ULTRASTRUCTURAL EVIDENCE THAT APOPTOSIS IS THE MECHANISM BY WHICH HUMAN AMYLIN EVOKES DEATH IN RINm5F PANCREATIC ISLET β-CELLS

A view is emerging that human amylin (HA) kills pancreatic islet β-cells by apoptosis. This study strengthens this view by documenting time-dependent morphological and ultrastructural changes in 10μm HA-treated cultured RINm5F islet β-cells. Membrane blebbing and microvilli loss were the earliest de...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell biology international 2001-04, Vol.25 (4), p.339-350
Hauptverfasser:	Saafi, Etuate L., Konarkowska, Barbara, Zhang, Shaoping, Kistler, Joerg, Cooper, Garth J.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	amylin Amyloid - metabolism Amyloid - pharmacology apoptosis Apoptosis - drug effects Apoptosis - physiology Cell Membrane - drug effects Cell Membrane - ultrastructure Cell Nucleus - drug effects Cell Nucleus - ultrastructure cellular morphology Chromatin - drug effects Chromatin - ultrastructure DNA Fragmentation - drug effects Humans islet amyloid Islet Amyloid Polypeptide Islets of Langerhans - drug effects Islets of Langerhans - physiology Islets of Langerhans - ultrastructure Microscopy, Electron, Scanning Microvilli - drug effects Microvilli - ultrastructure RINm5F islet β-cells scanning electron microscopy Time Factors transmission electron microscopy type-2 diabetes ultrastructure
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!