Squamous Cell Carcinoma of the Vulva Stage IA: Long-Term Results

Objective. The aim of this study was to evaluate the risk of metastases to lymph nodes and long-term results of radical and modified radical surgery in patients with a T1 squamous cell carcinoma of the vulva and ≤1 mm of invasion. Methods. A retrospective review of 40 patients with T1 squamous cell...

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Veröffentlicht in:Gynecologic oncology 2000-01, Vol.76 (1), p.24-27
Hauptverfasser: Magrina, Javier F., Gonzalez-Bosquet, Jesus, Weaver, Amy L., Gaffey, Thomas A., Leslie, Kevin O., Webb, Maurice J., Podratz, Karl C.
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container_end_page 27
container_issue 1
container_start_page 24
container_title Gynecologic oncology
container_volume 76
creator Magrina, Javier F.
Gonzalez-Bosquet, Jesus
Weaver, Amy L.
Gaffey, Thomas A.
Leslie, Kevin O.
Webb, Maurice J.
Podratz, Karl C.
description Objective. The aim of this study was to evaluate the risk of metastases to lymph nodes and long-term results of radical and modified radical surgery in patients with a T1 squamous cell carcinoma of the vulva and ≤1 mm of invasion. Methods. A retrospective review of 40 patients with T1 squamous cell carcinoma of the vulva and ≤1 mm of invasion was performed. The clinical, pathologic, surgical, and follow-up data were abstracted from the patients' records. All slides were reviewed by two pathologists according to previously established guidelines. The overall mean follow-up was 7.6 years. Results. Vulvar recurrence developed in 2 patients (5-year rate, 5.9%). There were no groin recurrences among 10 patients undergoing groin lymphadenectomy. One of the 30 patients (10-year rate, 6.7%) without groin dissection developed groin metastases at 7.5 years, subsequent to an invasive vulvar recurrence. The 5- and 10-year cause-specific survivals were 100 and 94.7%, respectively. Conclusion. T1 squamous cell carcinoma of the vulva with ≤1 mm of invasion was associated with a low risk of vulvar recurrence and no groin node metastases. A low risk of subsequent groin node metastasis exists in patients developing an invasive vulvar recurrence. Long-term follow-up of these patients is recommended. Lesser forms of vulvar excision, such as wide local excision, were equally effective as radical vulvectomy for the prevention of vulvar recurrences. Patients treated by radical vulvar surgery experienced increased postoperative complications compared with patients treated by less radical surgery.
doi_str_mv 10.1006/gyno.1999.5638
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The aim of this study was to evaluate the risk of metastases to lymph nodes and long-term results of radical and modified radical surgery in patients with a T1 squamous cell carcinoma of the vulva and ≤1 mm of invasion. Methods. A retrospective review of 40 patients with T1 squamous cell carcinoma of the vulva and ≤1 mm of invasion was performed. The clinical, pathologic, surgical, and follow-up data were abstracted from the patients' records. All slides were reviewed by two pathologists according to previously established guidelines. The overall mean follow-up was 7.6 years. Results. Vulvar recurrence developed in 2 patients (5-year rate, 5.9%). There were no groin recurrences among 10 patients undergoing groin lymphadenectomy. One of the 30 patients (10-year rate, 6.7%) without groin dissection developed groin metastases at 7.5 years, subsequent to an invasive vulvar recurrence. The 5- and 10-year cause-specific survivals were 100 and 94.7%, respectively. Conclusion. T1 squamous cell carcinoma of the vulva with ≤1 mm of invasion was associated with a low risk of vulvar recurrence and no groin node metastases. A low risk of subsequent groin node metastasis exists in patients developing an invasive vulvar recurrence. Long-term follow-up of these patients is recommended. Lesser forms of vulvar excision, such as wide local excision, were equally effective as radical vulvectomy for the prevention of vulvar recurrences. Patients treated by radical vulvar surgery experienced increased postoperative complications compared with patients treated by less radical surgery.