002 and biceps r=0.41, P<0.001). Similar relations of leptin serum levels and BMI (r=0.53, P=0.001) and skinfold thickness (iliac r=0.65, P<0.001, subscapular r=0.55, P<0.001, triceps r=0.34, P<0.036 and biceps r=0.38, P<0.016) were found in the non-pregnant control group. In contrast, leptin levels in amniotic fluid did not correlate with maternal BMI, skinfold thickness and leptin levels in maternal serum at midgestation. Interestingly, the amniotic fluid leptin levels of girls were significantly higher than those of boys (2.6–30.2 ng/ml (range) versus 2.3–15.6 ng/ml (range)). In conclusion, high leptin concentrations are found in maternal serum and amniotic fluid at midgestation. Maternal leptin levels and leptin levels in amniotic fluid seem to be derived from different sources. We hypothesize that leptin plays gestation-specific differential roles for the mother and the fetus.]]></description><identifier>ISSN: 0301-2115</identifier><identifier>EISSN: 1872-7654</identifier><identifier>DOI: 10.1016/S0301-2115(99)00059-7</identifier><identifier>PMID: 10509783</identifier><identifier>CODEN: EOGRAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; alpha-Fetoproteins - metabolism ; Amniotic fluid ; Amniotic Fluid - metabolism ; Biological and medical sciences ; BMI ; Body Mass Index ; Chorionic Gonadotropin - blood ; Estriol - blood ; Female ; Fetus ; Gynecology. Andrology. Obstetrics ; Humans ; Leptin ; Leptin - blood ; Leptin - metabolism ; Male ; Management. Prenatal diagnosis ; Medical sciences ; Middle Aged ; Midgestation ; Pregnancy ; Pregnancy Trimester, Second ; Pregnancy. Fetus. Placenta ; Sex Factors ; Skinfold Thickness ; Skinfolds ; Time Factors</subject><ispartof>European journal of obstetrics & gynecology and reproductive biology, 1999-10, Vol.86 (2), p.151-157</ispartof><rights>1999 Elsevier Science Ireland Ltd</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-57e05138af33cfa5a57bc1f02a984926810378d4dc73fdcf35b3d13cea81f20a3</citedby><cites>FETCH-LOGICAL-c390t-57e05138af33cfa5a57bc1f02a984926810378d4dc73fdcf35b3d13cea81f20a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0301-2115(99)00059-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1929941$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10509783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schubring, C.</creatorcontrib><creatorcontrib>Prohaska, F.</creatorcontrib><creatorcontrib>Prohaska, A.</creatorcontrib><creatorcontrib>Englaro, P.</creatorcontrib><creatorcontrib>Blum, W.</creatorcontrib><creatorcontrib>Siebler, T.</creatorcontrib><creatorcontrib>Kratzsch, J.</creatorcontrib><creatorcontrib>Kiess, W.</creatorcontrib><title>Leptin concentrations in maternal serum and amniotic fluid during the second trimenon: differential relation to fetal gender and maternal morphometry</title><title>European journal of obstetrics & gynecology and reproductive biology</title><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><description><![CDATA[Leptin, a hormone produced by adipocytes, provides information on the availability of fat stores to the hypothalamus and acts as an afferent satiety signal regulating appetite and energy expenditure in both rodents and humans [Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425–432; Sinha MK. Human leptin: the hormone of adipose tissue. Eur J Endocrinol 1997;136:461–4; Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995;269:546–9; Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995;269:543–6; Saladin R, De Vos P, Guerre-Millo M, Leturque A, Girard J, Staels B, Auwern J. Transient increase in obese gene expression after food intake or insulin administration. Nature 1995;377:527–9; Campfield LA, Smith FJ, Burn P. The OB protein (leptin) pathway – a link between adipose tissue mass and central neural networks. Horm Metab Res 1996;28:619–632; Blum WF, Kiess W, Rascher W, editors. Leptin – the voice of the adipose tissue. J&J Edition, JA Barth Verlag, Heidelberg, 1997]. In addition, leptin is thought to play an important role for reproduction and during gestation [Kiess W, Blum WF, Aubert ML. Leptin, puberty and reproductive function: lessons from animal studies and observations in humans. Eur J Endocrinol 1997;138:1–4; Barash IA, Cheung CC, Wigle DS, Ren H, Kabitting EB, Kuijer JL, Clifton DK, Steiner RA. Leptin is a metabolic signal to the reproductive system. Endocrinology 1996;133:3144–47; Chehab F, Lim M, Lu R. Correction of the sterility defect in homocygous obese female mice by