Laparoscopic biliopancreatic diversion with a duodenal switch for morbid obesity: a feasibility study in pigs
Biliopancreatic diversion with a duodenal switch is an emerging open procedure that appears as effective as other bariatric operations. Our goal was to determine the safety and feasibility of performing this procedure using a laparoscopic approach in a porcine model. Six 50-kg pigs underwent surgery...
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| Veröffentlicht in: | Journal of laparoendoscopic & advanced surgical techniques. Part A 2001-04, Vol.11 (2), p.79-83 |
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| container_title | Journal of laparoendoscopic & advanced surgical techniques. Part A |
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| creator | de Csepel, J Burpee, S Jossart, G Andrei, V Murakami, Y Benavides, S Gagner, M |
| description | Biliopancreatic diversion with a duodenal switch is an emerging open procedure that appears as effective as other bariatric operations. Our goal was to determine the safety and feasibility of performing this procedure using a laparoscopic approach in a porcine model.
Six 50-kg pigs underwent surgery. Intake was restricted with a sleeve gastrectomy, and malabsorption was obtained by creating a Roux-en-Y. The Roux limb served as a 150-cm alimentary channel following anastomosis to a transected proximal duodenum, while the other limb, or biliopancreatic channel, transported digestive juices. Where the two limbs joined, a 100-cm common channel was formed.
The operation was completed in a mean time of 4.5 hours. Two of the six pigs had an intraoperative duodenoenterostomy anastomotic leak detected on methylene blue testing. This leakage was thought to be related to pig anatomy and is not expected to be a problem in humans. At necropsy, all anastomoses were patent, and there were no enteroenterostomy leaks or mesenteric torsions.
On the basis of the porcine model, laparoscopic biliopancreatic diversion with a duodenal switch is anticipated to be feasible and safe in humans. Substantial weight loss combined with the benefits of laparoscopic surgery can be expected. |
| doi_str_mv | 10.1089/109264201750162293 |
| format | Article |
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Six 50-kg pigs underwent surgery. Intake was restricted with a sleeve gastrectomy, and malabsorption was obtained by creating a Roux-en-Y. The Roux limb served as a 150-cm alimentary channel following anastomosis to a transected proximal duodenum, while the other limb, or biliopancreatic channel, transported digestive juices. Where the two limbs joined, a 100-cm common channel was formed.
The operation was completed in a mean time of 4.5 hours. Two of the six pigs had an intraoperative duodenoenterostomy anastomotic leak detected on methylene blue testing. This leakage was thought to be related to pig anatomy and is not expected to be a problem in humans. At necropsy, all anastomoses were patent, and there were no enteroenterostomy leaks or mesenteric torsions.
On the basis of the porcine model, laparoscopic biliopancreatic diversion with a duodenal switch is anticipated to be feasible and safe in humans. Substantial weight loss combined with the benefits of laparoscopic surgery can be expected.</description><identifier>ISSN: 1092-6429</identifier><identifier>EISSN: 1557-9034</identifier><identifier>DOI: 10.1089/109264201750162293</identifier><identifier>PMID: 11327131</identifier><language>eng</language><publisher>United States</publisher><subject>Anastomosis, Roux-en-Y ; Animals ; Biliopancreatic Diversion - methods ; Disease Models, Animal ; Duodenum - surgery ; Feasibility Studies ; Gastrectomy ; Laparoscopy ; Obesity, Morbid - surgery ; Swine</subject><ispartof>Journal of laparoendoscopic & advanced surgical techniques. Part A, 2001-04, Vol.11 (2), p.79-83</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c299t-ebaf75df86225508083c983e4c73cc5c99403322f1396a2a17391db2e17109893</citedby><cites>FETCH-LOGICAL-c299t-ebaf75df86225508083c983e4c73cc5c99403322f1396a2a17391db2e17109893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3042,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11327131$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Csepel, J</creatorcontrib><creatorcontrib>Burpee, S</creatorcontrib><creatorcontrib>Jossart, G</creatorcontrib><creatorcontrib>Andrei, V</creatorcontrib><creatorcontrib>Murakami, Y</creatorcontrib><creatorcontrib>Benavides, S</creatorcontrib><creatorcontrib>Gagner, M</creatorcontrib><title>Laparoscopic biliopancreatic diversion with a duodenal switch for morbid obesity: a feasibility study in pigs</title><title>Journal of laparoendoscopic & advanced surgical techniques. Part A</title><addtitle>J Laparoendosc Adv Surg Tech A</addtitle><description>Biliopancreatic diversion with a duodenal switch is an emerging open procedure that appears as effective as other bariatric operations. Our goal was to determine the safety and feasibility of performing this procedure using a laparoscopic approach in a porcine model.
Six 50-kg pigs underwent surgery. Intake was restricted with a sleeve gastrectomy, and malabsorption was obtained by creating a Roux-en-Y. The Roux limb served as a 150-cm alimentary channel following anastomosis to a transected proximal duodenum, while the other limb, or biliopancreatic channel, transported digestive juices. Where the two limbs joined, a 100-cm common channel was formed.
The operation was completed in a mean time of 4.5 hours. Two of the six pigs had an intraoperative duodenoenterostomy anastomotic leak detected on methylene blue testing. This leakage was thought to be related to pig anatomy and is not expected to be a problem in humans. At necropsy, all anastomoses were patent, and there were no enteroenterostomy leaks or mesenteric torsions.