</description><identifier>ISSN: 0090-8258</identifier><identifier>EISSN: 1095-6859</identifier><identifier>DOI: 10.1006/gyno.1999.5638</identifier><identifier>PMID: 10620436</identifier><identifier>CODEN: GYNOA3</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - secondary ; Carcinoma, Squamous Cell - surgery ; Female ; Follow-Up Studies ; Humans ; Lymph Node Excision ; Lymphatic Metastasis ; Medical sciences ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Neoplasm Recurrence, Local ; Postoperative Complications ; Prognosis ; Retrospective Studies ; Risk Factors ; squamous cancer ; stage IA ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the genital tract and mammary gland ; vulvar carcinoma ; Vulvar Neoplasms - pathology ; Vulvar Neoplasms - surgery</subject><ispartof>Gynecologic oncology, 2000-01, Vol.76 (1), p.24-27</ispartof><rights>2000 Academic Press</rights><rights>2000 INIST-CNRS</rights><rights>Copyright 2000 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-f80c0b49c7956e6db8565c0922460d57c6364438b065b837fe7a9021e043499a3</citedby><cites>FETCH-LOGICAL-c369t-f80c0b49c7956e6db8565c0922460d57c6364438b065b837fe7a9021e043499a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/gyno.1999.5638$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=1241398$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10620436$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Magrina, Javier F.</creatorcontrib><creatorcontrib>Gonzalez-Bosquet, Jesus</creatorcontrib><creatorcontrib>Weaver, Amy L.</creatorcontrib><creatorcontrib>Gaffey, Thomas A.</creatorcontrib><creatorcontrib>Leslie, Kevin O.</creatorcontrib><creatorcontrib>Webb, Maurice J.</creatorcontrib><creatorcontrib>Podratz, Karl C.</creatorcontrib><title>Squamous Cell Carcinoma of the Vulva Stage IA: Long-Term Results</title><title>Gynecologic oncology</title><addtitle>Gynecol Oncol</addtitle><description>Objective. The aim of this study was to evaluate the risk of metastases to lymph nodes and long-term results of radical and modified radical surgery in patients with a T1 squamous cell carcinoma of the vulva and ≤1 mm of invasion. Methods. A retrospective review of 40 patients with T1 squamous cell carcinoma of the vulva and ≤1 mm of invasion was performed. The clinical, pathologic, surgical, and follow-up data were abstracted from the patients' records. All slides were reviewed by two pathologists according to previously established guidelines. The overall mean follow-up was 7.6 years. Results. Vulvar recurrence developed in 2 patients (5-year rate, 5.9%). There were no groin recurrences among 10 patients undergoing groin lymphadenectomy. One of the 30 patients (10-year rate, 6.7%) without groin dissection developed groin metastases at 7.5 years, subsequent to an invasive vulvar recurrence. The 5- and 10-year cause-specific survivals were 100 and 94.7%, respectively. Conclusion. T1 squamous cell carcinoma of the vulva with ≤1 mm of invasion was associated with a low risk of vulvar recurrence and no groin node metastases. A low risk of subsequent groin node metastasis exists in patients developing an invasive vulvar recurrence. Long-term follow-up of these patients is recommended. Lesser forms of vulvar excision, such as wide local excision, were equally effective as radical vulvectomy for the prevention of vulvar recurrences. Patients treated by radical vulvar surgery experienced increased postoperative complications compared with patients treated by less radical surgery.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Lymph Node Excision</subject><subject>Lymphatic Metastasis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Recurrence, Local</subject><subject>Postoperative Complications</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>squamous cancer</subject><subject>stage IA</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the genital tract and mammary gland</subject><subject>vulvar carcinoma</subject><subject>Vulvar Neoplasms - pathology</subject><subject>Vulvar Neoplasms - surgery</subject><issn>0090-8258</issn><issn>1095-6859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLxDAURoMozvjYupQsxF3Hm6ZJE1fK4GNgQPC1DWl6O1b6mElawX9vywzoxlU2Jx_nHkLOGMwYgLxafTftjGmtZ0JytUemDLSIpBJ6n0wBNEQqFmpCjkL4BAAOLD4kEwYyhoTLKbl52fS2bvtA51hVdG69K5u2trQtaPeB9L2vvix96ewK6eL2mi7bZhW9oq_pM4a-6sIJOShsFfB09x6Tt_u71_ljtHx6WMxvl5HjUndRocBBlmiXaiFR5pkSUjjQcZxIyEXqJJdJwlUGUmSKpwWmVkPMcNBMtLb8mFxud9e-3fQYOlOXwQ3OtsFB36SgQAynDuBsCzrfhuCxMGtf1tZ_GwZmbGbGZmZsZsZmw4fz3XKf1Zj_wbeRBuBiB9jgbFV427gy_HJxwrged9QWwyHDV4neBFdi4zAvPbrO5G35n8IPakyE-g</recordid><startdate>200001</startdate><enddate>200001</enddate><creator>Magrina, Javier F.</creator><creator>Gonzalez-Bosquet, Jesus</creator><creator>Weaver, Amy L.</creator><creator>Gaffey, Thomas A.</creator><creator>Leslie, Kevin O.