treatment with the human recombinant leptin. Nature Genetics 1996;12:318–20; Kiess W, Schubring C, Prohaska F, Englaro P, Rascher W, Attanasio A, Blum WF. Leptin in amniotic fluid at term and at midgestation. In: Blum WF, Kiess W, Rascher W, editors. Leptin – the voice of the adipose tissue. J&J Edition, JA Barth Verlag, Heidelberg, 1997]. The purpose of this study was to gain more insight into a putative role of leptin during midgestation. Therefore we have measured leptin concentrations in maternal serum and amniotic fluid using a specific radioimmunoassay (RIA) employing human recombinant leptin for tracer and standard preparation [Blum WF, Kiess W, Rascher W, editors, Leptin – The voice of the adipose tissue. J&J Edition, JA Barth Verlag, Heidelberg, 1997; Blum WF, Englaro P, Heiman M, Attanasio Am, Kiess W, Rascher W. Clinical studies of serum leptin. In: Blum WF, Kiess W, Rascher W. Leptin – The voice of the adipose tissue. J&J Edition, JA Barth Verlag, Heidelberg, 1997; Blum WF, Englaro P, Heiman M, Attanasio AM, Kiess W, Rascher W. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage and testosterone. J Clin Endocrinol Metab 1997;82:2904–2910]. In addition, estriol, hCG and alphafetoprotein were measured in maternal serum. We have asked whether or not leptin concentrations in maternal serum and amniotic fluid were related to maternal BMI and skinfold thickness. Sixty-three healthy pregnant women who were later found to deliver healthy, term children and as a control group 39 healthy non-pregnant women were included in the study. Maternal age was 35 years (median, range 24–46) and gestational age at amniocentesis 14–17 weeks (range). Leptin concentrations in maternal serum at amniocentesis were 3.2–51.9 ng/ml (range) and in amniotic fluid 2.3–30.2 ng/ml (range). Serum leptin levels from non-pregnant women were 2.7–55.4 ng/ml (range). Maternal leptin serum concentrations at the time of amniocentesis correlated significantly with BMI (r=0.54, P<0.001), and with maternal skinfold measurements (iliac r=0.53, P<0.001, subscapular r=0.44, P<0.001; triceps r=0.39, P<0.002 and biceps r=0.41, P<0.001). Similar relations of leptin serum levels and BMI (r=0.53, P=0.001) and skinfold thickness (iliac r=0.65, P<0.001, subscapular r=0.55, P<0.001, triceps r=0.34, P<0.036 and biceps r=0.38, P<0.016) were found in the non-pregnant control group. In contrast, leptin levels in amniotic fluid did not correlate with maternal BMI, skinfold thickness and leptin levels in maternal serum at midgestation. Interestingly, the amniotic fluid leptin levels of girls were significantly higher than those of boys (2.6–30.2 ng/ml (range) versus 2.3–15.6 ng/ml (range)). In conclusion, high leptin concentrations are found in maternal serum and amniotic fluid at midgestation. Maternal leptin levels and leptin levels in amniotic fluid seem to be derived from different sources. We hypothesize that leptin plays gestation-specific differential roles for the mother and the fetus.]]></description><subject>Adult</subject><subject>alpha-Fetoproteins - metabolism</subject><subject>Amniotic fluid</subject><subject>Amniotic Fluid - metabolism</subject><subject>Biological and medical sciences</subject><subject>BMI</subject><subject>Body Mass Index</subject><subject>Chorionic Gonadotropin - blood</subject><subject>Estriol - blood</subject><subject>Female</subject><subject>Fetus</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Leptin</subject><subject>Leptin - blood</subject><subject>Leptin - metabolism</subject><subject>Male</subject><subject>Management. Prenatal diagnosis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Midgestation</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Second</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Sex Factors</subject><subject>Skinfold Thickness</subject><subject>Skinfolds</subject><subject>Time Factors</subject><issn>0301-2115</issn><issn>1872-7654</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFuEzEQhi1ERUPhEUA-IASHBXsdr9e9IFQBRYrEAThbE3vcGu3awfYi9UH6vrhJVLj1ZGn0zTee-Ql5wdk7zvjw_jsTjHc95_KN1m8ZY1J36hFZ8VH1nRrk-jFZ3SOn5GkpvxrEhNBPyClnkmk1ihW53eCuhkhtihZjzVBDioW2ygwVc4SJFszLTCE6CnMMqQZL_bQER92SQ7yi9Rob0wSO1hxmjCmeUxe8x9yMoRkyTnsvrYl6rK1yhdFh3kvv58wp767TjDXfPCMnHqaCz4_vGfn5-dOPi8tu8-3L14uPm84KzWonFTLJxQheCOtBglRbyz3rQY9r3Q8jZ0KNbu2sEt5ZL-RWOC4swsh9z0CckdcH7y6n3wuWauZQLE4TRExLMYo1xSCGBsoDaHMqJaM3u7Yq5BvDmbnLw-zzMHfHNlqbfR5Gtb6XxwHLdkb3X9chgAa8OgJQLEw-Q7Sh_ON0r_WaN-zDAcN2jT8Bsyk2YIvMhYy2GpfCAz_5CwN2qsA</recordid><startdate>19991001</startdate><enddate>19991001</enddate><creator>Schubring, C.