No evidence of association between the D10S1423 locus and Alzheimer disease in Brazilian patients

In a genome survey for Alzheimer's disease (AD), Zubenko et al. (1998) reported that the 234bp allele of the D10S1423 locus was more frequent among AD cases than in controls. We have analyzed this polymorphic locus in patients and healthy controls and observed that the 226bp allele is the most...

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Veröffentlicht in:	Journal of Neural Transmission 2001-01, Vol.108 (3), p.305-310
Hauptverfasser:	Nishimura, A L, Oliveira, J R, Otto, P A, Matioli, S R, Brito-Marques, P R, Bahia, V S, Nitrini, R, Zatz, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - epidemiology Alzheimer Disease - genetics Alzheimer Disease - metabolism Brazil - epidemiology Chromosomes, Human, Pair 10 - genetics DNA Mutational Analysis Female Gene Frequency - genetics Genetic Markers - genetics Genetic Testing Humans Male Middle Aged Mutation - genetics Polymorphism, Genetic - genetics Sex Factors
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Zusammenfassung:	In a genome survey for Alzheimer's disease (AD), Zubenko et al. (1998) reported that the 234bp allele of the D10S1423 locus was more frequent among AD cases than in controls. We have analyzed this polymorphic locus in patients and healthy controls and observed that the 226bp allele is the most frequent allele in the D10S1423 locus in Brazilian AD patients. However, no statistically significant association between any D10S1423 allele was observed in AD patients as well as in controls.
ISSN:	0300-9564 1435-1463
DOI:	10.1007/s007020170076