</creator><creator>Webb, Maurice J.</creator><creator>Podratz, Karl C.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200001</creationdate><title>Squamous Cell Carcinoma of the Vulva Stage IA: Long-Term Results</title><author>Magrina, Javier F. ; Gonzalez-Bosquet, Jesus ; Weaver, Amy L. ; Gaffey, Thomas A. ; Leslie, Kevin O. ; Webb, Maurice J. ; Podratz, Karl C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-f80c0b49c7956e6db8565c0922460d57c6364438b065b837fe7a9021e043499a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Lymph Node Excision</topic><topic>Lymphatic Metastasis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Recurrence, Local</topic><topic>Postoperative Complications</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>squamous cancer</topic><topic>stage IA</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the genital tract and mammary gland</topic><topic>vulvar carcinoma</topic><topic>Vulvar Neoplasms - pathology</topic><topic>Vulvar Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Magrina, Javier F.</creatorcontrib><creatorcontrib>Gonzalez-Bosquet, Jesus</creatorcontrib><creatorcontrib>Weaver, Amy L.</creatorcontrib><creatorcontrib>Gaffey, Thomas A.</creatorcontrib><creatorcontrib>Leslie, Kevin O.</creatorcontrib><creatorcontrib>Webb, Maurice J.</creatorcontrib><creatorcontrib>Podratz, Karl C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Magrina, Javier F.</au><au>Gonzalez-Bosquet, Jesus</au><au>Weaver, Amy L.</au><au>Gaffey, Thomas A.</au><au>Leslie, Kevin O.</au><au>Webb, Maurice J.</au><au>Podratz, Karl C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Squamous Cell Carcinoma of the Vulva Stage IA: Long-Term Results</atitle><jtitle>Gynecologic oncology</jtitle><addtitle>Gynecol Oncol</addtitle><date>2000-01</date><risdate>2000</risdate><volume>76</volume><issue>1</issue><spage>24</spage><epage>27</epage><pages>24-27</pages><issn>0090-8258</issn><eissn>1095-6859</eissn><coden>GYNOA3</coden><abstract>Objective. The aim of this study was to evaluate the risk of metastases to lymph nodes and long-term results of radical and modified radical surgery in patients with a T1 squamous cell carcinoma of the vulva and ≤1 mm of invasion. Methods. A retrospective review of 40 patients with T1 squamous cell carcinoma of the vulva and ≤1 mm of invasion was performed. The clinical, pathologic, surgical, and follow-up data were abstracted from the patients' records. All slides were reviewed by two pathologists according to previously established guidelines. The overall mean follow-up was 7.6 years. Results. Vulvar recurrence developed in 2 patients (5-year rate, 5.9%). There were no groin recurrences among 10 patients undergoing groin lymphadenectomy. One of the 30 patients (10-year rate, 6.7%) without groin dissection developed groin metastases at 7.5 years, subsequent to an invasive vulvar recurrence. The 5- and 10-year cause-specific survivals were 100 and 94.7%, respectively. Conclusion. T1 squamous cell carcinoma of the vulva with ≤1 mm of invasion was associated with a low risk of vulvar recurrence and no groin node metastases. A low risk of subsequent groin node metastasis exists in patients developing an invasive vulvar recurrence. Long-term follow-up of these patients is recommended. Lesser forms of vulvar excision, such as wide local excision, were equally effective as radical vulvectomy for the prevention of vulvar recurrences. Patients treated by radical vulvar surgery experienced increased postoperative complications compared with patients treated by less radical surgery.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>10620436</pmid><doi>10.1006/gyno.1999.5638</doi><tpages>4</tpages></addata></record>
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subjects Adult
Aged
Aged, 80 and over
Biological and medical sciences
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - secondary
Carcinoma, Squamous Cell - surgery
Female
Follow-Up Studies
Humans
Lymph Node Excision
Lymphatic Metastasis
Medical sciences
Middle Aged
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasm Recurrence, Local
Postoperative Complications
Prognosis
Retrospective Studies
Risk Factors
squamous cancer
stage IA
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the genital tract and mammary gland
vulvar carcinoma
Vulvar Neoplasms - pathology
Vulvar Neoplasms - surgery
title Squamous Cell Carcinoma of the Vulva Stage IA: Long-Term Results
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