</creator><creator>Prohaska, F.</creator><creator>Prohaska, A.</creator><creator>Englaro, P.</creator><creator>Blum, W.</creator><creator>Siebler, T.</creator><creator>Kratzsch, J.</creator><creator>Kiess, W.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991001</creationdate><title>Leptin concentrations in maternal serum and amniotic fluid during the second trimenon: differential relation to fetal gender and maternal morphometry</title><author>Schubring, C. ; Prohaska, F. ; Prohaska, A. ; Englaro, P. ; Blum, W. ; Siebler, T. ; Kratzsch, J. ; Kiess, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-57e05138af33cfa5a57bc1f02a984926810378d4dc73fdcf35b3d13cea81f20a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>alpha-Fetoproteins - metabolism</topic><topic>Amniotic fluid</topic><topic>Amniotic Fluid - metabolism</topic><topic>Biological and medical sciences</topic><topic>BMI</topic><topic>Body Mass Index</topic><topic>Chorionic Gonadotropin - blood</topic><topic>Estriol - blood</topic><topic>Female</topic><topic>Fetus</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Leptin</topic><topic>Leptin - blood</topic><topic>Leptin - metabolism</topic><topic>Male</topic><topic>Management. Prenatal diagnosis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Midgestation</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, Second</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Sex Factors</topic><topic>Skinfold Thickness</topic><topic>Skinfolds</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schubring, C.</creatorcontrib><creatorcontrib>Prohaska, F.</creatorcontrib><creatorcontrib>Prohaska, A.</creatorcontrib><creatorcontrib>Englaro, P.</creatorcontrib><creatorcontrib>Blum, W.</creatorcontrib><creatorcontrib>Siebler, T.</creatorcontrib><creatorcontrib>Kratzsch, J.</creatorcontrib><creatorcontrib>Kiess, W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schubring, C.</au><au>Prohaska, F.</au><au>Prohaska, A.</au><au>Englaro, P.</au><au>Blum, W.</au><au>Siebler, T.</au><au>Kratzsch, J.</au><au>Kiess, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leptin concentrations in maternal serum and amniotic fluid during the second trimenon: differential relation to fetal gender and maternal morphometry</atitle><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><date>1999-10-01</date><risdate>1999</risdate><volume>86</volume><issue>2</issue><spage>151</spage><epage>157</epage><pages>151-157</pages><issn>0301-2115</issn><eissn>1872-7654</eissn><coden>EOGRAL</coden><abstract><![CDATA[Leptin, a hormone produced by adipocytes, provides information on the availability of fat stores to the hypothalamus and acts as an afferent satiety signal regulating appetite and energy expenditure in both rodents and humans [Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425–432; Sinha MK. Human leptin: the hormone of adipose tissue. Eur J Endocrinol 1997;136:461–4; Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995;269:546–9; Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995;269:543–6; Saladin R, De Vos P, Guerre-Millo M, Leturque A, Girard J, Staels B, Auwern J. Transient increase in obese gene expression after food intake or insulin administration. Nature 1995;377:527–9; Campfield LA, Smith FJ, Burn P. The OB protein (leptin) pathway – a link between adipose tissue mass and central neural networks. Horm Metab Res 1996;28:619–632; Blum WF, Kiess W, Rascher W, editors. Leptin – the voice of the adipose tissue. J&J Edition, JA Barth Verlag, Heidelberg, 1997]. In addition, leptin is thought to play an important role for reproduction and during gestation [Kiess W, Blum WF, Aubert ML. Leptin, puberty and reproductive function: lessons from animal studies and observations in humans. Eur J Endocrinol 1997;138:1–4; Barash IA, Cheung CC, Wigle DS, Ren H, Kabitting EB, Kuijer JL, Clifton DK, Steiner RA. Leptin is a metabolic signal to the reproductive system. Endocrinology 1996;133:3144–47; Chehab F, Lim M, Lu R. Correction of the sterility defect in homocygous obese female mice by treatment with the human recombinant leptin. Nature Genetics 1996;12:318–20; Kiess W, Schubring C, Prohaska F, Englaro P, Rascher W, Attanasio A, Blum WF. Leptin in amniotic fluid at term and at midgestation. In: Blum WF, Kiess W, Rascher W, editors. Leptin – the voice of the adipose tissue. J&J Edition, JA Barth Verlag, Heidelberg, 1997]. The purpose