Diagnostic accuracy of fine-needle aspiration and frozen section in nodular thyroid disease
Objective: To assess the diagnostic accuracy of fine-needle aspiration (FNA) and frozen section (FS) in nodular thyroid disease. Setting: Tertiary care academic medical center. Study Design: Retrospective review of 139 consecutive patients undergoing surgery for nodular thyroid disease. FNA and FS s...
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| Veröffentlicht in: | Otolaryngology-head and neck surgery 2001-05, Vol.124 (5), p.531-536 |
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| container_title | Otolaryngology-head and neck surgery |
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| creator | Mandell, David L. Genden, Eric M. Mechanick, Jeffrey I. Bergman, Donald A. Biller, Hugh F. Urken, Mark L. |
| description | Objective: To assess the diagnostic accuracy of fine-needle aspiration (FNA) and frozen section (FS) in nodular thyroid disease.
Setting: Tertiary care academic medical center.
Study Design: Retrospective review of 139 consecutive patients undergoing surgery for nodular thyroid disease. FNA and FS sensitivity, specificity, and accuracy were calculated with respect to permanent section histology.
Results: Among 63 patients with an FNA interpreted as either benign (n = 38) or malignant (n = 25), FNA was accurate (sensitivity 89%, specificity 97%, accuracy 94%). FS identified only one case of carcinoma missed by FNA. Among 76 patients with a “suspicious” FNA, FS was reasonably accurate (sensitivity 67%, specificity 100%, accuracy 89%), but was deferred in 50% of cases.
Conclusion: Given high FNA accuracy, more selective use of FS is suggested.
Significance: The study results will assist with intra-institutional patient counseling and intraoperative decision-making with respect to FNA and FS results in patients with nodular thyroid disease. (Otolaryngol Head Neck Surg 2001;124:531-6.) |
| doi_str_mv | 10.1067/mhn.2001.115372 |
| format | Article |
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Setting: Tertiary care academic medical center.
Study Design: Retrospective review of 139 consecutive patients undergoing surgery for nodular thyroid disease. FNA and FS sensitivity, specificity, and accuracy were calculated with respect to permanent section histology.
Results: Among 63 patients with an FNA interpreted as either benign (n = 38) or malignant (n = 25), FNA was accurate (sensitivity 89%, specificity 97%, accuracy 94%). FS identified only one case of carcinoma missed by FNA. Among 76 patients with a “suspicious” FNA, FS was reasonably accurate (sensitivity 67%, specificity 100%, accuracy 89%), but was deferred in 50% of cases.
Conclusion: Given high FNA accuracy, more selective use of FS is suggested.
Significance: The study results will assist with intra-institutional patient counseling and intraoperative decision-making with respect to FNA and FS results in patients with nodular thyroid disease. (Otolaryngol Head Neck Surg 2001;124:531-6.)</description><identifier>ISSN: 0194-5998</identifier><identifier>EISSN: 1097-6817</identifier><identifier>DOI: 10.1067/mhn.2001.115372</identifier><identifier>PMID: 11337658</identifier><language>eng</language><publisher>Los Angeles, CA: Mosby, Inc</publisher><subject>Adenoma - pathology ; Adenoma - surgery ; Adult ; Aged ; Aged, 80 and over ; Biopsy, Needle ; Carcinoma, Papillary, Follicular - pathology ; Carcinoma, Papillary, Follicular - surgery ; Female ; Frozen Sections ; Humans ; Intraoperative Period ; Male ; Middle Aged ; Retrospective Studies ; Sensitivity and Specificity ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - surgery ; Thyroid Nodule - pathology ; Thyroid Nodule - surgery ; Thyroidectomy</subject><ispartof>Otolaryngology-head and neck surgery, 2001-05, Vol.124 (5), p.531-536</ispartof><rights>2001 American Academy of Otolarynology - Head and Neck Surgery foundation, Inc.</rights><rights>2001 SAGE Publications</rights><rights>2001 American Association of Otolaryngology‐Head and Neck Surgery Foundation (AAO‐HNSF)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5231-c17eb082e055e58ae240275fcfa94f64ce324ef73ac7762b155ce50a8bae5df93</citedby><cites>FETCH-LOGICAL-c5231-c17eb082e055e58ae240275fcfa94f64ce324ef73ac7762b155ce50a8bae5df93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1067/mhn.2001.115372$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1067/mhn.2001.115372$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,777,781,1412,21800,27905,27906,43602,43603,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11337658$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mandell, David L.</creatorcontrib><creatorcontrib>Genden, Eric M.</creatorcontrib><creatorcontrib>Mechanick, Jeffrey I.</creatorcontrib><creatorcontrib>Bergman, Donald A.</creatorcontrib><creatorcontrib>Biller, Hugh F.</creatorcontrib><creatorcontrib>Urken, Mark L.</creatorcontrib><title>Diagnostic accuracy of fine-needle aspiration and frozen section in nodular thyroid disease</title><title>Otolaryngology-head and neck surgery</title><addtitle>Otolaryngol Head Neck Surg</addtitle><description>Objective: To assess the diagnostic accuracy of fine-needle aspiration (FNA) and frozen section (FS) in nodular thyroid disease.
