Use of Soluble Peptide-DR4 Tetramers to Detect Synovial T Cells Specific for Cartilage Antigens in Patients with Rheumatoid Arthritis

Considerable evidence indicates that CD4+T cells are important in the pathogenesis of rheumatoid arthritis (RA), but the antigens recognized by these T cells in the joints of patients remain unclear. Previous studies have suggested that type II collagen (CII) and human cartilage gp39 (HCgp39) are am...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-01, Vol.97 (1), p.291-296
Hauptverfasser:	Kotzin, Brian L., Falta, Michael T., Crawford, Frances, Rosloniec, Edward F., Bill, Jerry, Marrack, Philippa, Kappler, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alleles Animals Antigens Antigens, CD - immunology Arthritis Arthritis, Rheumatoid - immunology Biological Sciences Cartilage Cartilage - immunology CD4-Positive T-Lymphocytes - immunology Collagen - immunology Epitopes Female Flow Cytometry Fluorescent Antibody Technique Fluorescent Dyes histocompatibility antigen HLA HLA-DR4 Antigen - immunology Humans Hybridomas Hybridomas - immunology Immunology Joint diseases Male Mice Mice, Transgenic Middle Aged Molecules Peptide Fragments - immunology Peptides Synovial fluid Synovial Fluid - cytology Synovial Fluid - immunology T cell antigen receptors T lymphocytes T-Lymphocytes - immunology
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