of this study was to gain more insight into a putative role of leptin during midgestation. Therefore we have measured leptin concentrations in maternal serum and amniotic fluid using a specific radioimmunoassay (RIA) employing human recombinant leptin for tracer and standard preparation [Blum WF, Kiess W, Rascher W, editors, Leptin – The voice of the adipose tissue. J&J Edition, JA Barth Verlag, Heidelberg, 1997; Blum WF, Englaro P, Heiman M, Attanasio Am, Kiess W, Rascher W. Clinical studies of serum leptin. In: Blum WF, Kiess W, Rascher W. Leptin – The voice of the adipose tissue. J&J Edition, JA Barth Verlag, Heidelberg, 1997; Blum WF, Englaro P, Heiman M, Attanasio AM, Kiess W, Rascher W. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage and testosterone. J Clin Endocrinol Metab 1997;82:2904–2910]. In addition, estriol, hCG and alphafetoprotein were measured in maternal serum. We have asked whether or not leptin concentrations in maternal serum and amniotic fluid were related to maternal BMI and skinfold thickness. Sixty-three healthy pregnant women who were later found to deliver healthy, term children and as a control group 39 healthy non-pregnant women were included in the study. Maternal age was 35 years (median, range 24–46) and gestational age at amniocentesis 14–17 weeks (range). Leptin concentrations in maternal serum at amniocentesis were 3.2–51.9 ng/ml (range) and in amniotic fluid 2.3–30.2 ng/ml (range). Serum leptin levels from non-pregnant women were 2.7–55.4 ng/ml (range). Maternal leptin serum concentrations at the time of amniocentesis correlated significantly with BMI (r=0.54, P<0.001), and with maternal skinfold measurements (iliac r=0.53, P<0.001, subscapular r=0.44, P<0.001; triceps r=0.39, P<0.002 and biceps r=0.41, P<0.001). Similar relations of leptin serum levels and BMI (r=0.53, P=0.001) and skinfold thickness (iliac r=0.65, P<0.001, subscapular r=0.55, P<0.001, triceps r=0.34, P<0.036 and biceps r=0.38, P<0.016) were found in the non-pregnant control group. In contrast, leptin levels in amniotic fluid did not correlate with maternal BMI, skinfold thickness and leptin levels in maternal serum at midgestation. Interestingly, the amniotic fluid leptin levels of girls were significantly higher than those of boys (2.6–30.2 ng/ml (range) versus 2.3–15.6 ng/ml (range)). In conclusion, high leptin concentrations are found in maternal serum and amniotic fluid at midgestation. Maternal leptin levels and leptin levels in amniotic fluid seem to be derived from different sources. We hypothesize that leptin plays gestation-specific differential roles for the mother and the fetus.]]></abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10509783</pmid><doi>10.1016/S0301-2115(99)00059-7</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0301-2115 |
| ispartof | European journal of obstetrics & gynecology and reproductive biology, 1999-10, Vol.86 (2), p.151-157 |
| issn | 0301-2115 1872-7654 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70810636 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult alpha-Fetoproteins - metabolism Amniotic fluid Amniotic Fluid - metabolism Biological and medical sciences BMI Body Mass Index Chorionic Gonadotropin - blood Estriol - blood Female Fetus Gynecology. Andrology. Obstetrics Humans Leptin Leptin - blood Leptin - metabolism Male Management. Prenatal diagnosis Medical sciences Middle Aged Midgestation Pregnancy Pregnancy Trimester, Second Pregnancy. Fetus. Placenta Sex Factors Skinfold Thickness Skinfolds Time Factors |
| title | Leptin concentrations in maternal serum and amniotic fluid during the second trimenon: differential relation to fetal gender and maternal morphometry |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T14%3A11%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Leptin%20concentrations%20in%20maternal%20serum%20and%20amniotic%20fluid%20during%20the%20second%20trimenon:%20differential%20relation%20to%20fetal%20gender%20and%20maternal%20morphometry&rft.jtitle=European%20journal%20of%20obstetrics%20&%20gynecology%20and%20reproductive%20biology&rft.au=Schubring,%20C.&rft.date=1999-10-01&rft.volume=86&rft.issue=2&rft.spage=151&rft.epage=157&rft.pages=151-157&rft.issn=0301-2115&rft.eissn=1872-7654&rft.coden=EOGRAL&rft_id=info:doi/10.1016/S0301-2115(99)00059-7&rft_dat=%3Cproquest_cross%3E70810636%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70810636&rft_id=info:pmid/10509783&rft_els_id=S0301211599000597&rfr_iscdi=true |