Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates

Mechanical forces play a major role in the regulation of cell adhesion and cytoskeletal organization. In order to explore the molecular mechanism underlying this regulation, we have investigated the relationship between local force applied by the cell to the substrate and the assembly of focal adhes...

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Veröffentlicht in:	Nature cell biology 2001-05, Vol.3 (5), p.466-472
Hauptverfasser:	Balaban, Nathalie Q., Schwarz, Ulrich S., Riveline, Daniel, Goichberg, Polina, Tzur, Gila, Sabanay, Ilana, Mahalu, Diana, Safran, Sam, Bershadsky, Alexander, Addadi, Lia, Geiger, Benjamin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Animals Biology Biomedical and Life Sciences Cancer Research Cell Adhesion Cell adhesion & migration Cell adhesion molecules Cell Biology Cells, Cultured Developmental Biology Diagnostic Imaging - methods Elastomers - metabolism Fibroblasts Fibroblasts - ultrastructure Fluorescence Focal Adhesions - metabolism Green Fluorescent Proteins Humans Life Sciences Luminescent Proteins - metabolism Microscopy Microscopy, Electron Microscopy, Fluorescence Microscopy, Phase-Contrast Morphogenesis Myocardium - cytology Physiological aspects Rats Recombinant Fusion Proteins - metabolism Semiconductor research Space life sciences Stem Cells Stress, Mechanical Substrates Time Factors Vinculin - metabolism
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