A Novel Apoptotic Pathway Induced by Nerve Growth Factor-mediated TrkA Activation in Medulloblastoma

Nerve growth factor (NGF) induces apoptosis in a human medulloblastoma cell line (MED283) engineered to express TrkA (MED283-TrkA) (Muragaki, Y., Chou, T. T., Kaplan, D. R., Trojanowski, J. Q., and Lee, V. M. (1997) J. Neurosci. 17, 530â542). To dissect the molecular signaling pathway that mediate...

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Veröffentlicht in:	The Journal of biological chemistry 2000-01, Vol.275 (1), p.565-570
Hauptverfasser:	Chou, T T, Trojanowski, J Q, Lee, V M
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Butadienes - pharmacology Caspases - metabolism Cerebellar Neoplasms - metabolism ERK kinase Flavonoids - pharmacology Humans Isoenzymes medulloblastoma Medulloblastoma - metabolism Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Models, Biological Nerve Growth Factor - pharmacology Nitriles - pharmacology Phosphatidylinositol 3-Kinases Phospholipase C gamma Phosphorylation ras Proteins - metabolism Receptor, trkA - metabolism Signal Transduction Type C Phospholipases
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