High performance liquid chromatographic determination of 123-I labeled tamoxifen metabolites in human plasma
A high-performance liquid chromatographic procedure for the quantitation of [ 123I]Iodomethyl-N,N-diethyltamoxifen (ITX), a radioligand for human breast cancer imaging, in human plasma is described. Separation was effected on a RP-C18 column, using a mixture of acetonitrile-water-triethylamine (70/3...
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| Veröffentlicht in: | Nuclear medicine and biology 2001-04, Vol.28 (3), p.335-338 |
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| container_title | Nuclear medicine and biology |
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| creator | De Vos, Filip Van de Wielea, Christophe Vandecapelle, Marleen Dierckx, Rudi Andre Slegers, Guido |
| description | A high-performance liquid chromatographic procedure for the quantitation of [
123I]Iodomethyl-N,N-diethyltamoxifen (ITX), a radioligand for human breast cancer imaging, in human plasma is described. Separation was effected on a RP-C18 column, using a mixture of acetonitrile-water-triethylamine (70/30/0.5, v/v). ITX was rapidly cleared from human plasma and metabolites appeared as early as 7.5 min p.i. Quantitative assessment of metabolites in plasma over time allowed recalculation of the ITX plasma time-activity curve. Implications of ITX metabolite formation for breast tumour imaging are discussed. |
| doi_str_mv | 10.1016/S0969-8051(01)00195-0 |
| format | Article |
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123I]Iodomethyl-N,N-diethyltamoxifen (ITX), a radioligand for human breast cancer imaging, in human plasma is described. Separation was effected on a RP-C18 column, using a mixture of acetonitrile-water-triethylamine (70/30/0.5, v/v). ITX was rapidly cleared from human plasma and metabolites appeared as early as 7.5 min p.i. Quantitative assessment of metabolites in plasma over time allowed recalculation of the ITX plasma time-activity curve. Implications of ITX metabolite formation for breast tumour imaging are discussed.</description><identifier>ISSN: 0969-8051</identifier><identifier>EISSN: 1872-9614</identifier><identifier>DOI: 10.1016/S0969-8051(01)00195-0</identifier><identifier>PMID: 11323246</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>123I ; Aged ; Anticarcinogenic Agents - blood ; Anticarcinogenic Agents - metabolism ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; Contrast media. Radiopharmaceuticals ; Endocrine glands. Genital system. Mammary gland ; Female ; Humans ; Injections, Intravenous ; Investigative techniques, diagnostic techniques (general aspects) ; Iodine Radioisotopes - blood ; Iodine Radioisotopes - metabolism ; Iodine Radioisotopes - pharmacokinetics ; Medical sciences ; Metabolites ; Middle Aged ; Pharmacology. Drug treatments ; Radionuclide investigations ; Tamoxifen ; Tamoxifen - analogs & derivatives ; Tamoxifen - blood ; Tamoxifen - metabolism ; Tamoxifen - pharmacokinetics</subject><ispartof>Nuclear medicine and biology, 2001-04, Vol.28 (3), p.335-338</ispartof><rights>2001 Elsevier Science Inc.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-d9c70c177528eed1ebc078f2133aac9dc6a7b26b4a927df0ff34484f665418bc3</citedby><cites>FETCH-LOGICAL-c455t-d9c70c177528eed1ebc078f2133aac9dc6a7b26b4a927df0ff34484f665418bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0969805101001950$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=995839$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11323246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Vos, Filip</creatorcontrib><creatorcontrib>Van de Wielea, Christophe</creatorcontrib><creatorcontrib>Vandecapelle, Marleen</creatorcontrib><creatorcontrib>Dierckx, Rudi Andre</creatorcontrib><creatorcontrib>Slegers, Guido</creatorcontrib><title>High performance liquid chromatographic determination of 123-I labeled tamoxifen metabolites in human plasma</title><title>Nuclear medicine and biology</title><addtitle>Nucl Med Biol</addtitle><description>A high-performance liquid chromatographic procedure for the quantitation of [
