Inhibition of T-cell invasion across cultured fibroblast monolayers by phenothiazine-related calmodulin inhibitors: impairment of lymphocyte motility by trifluoperazine and chlorpromazine, and alteration of the monolayer by pimozide

Phenothiazines inhibit the typical shape changes displayed by activated lymphocytes and thereby their migration through polycarbonate filters. The structure activity relationship of this effect is distinct from calmodulin inhibition. Our aim was to study this effect of phenothiazines on lymphocyte m...

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Veröffentlicht in:	Biochemical pharmacology 2001-05, Vol.61 (10), p.1313-1317
Hauptverfasser:	Grabski, Robert, Dewit, Joelle, De Braekeleer, Jos, Malicka-Blaskiewicz, Maria, De Baetselier, Patrick, Verschuerena, Hendrik
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calmodulin Calmodulin - antagonists & inhibitors Calmodulin - metabolism Cell Movement - drug effects Cell physiology Cells, Cultured Chlorpromazine Chlorpromazine - pharmacology Dopamine Antagonists - pharmacology Fundamental and applied biological sciences. Psychology Haloperidol - pharmacology Humans Medical sciences Mice Migration Molecular and cellular biology Motility and taxis Neuropharmacology Pharmacology. Drug treatments Pimozide Pimozide - pharmacology Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Sulfonamides - pharmacology T-cell T-Lymphocytes - drug effects T-Lymphocytes - physiology Trifluoperazine Trifluoperazine - pharmacology Tumor Cells, Cultured Vasodilator Agents - pharmacology
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