The Oncogenic LIM-Only Transcription Factor Lmo2 Regulates Angiogenesis but Not Vasculogenesis in Mice

The LMO2 gene is activated by chromosomal translocations in human T cell acute leukemias, but in mouse embryogenesis, Lmo2 is essential for initiation of yolk sac and definitive hematopoiesis. The LMO2 protein comprises two LIM-zinc-finger-like protein interaction modules and functions by interactio...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-01, Vol.97 (1), p.320-324
Hauptverfasser:	Yamada, Yoshihiro, Pannell, Richard, Forster, Alan, Rabbitts, Terence H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Alleles Angiogenesis Animals beta-Galactosidase Biological Sciences Blastocyst Blood cells Cardiovascular system Chimera - genetics DNA-Binding Proteins - genetics Embryonic and Fetal Development Embryos Endothelial cells Endothelium, Vascular - metabolism Genes Hematopoiesis In Situ Hybridization Lac Operon Leukemia LIM Domain Proteins Limb buds Lmo2 protein Metalloproteins - genetics Mice Neovascularization, Physiologic - genetics Proteins Proto-Oncogene Proteins - genetics Recombination, Genetic Rodents Stem Cells - metabolism T lymphocytes Transcription Factors - genetics
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