On the basis of the porcine model, laparoscopic biliopancreatic diversion with a duodenal switch is anticipated to be feasible and safe in humans. Substantial weight loss combined with the benefits of laparoscopic surgery can be expected.</description><subject>Anastomosis, Roux-en-Y</subject><subject>Animals</subject><subject>Biliopancreatic Diversion - methods</subject><subject>Disease Models, Animal</subject><subject>Duodenum - surgery</subject><subject>Feasibility Studies</subject><subject>Gastrectomy</subject><subject>Laparoscopy</subject><subject>Obesity, Morbid - surgery</subject><subject>Swine</subject><issn>1092-6429</issn><issn>1557-9034</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkEtLxDAUhYMozjj6B1xIVu6quUk7adzJ4AsKbnRd0iR1Im1Tk1TpvzfDDLjwbu6D7x44B6FLIDdASnELRNB1TgnwgsCaUsGO0BKKgmeCsPw4zQnIEiEW6CyET5JKsPwULQAY5cBgifpKjtK7oNxoFW5sZ90oB-WNjGnX9tv4YN2Af2zcYon15LQZZIdDOqgtbp3HvfON1dg1Jtg43yWqNTLYnVaccYiTnrEd8Gg_wjk6aWUXzMWhr9D748Pb5jmrXp9eNvdVpqgQMTONbHmh2zKZKgpSkpIpUTKTK86UKpQQOWGM0haYWEsqgTMBuqEGeLJcCrZC13vd0buvyYRY9zYo03VyMG4KNU-anFJIIN2DKmUQvGnr0dte-rkGUu9Crv-HnJ6uDupT0xv993JIlf0CSk93kw</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>de Csepel, J</creator><creator>Burpee, S</creator><creator>Jossart, G</creator><creator>Andrei, V</creator><creator>Murakami, Y</creator><creator>Benavides, S</creator><creator>Gagner, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010401</creationdate><title>Laparoscopic biliopancreatic diversion with a duodenal switch for morbid obesity: a feasibility study in pigs</title><author>de Csepel, J ; Burpee, S ; Jossart, G ; Andrei, V ; Murakami, Y ; Benavides, S ; Gagner, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c299t-ebaf75df86225508083c983e4c73cc5c99403322f1396a2a17391db2e17109893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Anastomosis, Roux-en-Y</topic><topic>Animals</topic><topic>Biliopancreatic Diversion - methods</topic><topic>Disease Models, Animal</topic><topic>Duodenum - surgery</topic><topic>Feasibility Studies</topic><topic>Gastrectomy</topic><topic>Laparoscopy</topic><topic>Obesity, Morbid - surgery</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Csepel, J</creatorcontrib><creatorcontrib>Burpee, S</creatorcontrib><creatorcontrib>Jossart, G</creatorcontrib><creatorcontrib>Andrei, V</creatorcontrib><creatorcontrib>Murakami, Y</creatorcontrib><creatorcontrib>Benavides, S</creatorcontrib><creatorcontrib>Gagner, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of laparoendoscopic & advanced surgical techniques. Part A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Csepel, J</au><au>Burpee, S</au><au>Jossart, G</au><au>Andrei, V</au><au>Murakami, Y</au><au>Benavides, S</au><au>Gagner, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Laparoscopic biliopancreatic diversion with a duodenal switch for morbid obesity: a feasibility study in pigs</atitle><jtitle>Journal of laparoendoscopic & advanced surgical techniques. Part A</jtitle><addtitle>J Laparoendosc Adv Surg Tech A</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>11</volume><issue>2</issue><spage>79</spage><epage>83</epage><pages>79-83</pages><issn>1092-6429</issn><eissn>1557-9034</eissn><abstract>Biliopancreatic diversion with a duodenal switch is an emerging open procedure that appears as effective as other bariatric operations. Our goal was to determine the safety and feasibility of performing this procedure using a laparoscopic approach in a porcine model.
Six 50-kg pigs underwent surgery. Intake was restricted with a sleeve gastrectomy, and malabsorption was obtained by creating a Roux-en-Y. The Roux limb served as a 150-cm alimentary channel following anastomosis to a transected proximal duodenum, while the other limb, or biliopancreatic channel, transported digestive juices. Where the two limbs joined, a 100-cm common channel was formed.
The operation was completed in a mean time of 4.5 hours. Two of the six pigs had an intraoperative duodenoenterostomy anastomotic leak detected on methylene blue testing. This leakage was thought to be related to pig anatomy and is not expected to be a problem in humans. At necropsy, all anastomoses were patent, and there were no enteroenterostomy leaks or mesenteric torsions.
On the basis of the porcine model, laparoscopic biliopancreatic diversion with a duodenal switch is anticipated to be feasible and safe in humans. Substantial weight loss combined with the benefits of laparoscopic surgery can be expected.</abstract><cop>United States</cop><pmid>11327131</pmid><doi>10.1089/109264201750162293</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1092-6429 |
| ispartof | Journal of laparoendoscopic & advanced surgical techniques. Part A, 2001-04, Vol.11 (2), p.79-83 |
| issn | 1092-6429 1557-9034 |
| language | eng |
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| source | Mary Ann Liebert Online Subscription; MEDLINE |
| subjects | Anastomosis, Roux-en-Y Animals Biliopancreatic Diversion - methods Disease Models, Animal Duodenum - surgery Feasibility Studies Gastrectomy Laparoscopy Obesity, Morbid - surgery Swine |
| title | Laparoscopic biliopancreatic diversion with a duodenal switch for morbid obesity: a feasibility study in pigs |
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