Different mechanisms mediate the rejection of porcine neurons and endothelial cells transplanted into the rat brain

: In order to investigate the early cellular responses mediating xenograft rejection in the brain, porcine aortic endothelial cells (PAEC) or porcine fetal mesencephalic neurons (PNEU) were transplanted into the striatum of LEW.1A rats. PAEC were detected with a specific anti‐β1 integrin antibody, a...

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Veröffentlicht in:	Xenotransplantation (Københaven) 2001-05, Vol.8 (2), p.136-148
Hauptverfasser:	Rémy, Séverine, Canova, Cécile, Daguin-Nerrière, Véronique, Martin, Caroline, Melchior, Benoît, Neveu, Isabelle, Charreau, Béatrice, Soulillou, Jean-Paul, Brachet, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD Antigens, Neoplasm Antigens, Surface apoptosis Avian Proteins Basigin Blood Proteins brain Brain Tissue Transplantation - adverse effects Brain Tissue Transplantation - immunology Corpus Striatum - surgery endothelium Endothelium, Vascular - transplantation Graft Rejection - etiology Graft Rejection - immunology Graft Rejection - pathology lymphocyte Lymphocytes - immunology macrophage Macrophages - immunology Male Membrane Glycoproteins - metabolism mesencephalic neurons- pig Neurons - radiation effects polymorphonuclear Rats Rats, Inbred Lew Receptors, Antigen, T-Cell, alpha-beta - metabolism rejection Swine Transplantation, Heterologous - adverse effects Transplantation, Heterologous - immunology xenotransplantation
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