Frequency‐domain photon migration measurements for quantitative assessment of powder absorbance: A novel sensor of blend homogeneity
The measurement and analysis of frequency‐domain photon migration (FDPM) measurements of powder absorbance in pharmaceutical powders is described in the context of other optical techniques. FDPM consists of launching intensity‐modulated light into a powder and detecting the phase delay and amplitude...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1999-10, Vol.88 (10), p.959-966 |
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| container_end_page | 966 |
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| container_title | Journal of pharmaceutical sciences |
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| creator | Shinde, Rajesh R. Balgi, G.V. Nail, S.L. Sevick-Muraca, E.M. |
| description | The measurement and analysis of frequency‐domain photon migration (FDPM) measurements of powder absorbance in pharmaceutical powders is described in the context of other optical techniques. FDPM consists of launching intensity‐modulated light into a powder and detecting the phase delay and amplitude modulation of the re‐emitted light as a function of the modulation frequency. From analysis of the data using the diffusion approximation to the radiative transport equation, the absorption coefficient can be obtained. Absorption coefficient measurements of riboflavin in lactose mixtures are presented at concentrations of 0.1 to 1% (w/w) at near‐infrared wavelengths where solution absorption cross sections are difficult to accurately measure using traditional transmission measurements in nonscattering solutions. FDPM measurements in powders enabled determinations of absorption coefficients that increase linearly with concentration (w/w) according to Beer–Lambert relationship. The extension of FDPM for monitoring absorbance of low‐dose and ultralow‐dose powder blending operations is presented. |
| doi_str_mv | 10.1021/js990079+ |
| format | Article |
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FDPM consists of launching intensity‐modulated light into a powder and detecting the phase delay and amplitude modulation of the re‐emitted light as a function of the modulation frequency. From analysis of the data using the diffusion approximation to the radiative transport equation, the absorption coefficient can be obtained. Absorption coefficient measurements of riboflavin in lactose mixtures are presented at concentrations of 0.1 to 1% (w/w) at near‐infrared wavelengths where solution absorption cross sections are difficult to accurately measure using traditional transmission measurements in nonscattering solutions. FDPM measurements in powders enabled determinations of absorption coefficients that increase linearly with concentration (w/w) according to Beer–Lambert relationship. The extension of FDPM for monitoring absorbance of low‐dose and ultralow‐dose powder blending operations is presented.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1021/js990079+</identifier><identifier>PMID: 10514339</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>New York: Elsevier Inc</publisher><subject>Absorption ; Algorithms ; Analysis ; Biological and medical sciences ; Chemistry, Pharmaceutical - instrumentation ; Diffusion ; Drug Compounding ; General pharmacology ; Lactose - chemistry ; Medical sciences ; Pharmacology. Drug treatments ; Photons ; Powders ; Riboflavin - administration & dosage ; Riboflavin - chemistry ; Spectrophotometry, Ultraviolet</subject><ispartof>Journal of pharmaceutical sciences, 1999-10, Vol.88 (10), p.959-966</ispartof><rights>1999 Wiley-Liss, Inc. and the American Pharmaceutical Association</rights><rights>Copyright © 1999 Wiley‐Liss, Inc. and the American Pharmaceutical Association</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4243-650fcc2db19db6c6eff6e0269037049389cd75f9ecce0e64144fec608cb6a87b3</citedby><cites>FETCH-LOGICAL-c4243-650fcc2db19db6c6eff6e0269037049389cd75f9ecce0e64144fec608cb6a87b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1021%2Fjs990079%2B$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1021%2Fjs990079%2B$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1976004$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10514339$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shinde, Rajesh R.</creatorcontrib><creatorcontrib>Balgi, G.V.</creatorcontrib><creatorcontrib>Nail, S.L.</creatorcontrib><creatorcontrib>Sevick-Muraca, E.M.</creatorcontrib><title>Frequency‐domain photon migration measurements for quantitative assessment of powder absorbance: A novel sensor of blend homogeneity</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>The measurement and analysis of frequency‐domain photon migration (FDPM) measurements of powder absorbance in pharmaceutical powders is described in the context of other optical techniques. FDPM consists of launching intensity‐modulated light into a powder and detecting the phase delay and amplitude modulation of the re‐emitted light as a function of the modulation frequency. From analysis of the data using the diffusion approximation to the radiative transport equation, the absorption coefficient can be obtained. Absorption coefficient measurements of riboflavin in lactose mixtures are presented at concentrations of 0.1 to 1% (w/w) at near‐infrared wavelengths where solution absorption cross sections are difficult to accurately measure using traditional transmission measurements in nonscattering solutions. FDPM measurements in powders enabled determinations of absorption coefficients that increase linearly with concentration (w/w) according to Beer–Lambert relationship. The extension of FDPM for monitoring absorbance of low‐dose and ultralow‐dose powder blending operations is presented.