Setting: Tertiary care academic medical center.
Study Design: Retrospective review of 139 consecutive patients undergoing surgery for nodular thyroid disease. FNA and FS sensitivity, specificity, and accuracy were calculated with respect to permanent section histology.
Results: Among 63 patients with an FNA interpreted as either benign (n = 38) or malignant (n = 25), FNA was accurate (sensitivity 89%, specificity 97%, accuracy 94%). FS identified only one case of carcinoma missed by FNA. Among 76 patients with a “suspicious” FNA, FS was reasonably accurate (sensitivity 67%, specificity 100%, accuracy 89%), but was deferred in 50% of cases.
Conclusion: Given high FNA accuracy, more selective use of FS is suggested.
Significance: The study results will assist with intra-institutional patient counseling and intraoperative decision-making with respect to FNA and FS results in patients with nodular thyroid disease. (Otolaryngol Head Neck Surg 2001;124:531-6.)</description><subject>Adenoma - pathology</subject><subject>Adenoma - surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biopsy, Needle</subject><subject>Carcinoma, Papillary, Follicular - pathology</subject><subject>Carcinoma, Papillary, Follicular - surgery</subject><subject>Female</subject><subject>Frozen Sections</subject><subject>Humans</subject><subject>Intraoperative Period</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroid Nodule - pathology</subject><subject>Thyroid Nodule - surgery</subject><subject>Thyroidectomy</subject><issn>0194-5998</issn><issn>1097-6817</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTFP5DAQRi10CPaAmg65uoosthPHSQkLHEgIGqgorFl7DEZZe8_egJZff-GyEtVBNdLofZ9Gbwg55GzKWa1OFs9hKhjjU85lqcQWmXDWqqJuuPpBJoy3VSHbttklP3N-YYzVtVI7ZJfzslS1bCbk8dzDU4h55Q0FY_oEZk2jo84HLAKi7ZBCXvoEKx8DhWCpS_EdA81o_q18oCHavoNEV8_rFL2l1meEjPtk20GX8WAz98jD5cX97Kq4uft9PTu9KYwUJS8MVzhnjUAmJcoGUFRMKOmMg7ZydWWwFBU6VYJRqhZzLqVByaCZA0rr2nKP_Bp7lyn-6TGv9MJng10HAWOftWINaypZDeDJCJoUc07o9DL5BaS15kx_-NSDT_3hU48-h8TRprqfL9B-8huBA6BG4M13uP6uT99d3Z5dClVKPiSPx2SGJ9QvsU9hkPTFJe2I42Dy1WPS2XgMBq1Pwye0jf6_2b-EB6PU</recordid><startdate>200105</startdate><enddate>200105</enddate><creator>Mandell, David L.</creator><creator>Genden, Eric M.</creator><creator>Mechanick, Jeffrey I.</creator><creator>Bergman, Donald A.</creator><creator>Biller, Hugh F.</creator><creator>Urken, Mark L.</creator><general>Mosby, Inc</general><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>200105</creationdate><title>Diagnostic accuracy of fine-needle aspiration and frozen section in nodular thyroid disease</title><author>Mandell, David L. ; Genden, Eric M. ; Mechanick, Jeffrey I. ; Bergman, Donald A. ; Biller, Hugh F. ; Urken, Mark L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5231-c17eb082e055e58ae240275fcfa94f64ce324ef73ac7762b155ce50a8bae5df93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adenoma - pathology</topic><topic>Adenoma - surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biopsy, Needle</topic><topic>Carcinoma, Papillary, Follicular - pathology</topic><topic>Carcinoma, Papillary, Follicular - surgery</topic><topic>Female</topic><topic>Frozen Sections</topic><topic>Humans</topic><topic>Intraoperative Period</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroid Nodule - pathology</topic><topic>Thyroid Nodule - surgery</topic><topic>Thyroidectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mandell, David L.