123I]Iodomethyl-N,N-diethyltamoxifen (ITX), a radioligand for human breast cancer imaging, in human plasma is described. Separation was effected on a RP-C18 column, using a mixture of acetonitrile-water-triethylamine (70/30/0.5, v/v). ITX was rapidly cleared from human plasma and metabolites appeared as early as 7.5 min p.i. Quantitative assessment of metabolites in plasma over time allowed recalculation of the ITX plasma time-activity curve. Implications of ITX metabolite formation for breast tumour imaging are discussed.</description><subject>123I</subject><subject>Aged</subject><subject>Anticarcinogenic Agents - blood</subject><subject>Anticarcinogenic Agents - metabolism</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Contrast media. Radiopharmaceuticals</subject><subject>Endocrine glands. Genital system. Mammary gland</subject><subject>Female</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Iodine Radioisotopes - blood</subject><subject>Iodine Radioisotopes - metabolism</subject><subject>Iodine Radioisotopes - pharmacokinetics</subject><subject>Medical sciences</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Radionuclide investigations</subject><subject>Tamoxifen</subject><subject>Tamoxifen - analogs & derivatives</subject><subject>Tamoxifen - blood</subject><subject>Tamoxifen - metabolism</subject><subject>Tamoxifen - pharmacokinetics</subject><issn>0969-8051</issn><issn>1872-9614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFrFTEQx4Mo9rX6EZSAIHpYTbLZ7OYkUqwtFDyo55BNJn2RZLNNsqLf3jzfox6Fgbn85j_DbxB6Qck7Sqh4_5VIIbuJDPQNoW8JoXLoyCO0o9PIOikof4x2D8gZOi_lR4MEp-QpOqO0Zz3jYofCtb_b4xWySznqxQAO_n7zFpt9TlHXdJf1uvcGW6iQo1909WnByWHK-u4GBz1DAIurjumXd7DgCFXPKfgKBfsF77cWi9egS9TP0BOnQ4Hnp36Bvl99-nZ53d1--Xxz-fG2M3wYamelGYmh4ziwCcBSmA0ZJ8do32ttpDVCjzMTM9eSjdYR53rOJ-6EGDidZtNfoNfH3DWn-w1KVdEXAyHoBdJW1Egm0kywBg5H0ORUSgan1uyjzr8VJeqgWf3VrA4OFWl10KxIm3t5WrDNEey_qZPXBrw6AboYHVxuan154KQcpl426sORgibjp4esivHQnmB9BlOVTf4_h_wBw_qaaQ</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>De Vos, Filip</creator><creator>Van de Wielea, Christophe</creator><creator>Vandecapelle, Marleen</creator><creator>Dierckx, Rudi Andre</creator><creator>Slegers, Guido</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010401</creationdate><title>High performance liquid chromatographic determination of 123-I labeled tamoxifen metabolites in human plasma</title><author>De Vos, Filip ; Van de Wielea, Christophe ; Vandecapelle, Marleen ; Dierckx, Rudi Andre ; Slegers, Guido</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-d9c70c177528eed1ebc078f2133aac9dc6a7b26b4a927df0ff34484f665418bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>123I</topic><topic>Aged</topic><topic>Anticarcinogenic Agents - blood</topic><topic>Anticarcinogenic Agents - metabolism</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Contrast media. 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123I]Iodomethyl-N,N-diethyltamoxifen (ITX), a radioligand for human breast cancer imaging, in human plasma is described. Separation was effected on a RP-C18 column, using a mixture of acetonitrile-water-triethylamine (70/30/0.5, v/v). ITX was rapidly cleared from human plasma and metabolites appeared as early as 7.5 min p.i. Quantitative assessment of metabolites in plasma over time allowed recalculation of the ITX plasma time-activity curve. Implications of ITX metabolite formation for breast tumour imaging are discussed.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>11323246</pmid><doi>10.1016/S0969-8051(01)00195-0</doi><tpages>4</tpages></addata></record> |
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| ispartof | Nuclear medicine and biology, 2001-04, Vol.28 (3), p.335-338 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 123I Aged Anticarcinogenic Agents - blood Anticarcinogenic Agents - metabolism Biological and medical sciences Chromatography, High Pressure Liquid Contrast media. Radiopharmaceuticals Endocrine glands. Genital system. Mammary gland Female Humans Injections, Intravenous Investigative techniques, diagnostic techniques (general aspects) Iodine Radioisotopes - blood Iodine Radioisotopes - metabolism Iodine Radioisotopes - pharmacokinetics Medical sciences Metabolites Middle Aged Pharmacology. Drug treatments Radionuclide investigations Tamoxifen Tamoxifen - analogs & derivatives Tamoxifen - blood Tamoxifen - metabolism Tamoxifen - pharmacokinetics |
| title | High performance liquid chromatographic determination of 123-I labeled tamoxifen metabolites in human plasma |
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