</description><subject>Absorption</subject><subject>Algorithms</subject><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>Chemistry, Pharmaceutical - instrumentation</subject><subject>Diffusion</subject><subject>Drug Compounding</subject><subject>General pharmacology</subject><subject>Lactose - chemistry</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Photons</subject><subject>Powders</subject><subject>Riboflavin - administration & dosage</subject><subject>Riboflavin - chemistry</subject><subject>Spectrophotometry, Ultraviolet</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10Utv1DAQB_AIgehSOPAFkA8IoaLA5GFnza1ateXRQlFBHC3HmbRuE3vrSbbsjRNnPiOfBK-yPCTEyZbnp7Hn7yR5mMHzDPLsxSVJCVDJZ7eSWcZzSAVk1e1kBpDnacFLuZPcI7oEAAGc3012MuBZWRRylnw7DHg9ojPrH1-_N77X1rHlhR-8Y709D3qwmx1qGgP26AZirQ_setRusEOsrpBpIiTaFJlv2dLfNBiYrsmHWjuDL9k-c36FHSN08XCD6g5dwy5878_RoR3W95M7re4IH2zX3eTT4cHHxav0-P3R68X-cWrKvCxSwaE1Jm_qTDa1MALbViDkQkJRQSmLuTRNxVuJxiCgKLOybNEImJta6HlVF7vJk6nvMvg4Ng2qt2Sw67RDP5KqYA4l50WETydogicK2KplsL0Oa5WB2oSufoUe6aNtz7HusfkLTiFH8HgLNBndtSHGYumPk5UAKCPbm9iN7XD93_vUm9OzzfvSCVsa8MtvrMOVElVRcfX53ZE6WZxx_uHkrTqNPp88xnRXFoMiY-O3Y2MDmkE13v472U-pV7tN</recordid><startdate>199910</startdate><enddate>199910</enddate><creator>Shinde, Rajesh R.</creator><creator>Balgi, G.V.</creator><creator>Nail, S.L.</creator><creator>Sevick-Muraca, E.M.</creator><general>Elsevier Inc</general><general>John Wiley & Sons, Inc</general><general>Wiley</general><general>American Pharmaceutical Association</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199910</creationdate><title>Frequency‐domain photon migration measurements for quantitative assessment of powder absorbance: A novel sensor of blend homogeneity</title><author>Shinde, Rajesh R. ; Balgi, G.V. ; Nail, S.L. ; Sevick-Muraca, E.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4243-650fcc2db19db6c6eff6e0269037049389cd75f9ecce0e64144fec608cb6a87b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Absorption</topic><topic>Algorithms</topic><topic>Analysis</topic><topic>Biological and medical sciences</topic><topic>Chemistry, Pharmaceutical - instrumentation</topic><topic>Diffusion</topic><topic>Drug Compounding</topic><topic>General pharmacology</topic><topic>Lactose - chemistry</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Photons</topic><topic>Powders</topic><topic>Riboflavin - administration & dosage</topic><topic>Riboflavin - chemistry</topic><topic>Spectrophotometry, Ultraviolet</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shinde, Rajesh R.</creatorcontrib><creatorcontrib>Balgi, G.V.</creatorcontrib><creatorcontrib>Nail, S.L.</creatorcontrib><creatorcontrib>Sevick-Muraca, E.M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shinde, Rajesh R.</au><au>Balgi, G.V.</au><au>Nail, S.L.</au><au>Sevick-Muraca, E.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frequency‐domain photon migration measurements for quantitative assessment of powder absorbance: A novel sensor of blend homogeneity</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1999-10</date><risdate>1999</risdate><volume>88</volume><issue>10</issue><spage>959</spage><epage>966</epage><pages>959-966</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>The measurement and analysis of frequency‐domain photon migration (FDPM) measurements of powder absorbance in pharmaceutical powders is described in the context of other optical techniques. FDPM consists of launching intensity‐modulated light into a powder and detecting the phase delay and amplitude modulation of the re‐emitted light as a function of the modulation frequency. From analysis of the data using the diffusion approximation to the radiative transport equation, the absorption coefficient can be obtained. Absorption coefficient measurements of riboflavin in lactose mixtures are presented at concentrations of 0.1 to 1% (w/w) at near‐infrared wavelengths where solution absorption cross sections are difficult to accurately measure using traditional transmission measurements in nonscattering solutions. FDPM measurements in powders enabled determinations of absorption coefficients that increase linearly with concentration (w/w) according to Beer–Lambert relationship. The extension of FDPM for monitoring absorbance of low‐dose and ultralow‐dose powder blending operations is presented.</abstract><cop>New York</cop><pub>Elsevier Inc</pub><pmid>10514339</pmid><doi>10.1021/js990079+</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1999-10, Vol.88 (10), p.959-966 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Absorption Algorithms Analysis Biological and medical sciences Chemistry, Pharmaceutical - instrumentation Diffusion Drug Compounding General pharmacology Lactose - chemistry Medical sciences Pharmacology. Drug treatments Photons Powders Riboflavin - administration & dosage Riboflavin - chemistry Spectrophotometry, Ultraviolet |
| title | Frequency‐domain photon migration measurements for quantitative assessment of powder absorbance: A novel sensor of blend homogeneity |
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