Functional corticospinal projections are established prenatally in the human foetus permitting involvement in the development of spinal motor centres

From studies of subhuman primates it has been assumed that functional corticospinal innervation occurs post-natally in man. We report a post-mortem morphological study of human spinal cord, and neurophysiological and behavioural studies in preterm and term neonates and infants. From morphological st...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2000-01, Vol.123 (1), p.51-64
Hauptverfasser:	Eyre, J. A., Miller, S., Clowry, G. J., Conway, E. A., Watts, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADM = abductor digiti minimi Autopsy biceps = biceps brachii Biological and medical sciences Cerebral Cortex - anatomy & histology Cerebral Cortex - embryology Cerebral Cortex - physiology CMCD = central motor conduction delay corticospinal tract CV = conduction velocity development Development. Senescence. Regeneration. Transplantation Electromyography Embryonic and Fetal Development EPSP = excitatory post-synaptic potential Fetus - anatomy & histology Fundamental and applied biological sciences. Psychology GAP-43 Protein - analysis GAP43 = growth associated protein 43 Gestational Age Group Ia inhibitory interneuron human Humans Infant, Newborn Infant, Premature Interneurons - physiology Motor Neurons - physiology Muscle, Skeletal - innervation Neural Conduction NMDA = N-methyl-d-aspartate PCA = post-conceptional age PMCD = peripheral motor conduction delay PVL = periventricular leucomalacia spinal cord Spinal Cord - anatomy & histology Spinal Cord - embryology Spinal Cord - physiology stretch reflex = homonymous phasic stretch reflex Synapses - physiology Synaptic Transmission TMCD = total motor conduction delay TMS = transcranial magnetic stimulation triceps = triceps brachii Vertebrates: nervous system and sense organs α-motor neuron
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