</creatorcontrib><creatorcontrib>Genden, Eric M.</creatorcontrib><creatorcontrib>Mechanick, Jeffrey I.</creatorcontrib><creatorcontrib>Bergman, Donald A.</creatorcontrib><creatorcontrib>Biller, Hugh F.</creatorcontrib><creatorcontrib>Urken, Mark L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Otolaryngology-head and neck surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mandell, David L.</au><au>Genden, Eric M.</au><au>Mechanick, Jeffrey I.</au><au>Bergman, Donald A.</au><au>Biller, Hugh F.</au><au>Urken, Mark L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic accuracy of fine-needle aspiration and frozen section in nodular thyroid disease</atitle><jtitle>Otolaryngology-head and neck surgery</jtitle><addtitle>Otolaryngol Head Neck Surg</addtitle><date>2001-05</date><risdate>2001</risdate><volume>124</volume><issue>5</issue><spage>531</spage><epage>536</epage><pages>531-536</pages><issn>0194-5998</issn><eissn>1097-6817</eissn><abstract>Objective: To assess the diagnostic accuracy of fine-needle aspiration (FNA) and frozen section (FS) in nodular thyroid disease.
Setting: Tertiary care academic medical center.
Study Design: Retrospective review of 139 consecutive patients undergoing surgery for nodular thyroid disease. FNA and FS sensitivity, specificity, and accuracy were calculated with respect to permanent section histology.
Results: Among 63 patients with an FNA interpreted as either benign (n = 38) or malignant (n = 25), FNA was accurate (sensitivity 89%, specificity 97%, accuracy 94%). FS identified only one case of carcinoma missed by FNA. Among 76 patients with a “suspicious” FNA, FS was reasonably accurate (sensitivity 67%, specificity 100%, accuracy 89%), but was deferred in 50% of cases.
Conclusion: Given high FNA accuracy, more selective use of FS is suggested.
Significance: The study results will assist with intra-institutional patient counseling and intraoperative decision-making with respect to FNA and FS results in patients with nodular thyroid disease. (Otolaryngol Head Neck Surg 2001;124:531-6.)</abstract><cop>Los Angeles, CA</cop><pub>Mosby, Inc</pub><pmid>11337658</pmid><doi>10.1067/mhn.2001.115372</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; SAGE Complete A-Z List; Alma/SFX Local Collection |
| subjects | Adenoma - pathology Adenoma - surgery Adult Aged Aged, 80 and over Biopsy, Needle Carcinoma, Papillary, Follicular - pathology Carcinoma, Papillary, Follicular - surgery Female Frozen Sections Humans Intraoperative Period Male Middle Aged Retrospective Studies Sensitivity and Specificity Thyroid Neoplasms - pathology Thyroid Neoplasms - surgery Thyroid Nodule - pathology Thyroid Nodule - surgery Thyroidectomy |
| title | Diagnostic accuracy of fine-needle aspiration and frozen section in nodular thyroid disease |
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